Publications by authors named "Sunghyeok Ye"
Mutations in specific genes, including synuclein alpha () that encodes the α-synuclein protein, are known to be risk factors for sporadic Parkinson's disease (PD), as well as critical factors for familial PD. In particular, A53T-mutated (A53T-SNCA) is a well-studied familial pathologic mutation in PD. However, techniques for deletion of the mutated gene have not been developed.
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- Ligamentum flavum hypertrophy (LFH) plays a key role in causing lumbar spinal canal stenosis, but effective prevention or treatment methods have yet to be established.
- The study focused on the TGF-β pathway, which is significant in LFH, utilizing CRISPR technology to create TGFBR1 knockout cells to explore blocking this pathway’s effects.
- Results showed that CCN5 treatment reduced fibrosis-related mRNA expression and diminished the transition of LF cells to myofibroblasts when exposed to TGF-β1, suggesting CCN5 may help prevent LFH by modulating the TGF-β pathway.
Purpose: Majority of the previous studies compared lumbar spinal stenosis (LSS) and lumbar disc herniation (LDH) patients for analyses of LFH. However, the separation of normal/hypertrophied LF has often been ambiguous and the severity of hypertrophic activity differed. Here, we present a novel analysis scheme for LFH in which myofibroblast is proposed as a major etiological factor for LFH study.
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