The Effect of Sex on the Remimazolam Dosage Required for Successful i-gel Supraglottic Airway Insertion with Remifentanil in Non-Paralyzed Patients: An Up-and-Down Sequential Allocation Trial.

The physiological and pharmacological variations between men and women are known to influence drug efficacy. The objective of this study was to determine the 50% and 95% effective doses (ED and ED) of remimazolam required for i-gel supraglottic airway (ISA) insertion under remifentanil infusion without neuromuscular blocking agents (NMBAs) in both males and females. Patients aged 19-65 years, scheduled for general anesthesia using ISA, were enrolled in this study.

Preventive effect of aripiprazole once-monthly on relapse into mood episodes in bipolar disorder: A multicenter, one-year, retrospective, mirror image study.

Background: We conducted a one-year, retrospective, mirror-image study to investigate the clinical effectiveness and safety of aripiprazole once monthly (AOM) in patients with bipolar disorder (BD). We compared pre-treatment conditions with outcomes after 12 months of AOM treatment.

Methods: Seventy-five bipolar patients were recruited from 12 hospitals in Korea.

Optimizing Optical Dielectrophoretic (ODEP) Performance: Position- and Size-Dependent Droplet Manipulation in an Open-Chamber Oil Medium.

An optimization study is presented to enhance optical dielectrophoretic (ODEP) performance for effective manipulation of an oil-immersed droplet in the floating electrode optoelectronic tweezers (FEOET) device. This study focuses on understanding how the droplet's position and size, relative to light illumination, affect the maximum ODEP force. Numerical simulations identified the characteristic length () of the electric field as a pivotal factor, representing the location of peak field strength.

Anti-Staphylococcal Activity of SWLA-1 and Its Supernatant against Multidrug-Resistant in Novel Rat Model of Acute Osteomyelitis.

Osteomyelitis caused by staphylococcal infection is a serious complication of orthopedic surgery. is the main causative agent of osteomyelitis in veterinary medicine. Methicillin-resistant (MRSP) has been reported in companion animals, especially dogs.

An arrayed optofluidic system for three-dimensional (3D) focal control via electrowetting.

A new lens capability for three-dimensional (3D) focal control is presented using an optofluidic system consisting of n × n arrayed liquid prisms. Each prism module contains two immiscible liquids in a rectangular cuvette. Using the electrowetting effect, the shape of the fluidic interface can be rapidly adjusted to create its straight profile with the prism's apex angle.

Psychometric Properties of the Korean Version of Functioning Assessment Short Test in Bipolar Disorder.

Objective: The Functioning Assessment Short Test (FAST) is a relatively specific test for bipolar disorders designed to assess the main functioning problems experienced by patients. This brief instrument includes 24 items assessing impairment or disability in 6 domains of functioning: autonomy, occupational functioning, cognitive functioning, financial issues, interpersonal relationships, and leisure time. It has already been translated into standardized versions in several languages.

Korean Medication Algorithm Project for Bipolar Disorder 2022: Comparisons with Other Treatment Guidelines.

The objective of this study was to compare recommendations of the Korean Medication Algorithm Project for Bipolar Disorder 2022 (KMAP-BP 2022) with other recently published guidelines for treating bipolar disorder. We reviewed a total of six recently published global treatment guidelines and compared treatment recommendation of the KMAP-BP 2022 with those of other guidelines. For initial treatment of mania, there were no significant differences across treatment guidelines.

Korean Medication Algorithm Project for Bipolar Disorder 2022, Fifth Revision: An Executive Summary.

Objective: We revised the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP), first published in 2002 and revised in 2006, 2010, 2014, and 2018, to reflect recent progress in the treatment of bipolar disorder.

Methods: The questionnaires consisted of 56 items for adult patients and 7 items for child/adolescent patients, and were used to obtain the consensus of experts regarding pharmacological treatment strategies for various phases of bipolar disorder. The review committee included 87 Korean psychiatrists and 40 child and adolescent psychiatry experts.

A review of optoelectrowetting (OEW): from fundamentals to lab-on-a-smartphone (LOS) applications to environmental sensors.

Electrowetting-on-dielectric (EWOD) has been extensively explored as an active-type technology for small-scale liquid handling due to its several unique advantages, including no requirement of mechanical components, low power consumption, and rapid response time. However, conventional EWOD devices are often accompanied with complex fabrication processes for patterning and wiring of 2D arrayed electrodes. Furthermore, their sandwich device configuration makes integration with other microfluidic components difficult.

Amisulpride Augmentation in Schizophrenia Patients with Poor Response to Olanzapine: A 4-week, Randomized, Rater-Blind, Controlled, Pilot Study.

Objective: The purpose of this study was to compare the efficacy and tolerability of continued olanzapine (OLA) versus amisulpride (AMI) augmentation in schizophrenic patients with poor response to OLA monotherapy.

Methods: The present 4-week, randomized, rater-blinded study included 25 patients with schizophrenia who were partially or completely unresponsive to treatment with OLA monotherapy. Eligible subjects were randomly assigned at a 1:1 ratio to continuation of OLA monotherapy (OLA group) or OLA with AMI augmentation (AMI group).

Different outcomes of multiple sialadenitis involving the submandibular and zygomatic salivary glands in a Welsh Corgi dog.

