Publications by authors named "Sunghan Shim"
Article Synopsis
- The study investigated the genetic differences between fetuses with fetal growth restriction (FGR) and normal growth using amniotic fluid samples to isolate cell-free fetal RNA for analysis.
- A total of 411 genes were found to be differentially expressed, with 316 genes up-regulated (linked to metabolic processes) and 95 down-regulated (associated with brain function and receptor activity).
- Notably, genes like LRP10 and IGF-2 showed significant increases in FGR cases, indicating crucial changes in brain-related gene expression during the second trimester and highlighting the need for further research on these genes' roles in fetal development.
Previous reports on the analysis of the human monoblastic cell line U937 had described several sublines containing unidentified rearrangements and marker chromosomes. In order to determine the true nature of the rearrangements, conventional banding analysis was carried out with various combinations of molecular cytogenetic techniques: comparative genomic hybridization, fluorescence in situ hybridization (FISH) with whole chromosome painting probes, and microdissection and reverse painting FISH. The origins of the marker chromosomes were identified and the composite karyotype is described.
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