Publications by authors named "Sungryeong Lee"
Tissue barriers in a body, well known as tissue-to-tissue interfaces represented by endothelium of the blood vessels or epithelium of organs, are essential for maintaining physiological homeostasis by regulating molecular and cellular transports. It is crucial for predicting drug response to understand physiology of tissue barriers through which drugs are absorbed, distributed, metabolized and excreted. Since the FDA Modernization Act 2.
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- Regulation of cell junctions is vital for maintaining epithelial tissue integrity and organ growth, with TCTP being a key protein in growth control whose role in cell junctions was previously unclear.
- Research highlights that Drosophila Tctp interacts with the septate junction protein Coracle (Cora), which is crucial for proper epithelial structure and organ development.
- Double mutations in Cora and Tctp lead to severe developmental issues, including lethal disruptions in embryos and abnormal growth patterns in eye and wing structures, indicating their essential roles in regulating epithelial integrity and preventing overgrowth.