Predictive ability of the pooled cohort risk assessment for the incidence and progression of coronary artery calcification.

Objective: The aim of the present study was to evaluate the predictive ability of pooled cohort risk assessment (PRA) models for the incidence and progression of coronary artery calcification (CAC) over time comparing the Framingham risk score (FRS) in a healthy Korean population.

Methods: The study cohort included 4194 individuals, aged 40 or older, without a history of cardiovascular disease or statin therapy, who underwent repeated cardiac computed tomography for CAC scoring from 2011 to 2014. Logistic regression models and Cox proportional hazards models were used.

Estimation of risk for diabetes according to the metabolically healthy status stratified by degree of obesity in Korean men.

Although obesity is clearly identified as a risk factor for diabetes, the relationship between diabetes and metabolically healthy status of obesity is less clear. This study was aimed to evaluate the incidental risk of diabetes according to metabolically healthy status of obesity. 31,834 Korean men without diabetes categorized into six groups according to their metabolically healthy status stratified by degree of obesity were followed up for 5 years: metabolically healthy normal weight (MH-NW), metabolically healthy overweight (MH-OW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MU-NW), metabolically unhealthy overweight (MU-OW), and metabolically unhealthy obese (MUO).

Intraocular pressure and coronary artery calcification in asymptomatic men and women.

Objective: We evaluated the relationship between intraocular pressure (IOP) and the risk of coronary artery calcification as a predictable marker of cardiovascular disease (CVD) in a large study of asymptomatic men and women.

Methods: A cross-sectional study was performed in 10 732 asymptomatic men and women without diagnosed CVD or glaucoma. Coronary artery calcium (CAC) was measured by cardiac CT.

Use of selective serotonin reuptake inhibitors and risk of fracture: a systematic review and meta-analysis.

Previous studies have reported inconsistent findings regarding the association between the use of selective serotonin reuptake inhibitors (SSRIs) and the risk of fracture. We identified relevant studies by searching three electronic databases (MEDLINE, EMBASE, and the Cochrane Library) from their inception to October 20, 2010. Two evaluators independently extracted data.