Efficient and Inexpensive Synthesis of N-Labeled 2-Azido-1,3-dimethylimidazolinium Salts Using NaNO Instead of NaNNN.

N-Labeled azides are important probes for infrared and magnetic resonance spectroscopy and imaging. They can be synthesized by reaction of primary amines with a N-labeled diazo-transfer reagent. We present the synthesis of N-labeled 2-azido-1,3-dimethylimidazolinium salts as a N-labeled diazo-transfer reagent.

Investigation of d-Amino Acid-Based Surfactants and Nanocomposites with Gold and Silica Nanoparticles as against Multidrug-Resistant Bacteria Agents.

d-amino acid-based surfactants (d-AASs) were synthesized and their antimicrobial activity was evaluated. -α-lauroyl-d-arginine ethyl ester hydrochloride (d-LAE), d-proline dodecyl ester (d-PD), and d-alanine dodecyl ester (d-AD) were found to have antibacterial activity against both Gram-positive and -negative bacteria, but less efficacy against Gram-negative bacteria. For these reasons, combining antimicrobial agents with nanoparticles is a promising technique for improving their antibacterial properties to eliminate drug-resistant pathogens.

TfNNN: A γ-N-Labeled Diazo-Transfer Reagent for the Synthesis of β-N-Labeled Azides.

Azides are infrared (IR) probes that are important for structure and dynamics studies of proteins. However, they often display complex IR spectra owing to Fermi resonances and multiple conformers. Isotopic substitution of azides weakens the Fermi resonance, allowing more accurate IR spectral analysis.