Bundle structures inside the deep cervical lymphatic vessels of mice.

The lymphatic system plays a crucial role in immune function and the removal of cellular waste. Recent studies have highlighted the presence of primo vessels (PVs) inside lymphatic vessels, distinct from conventional lymphatic tissues, yet their structural and functional characteristics remain poorly understood, particularly PVs inside deep cervical lymphatic vessels (dcLVs) connected to the meningeal lymphatics. We used a combination of Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), Alcian Blue (AB) and H&E staining techniques to identify and characterize PVs inside the dcLVs of mice.

Analysis of key pathways and genes in nodal structure on rat skin surface using gene ontology and KEGG pathway.

Background: We have previously reported anatomical, histological, and gene expression characteristics of the nodal structure of rat skin surface and suggested its potential as an acupuncture point. However, the specific characteristics of the interactions among the genes expressed in this structure remain unclear.

Objective: We aimed to determine gene expression changes by analyzing interaction networks of genes up-regulated in nodal structures and to explore relationships with acupuncture points.

Antidepressant-like Effects of L. Extract in an Lipopolysaccharide Model: Modulation of Mast Cell Activation in Deep Cervical Lymph Nodes and Dura Mater.

Background: Lipopolysaccharide (LPS)-induced neuroinflammation is a well-established model for studying depression-like behavior, driven by pro-inflammatory cytokines such as TNF-α and IL-1β. Mast cells (MCs) contribute to neuroinflammation by releasing mediators that exacerbate depressive-like symptoms. This study evaluates the antidepressant-like and anti-inflammatory effects of L.

Sustained Area-Selectivity in Atomic Layer Deposition of Ir Films: Utilization of Dual Effects of O in Deposition and Etching.

Area-selective deposition (ASD) based on self-aligned technology has emerged as a promising solution for resolving misalignment issues during ultrafine patterning processes. Despite its potential, the problems of area-selectivity losing beyond a certain thickness remain critical in ASD applications. This study reports a novel approach to sustain the area-selectivity of Ir films as the thickness increases.

Single stranded 1D-helical Cu coordination polymer for ultra-sensitive ammonia sensing at room temperature.

With the increasing demand for ammonia applications, there is a significant focus on improving NH detection performance at room temperature. In this study, we introduce a groundbreaking NH gas sensor based on Cu(I)-based coordination polymers, featuring semiconducting, single stranded 1D-helical nanowires constructed from Cu-Cl and -methylthiourea (MTCP). The MTCP demonstrates an exceptional response to NH gas (>900% at 100 ppm) and superior selectivity at room temperature compared to current materials.

In Vitro and In Vivo Anti-Inflammatory and Antidepressant-like Effects of L. Extracts.

L. has been widely used by humans for centuries for various purposes, such as industrial, ceremonial, medicinal, and food. The bioactive components of L.

Unlocking the Potential of Porous BiTe-Based Thermoelectrics Using Precise Interface Engineering through Atomic Layer Deposition.

Porous thermoelectric materials offer exciting prospects for improving the thermoelectric performance by significantly reducing the thermal conductivity. Nevertheless, porous structures are affected by issues, including restricted enhancements in performance attributed to decreased electronic conductivity and degraded mechanical strength. This study introduces an innovative strategy for overcoming these challenges using porous BiSbTe (BST) by combining porous structuring and interface engineering via atomic layer deposition (ALD).

Characteristics of the New Mast Cell-Rich Nodal Structure in the Rat Skin Surface.

Background: : Acupuncture, practiced for millennia, lacks a clear anatomical definition for acupoints. A prevailing theory suggests that acupoints overlap with skin areas with higher mast cell density. Skin spots stained with intravenously infused Evans blue (EB), indicative of neurogenic inflammation, have recently been posited as acupoints in rats.

Difference of Microbial Community in the Stream Adjacent to the Mixed Antibiotic Effluent Source.

Released antibiotics from source to stream can influence bacterial communities and potentially alter the ecosystem. This research provides a comprehensive examination of the sources, distribution, and bacterial community dynamics associated with varied antibiotic release sources adjacent to the stream. The residual of antibiotics from different sources was determined, and the bacterial community structure was examined to reveal the differences in the bacteria community in the stream.

Harnessing CRISPR-Cas adaptation for RNA recording and beyond.

Prokaryotes encode clustered regularly interspaced short palindromic repeat (CRISPR) arrays and CRISPR-associated (Cas) genes as an adaptive immune machinery. CRISPR-Cas systems effectively protect hosts from the invasion of foreign enemies, such as bacteriophages and plasmids. During a process called 'adaptation', non-self-nucleic acid fragments are acquired as spacers between repeats in the host CRISPR array, to establish immunological memory.

LncRNA-miRNA-mRNA regulatory networks in skin aging and therapeutic potentials.

Skin aging is a complex process influenced by intrinsic and extrinsic factors. Although dermatology offers advanced interventions, molecular mechanisms in skin aging remain limited. Competing endogenous RNAs (ceRNAs), a subset of coding or non-coding RNAs, regulate gene expression through miRNA competition.

Primo Vessels Inside Lymphatic Vessels Are Absent in an ALS Mouse Model.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective death of motor neurons in the central nervous system. It is also a representative rare disease among degenerative diseases of the nervous system. Although many drugs for the treatment of degenerative brain diseases are being developed, they are not delivered correctly to the target due to the blood-brain barrier.

Tissue Concentration Analysis of Sulfur, Calcium and Oxygen in Novel Skin Primo Nodes After Acupuncture.

Over the past 5000 years, acupuncture has been practiced in Korea, China, and Japan to relieve various diseases, and it is now widely used and accepted worldwide. Although the anatomical substance and function of meridians has been actively studied, it is still not clearly defined. One of the keys to acupuncture is determining the specific anatomical location exactly on or under the skin.

