Publications by authors named "Sungnoh Hong"
Article Synopsis
- Thiopurines are used to treat steroid-refractory and steroid-dependent ulcerative colitis, but their early use's effectiveness is debated.
- A study divided patients into those starting thiopurine therapy within 6 months of diagnosis and those who started later to assess relapse rates.
- Results showed no significant difference in clinical relapse rates between early and late thiopurine therapy, although extraintestinal manifestations increased relapse risk.
Little is known about the ability for epithelial regeneration and wound healing in patients with inflammatory bowel diseases. We evaluated the epithelial proliferation and wound healing ability of patients with Crohn's disease (CD) using patient-derived intestinal organoids. Human intestinal organoids were constructed in a three-dimensional intestinal crypt culture of enteroscopic biopsy samples from controls and CD patients.
View Article and Find Full Text PDFIL-33 (IL-1F11) is a member of IL-1 family ligand, which stimulates the production of inflammatory cytokines. IL-33 receptor complex is comprised of IL-1 receptor accessory protein (IL-1RAcP) and ST2 that are activated by IL-33 ligand binding. ST2 is a ligand-binding chain of the IL-33 receptor component, and the soluble ST2 form possesses antagonistic activity.
View Article and Find Full Text PDFIncidence and Multiplicities of Adenomatous Polyps in TNM Stage I Colorectal Cancer in Korea.
J Korean Soc Coloproctol
August 2012
Purpose: In recent years, the incidence of early-stage colorectal cancer (CRC) has markedly increased in the population within the Republic of Korea. The aim of this study was to evaluate the clinicopathologic features of adenomatous polyps in TNM stage I CRC patients and in the general population.
Methods: Between March 2003 and September 2009, 168 patients with stage I CRC were enrolled in this study.