A ten-year-old indoor, castrated male Cardigan Welsh Corgi () presented with the chief complaints of chronic vomiting, retching, hypersalivation, and bilateral submandibular masses for two months. The systemic examinations, including serum chemistry, radiography, ultrasonography, and fluoroscopy, were unremarkable. A fine-needle aspiration revealed bilateral submandibular sialadenitis.

Optical Dielectrophoretic (DEP) Manipulation of Oil-Immersed Aqueous Droplets on a Plasmonic-Enhanced Photoconductive Surface.

We present a plasmonic-enhanced dielectrophoretic (DEP) phenomenon to improve optical DEP performance of a floating electrode optoelectronic tweezers (FEOET) device, where aqueous droplets can be effectively manipulated on a light-patterned photoconductive surface immersed in an oil medium. To offer device simplicity and cost-effectiveness, recent studies have utilized a polymer-based photoconductive material such as titanium oxide phthalocyanine (TiOPc). However, the TiOPc has much poorer photoconductivity than that of semiconductors like amorphous silicon (a-Si), significantly limiting optical DEP applications.

Capacitance Effects of a Hydrophobic-Coated Ion Gel Dielectric on AC Electrowetting.

We present experimental studies of alternating current (AC) electrowetting dominantly influenced by several unique characteristics of an ion gel dielectric in its capacitance. At a high-frequency region above 1 kHz, the droplet undergoes the contact angle modification. Due to its high-capacitance characteristic, the ion gel allows the contact angle change as large as Δ = 26.

Vibration motor-integrated low-cost, miniaturized system for rapid quantification of red blood cell aggregation.

Human red blood cells (RBCs) aggregate under low shear conditions, which significantly modulates flow resistance and tissue perfusion. A higher aggregation tendency in blood thus serves as an important clinical indicator for the screening of cardiovascular disorders. Conventional ways of measuring RBC aggregation still require large sample volumes, cumbersome manual procedures, and expensive benchtop systems.

Pathologic mallet fracture of distal phalanx enchondroma: A case report.

Introduction: Enchondromas arise from cartilaginous cells derived from the physis that persists throughout development. They are difficult to diagnose and are often discovered on radiographs after a trauma.

Patient Concerns: We discuss the case of a 32-year-old woman with a pathologic mallet fracture of the distal phalanx that was initially misdiagnosed as common mallet fracture.

A Distributed Oracle Using Intel SGX for Blockchain-Based IoT Applications.

A is a problem that defines a mechanism for how to safely bring external data to the blockchain. Although there have been various research efforts to solve this problem, existing solutions are limited in that they do not support either data availability or data integrity. Furthermore, no solution has been proposed to minimize the response time when an oracle server is malicious or overloaded.

A Cloud-based Middleware for Self-Adaptive IoT-Collaboration Services.

The middleware framework for IoT collaboration services should provide efficient solutions to context awareness and uncertainty issues among multiple collaboration domains. However, existing middleware frameworks are mostly limited to a single system, and developing self-adaptive IoT collaboration services using existing frameworks requires developers to take considerable time and effort. Furthermore, the developed IoT collaboration services are often dependent on a particular domain, which cannot easily be referenced in other domains.

An automated 3D-printed smartphone platform integrated with optoelectrowetting (OEW) microfluidic chip for on-site monitoring of viable algae in water.

A sudden increase of algae and their associated toxins in aquatic ecosystems can detrimentally affect the quality of the water, causing serious socio-economic and public health problems. To prevent the spread of harmful algae in aquatic ecosystems, it is essential to track the water's quality through rapid and in-situ monitoring systems. Conventional methods of algae quantification such as microscopy, hemocytometry, and UV-vis spectroscopy, however, are often unsuitable or inconvenient for in-situ assessment as they require skilled labor and expensive equipment.

Structural Safety Evaluation of Precast, Prestressed Concrete Deck Slabs Cast Using 120-MPa High-Performance Concrete with a Reinforced Joint.

Prestressed concrete structures are used in various fields as they can reduce the cross-sectional area of members compared with reinforced concrete structures. In addition, the use of high-performance and strength concrete can help reduce weight and achieve excellent durability. Recently, structures have increasingly been constructed using high-performance and strength concrete, and therefore, structural verification is required.

Rapid and in-situ detection of fecal indicator bacteria in water using simple DNA extraction and portable loop-mediated isothermal amplification (LAMP) PCR methods.

Contamination of water by fecal matter and potential human enteric pathogens is a serious health concern. Microbiological water quality has been assessed by conventional culture-based methods of fecal indicator bacteria (FIB). Recently, molecular techniques for FIB have been introduced as alternative tools for rapid detection.

The prevalence and diagnostic classification of mixed features in patients with major depressive episodes: A multicenter study based on the DSM-5.

Objectives: The purpose of this study was to evaluate the prevalence of mixed features using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and to examine how patients with mixed states would be classified using the DSM-5.

Methods: In total, 12 hospitals participated in this study, and data on the demographic characteristics and clinical diagnoses of patients treated between October 2013 and September 2016 were obtained. We reviewed the data for opposite-polarity symptoms according to the DSM-5 criteria and the research-based diagnostic criteria.

An Automatic User Activity Analysis Method for Discovering Latent Requirements: Usability Issue Detection on Mobile Applications.

Starting with the Internet of Things (IoT), new forms of system operation concepts have emerged to provide creative services through collaborations among autonomic devices. Following these paradigmatic changes, the ability of each participating system to automatically diagnose the degree of quality it is providing is inevitable. This paper proposed a method to automatically detect symptoms that hinder certain quality attributes.