Nucleation and Layer Closure Behavior of Iridium Films Grown Using Atomic Layer Deposition.

Understanding the initial growth process during atomic layer deposition (ALD) is essential for various applications employing ultrathin films. This study investigated the initial growth of ALD Ir films using tricarbonyl-(1,2,3-η)-1,2,3-tri(-butyl)-cyclopropenyl-iridium and O. Isolated Ir nanoparticles were formed on the oxide surfaces during the initial growth stage, and their density and size were significantly influenced by the growth temperature and substrate surface, which strongly affected the precursor adsorption and surface diffusion of the adatoms.

Evaluation of the Effects of Differences in Metal Artifact Type and Location on Image Quality in Computed Tomography Scans.

Artifacts in computed tomography scans distort anatomical information and prevent an accurate diagnosis. Therefore, this study aims to determine the most effective method for reducing metal-induced artifacts by evaluating the effects of the metal artifact type and location, and the tube voltage on the image quality. Fe and Cu wires were inserted into a Virtual Water™ phantom at 6.

Efficacy of mecasin for treatment of amyotrophic lateral sclerosis: A phase IIa multicenter randomized double-blinded placebo-controlled trial.

Ethnopharmacological Relevance: Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder characterized by progressive paralysis of voluntary muscles. Mecasin, the extract of modified jakyakgamchobuja-tang-a herbal preparation comprising of Radix Paeoniae Alba, Radix Glycyrrhizae, Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae, Rhizoma Gastrodiae, Radix Polygalae, Curcuma Root, Fructus Chaenomelis, and Rhizoma Atractylodis Japonicae-shows neuroprotective and anti-neuroinflammatory effects and alleviates the symptoms in patients with ALS.

Aim Of The Study: This trial aimed to evaluate the efficacy and safety of mecasin in these patients.

Crystallization-based upcycling of iron oxyhydroxide for efficient arsenic capture in contaminated soils.

Arsenic (As)-contaminated soil inevitably exists in nature and has become a global challenge for a sustainable future. Current processes for As capture using natural and structurally engineered nanomaterials are neither scientifically nor economically viable. Here, we established a feasible strategy to enhance As-capture efficiency and ecosystem health by structurally reorganizing iron oxyhydroxide, a natural As stabilizer.

ABSORBED DOSE AND IMAGE QUALITY ACCORDING TO THE SCAN MODE AND SHIELD POSITION IN PEDIATRIC BRAIN COMPUTED TOMOGRAPHY SCANS.

In this study, computed tomography dose index (CTDIvol), dose-length product (DLP), organ dose and signal-to-noise ratio (SNR) were measured in pediatric brain helical and volumetric CT scans using a pediatric phantom (equivalent to a 10-year-old) and optically stimulated luminescence dosemeters (OSLD) as the scan protocol used in Hospital A. Volumetric scans showed lower CTDIvol, DLP and organ dose than helical scans, and the SNR showed similar results. The organ doses were lower in the phantoms protected with front, rear or front and rear shielding than in those without shielding.

Differential microRNA profiles in elderly males with seborrheic dermatitis.

Seborrheic dermatitis (SD) is one of the most common skin diseases characterized by inflammatory symptoms and cell proliferation, which has increased incidence in patients older than 50 years. Although the roles of microRNAs (miRNAs) have been investigated in several diseases, miRNA profiles of patients with SD remain unknown. This study aimed to identify differentially expressed miRNAs (DEMs) in lesions of elderly male patients with SD.

Control of Healthcare-Associated Infections using Silver Nanoparticles in Radiology.

Aims: The control of healthcare-associated infections (HCAIs) is a significant concern in the field of radiology due to multiple contact-transmitted pathogens on imaging devices. The antimicrobial effects of silver nanoparticles (AgNPs) in preventing HCAIs and their effects on imaging quality were evaluated.

Methods: The antimicrobial effects of AgNPs were tested on prevalent contact-transmitted pathogens present in radiology examination rooms, including methicillin-resistant (MRSA), vancomycin-resistant Enterococci (VRE), , and .

Diagnostic Assessment of Deep Learning Algorithms for Frozen Tissue Section Analysis in Women with Breast Cancer.

Purpose: Assessing the metastasis status of the sentinel lymph nodes (SLNs) for hematoxylin and eosin-stained frozen tissue sections by pathologists is an essential but tedious and time-consuming task that contributes to accurate breast cancer staging. This study aimed to review a challenge competition (HeLP 2019) for the development of automated solutions for classifying the metastasis status of breast cancer patients.

Materials And Methods: A total of 524 digital slides were obtained from frozen SLN sections: 297 (56.

Bioaccumulation and Mass Balance Analysis of Veterinary Antibiotics in an Agricultural Environment.

Veterinary antibiotics (VAs) released into the environment are a concern because of the possibility for increasing antibiotic-resistance genes. The concentrations of six VAs, chlortetracycline, oxytetracycline, tetracycline, sulfamethazine, sulfamethoxazole, and sulfathiazole, in manure-based compost, soil, and crops were measured using liquid chromatography-tandem mass spectrometry. Mass balance analysis was conducted based on the measured antibiotic concentration, cultivation area, and amount of manure-based compost applied.

Analysis of Major Bacteria and Diversity of Surface Soil to Discover Biomarkers Related to Soil Health.

The discovery of biomarkers for assessing soil health requires the exploration of organisms that can explain the core functions of soil and identification of species with major roles in these functions. However, identifying specific keystone markers within the soil microbiota is challenging. Next-generation sequencing (NGS)-based molecular-biological methods have revealed information on soil biodiversity; however, whether this biodiversity is related to soil health remains unclear.