Simultaneous measurements of temporal evolutions of the voltage and the current on the load of the Seoul National University X-pinch device using the optics-based systems.

Optics-based measurement systems have been developed to measure the voltage and the current on a load of the Seoul National University X-pinch device [Ryu et al., Rev. Sci.

A Survey on Satellite Communication System Security.

In recent years, satellite communication systems (SCSs) have rapidly developed in terms of their role and capabilities, promoted by advancements in space launch technologies. However, this rapid development has also led to the emergence of significant security vulnerabilities, demonstrated through real-world targeted attacks such as AcidRain and AcidPour that demand immediate attention from the security community. In response, various countermeasures, encompassing both technological and policy-based approaches, have been proposed to mitigate these threats.

Acute kidney injury due to intravenous detergent poisoning: A case report.

Background: Detergent poisoning mostly occurs through oral ingestion (> 85%), ocular exposure (< 15%), or dermal exposure (< 8%). Reports of detergent poisoning through an intravenous injection are extremely rare. In addition, there are very few cases of renal toxicity directly caused by detergents.

Matrix Metalloproteinase-1 (MMP1) Upregulation through Promoter Hypomethylation Enhances Tamoxifen Resistance in Breast Cancer.

Background: Tamoxifen (tam) is widely used to treat estrogen-positive breast cancer. However, cancer recurrence after chemotherapy remains a major obstacle to achieve good patient prognoses. In this study, we aimed to identify genes responsible for epigenetic regulation of tam resistance in breast cancer.

Advanced PLGA hybrid scaffold with a bioactive PDRN/BMP2 nanocomplex for angiogenesis and bone regeneration using human fetal MSCs.

Biodegradable polymers have been used with various systems for tissue engineering. Among them, poly(lactic-co-glycolic) acid (PLGA) has been widely used as a biomaterial for bone regeneration because of its great biocompatibility and biodegradability properties. However, there remain substantial cruxes that the by-products of PLGA result in an acidic environment at the implanting site, and the polymer has a weak mechanical property.

A modular X-pinch device for versatile X-pinch experiments at Seoul National University.

This paper describes an X-pinch device recently developed at Seoul National University (SNU). The SNU X-pinch device is designed and fabricated to accommodate various diagnostics as well as conduct versatile experiments. It is easy to change the capacitance of the pulse generator because the capacitor bank has a modular design without insulation oil or gas.

Development of a filtered AXUV diode array for X-pinch soft x-ray spectra in the energy range of 1-10 keV.

We develop a filtered absolute extreme ultraviolet (AXUV) diode array to measure the time evolution of the soft x-ray spectrum in the energy range of 1-10 keV. AXUV-HS5, the detector, has a fast rise time of 0.7 ns, a wide energy detection range, and high accessibility.

Optimized Thermoelectric Performance of Carbon Nanoparticle-Carbon Nanotube Heterostructures by Tuning Interface Barrier Energy.

Herein, thermoelectric carbon nanoparticle (CNP)-carbon nanotube (CNT) heterostructures are introduced as a promising flexible thermoelectric material. The optimal barrier energy between the CNP and CNT increases the Seebeck coefficient () of the heterostructures through the energy filtering effect. For optimized thermoelectric performance, the CNP-CNT barrier energy can be effectively tuned by controlling the work function of the CNPs.

Scaffold-supported extracellular matrices preserved by magnesium hydroxide nanoparticles for renal tissue regeneration.

Fibroblast-derived extracellular matrix (fECM)-supported scaffolds made up of poly(lactic-co-glycolic acid) were prepared with the enhanced preservation of ECM components by composites with magnesium hydroxide nanoparticles (MH NPs), and were applied for the renal tissue regeneration. MH NP utilization resulted in an increased ECM protein amount, decreased scaffold degradation, and surface hydrophilic modification. These effects were correlated with the improved adhesion and viability of renal proximal tubule epithelial cells on the scaffold.

Shape-Deformable Thermoelectric Carbon Nanotube Doughs.

In this study, shape-deformable thermoelectric p- and n-type doughs are fabricated by blending single-walled carbon nanotubes with excess amounts of nonvolatile liquid surfactants for efficient energy harvesting from diverse heat sources. The shape-deformable thermoelectric doughs exhibit touch-healing properties and can be easily molded into arbitrary shapes by simple shaping methods, such as those commonly used for rubber play dough. We used cube-shaped thermoelectric doughs to fabricate a vertical thermoelectric generator.

Attenuation of Tumor Necrosis Factor-α Induced Inflammation by Umbilical Cord-Mesenchymal Stem Cell Derived Exosome-Mimetic Nanovesicles in Endothelial Cells.

Background: Inflammation induces dysfunction of endothelial cells via inflammatory cell adhesion, and this phenomenon and reactive oxygen species accumulation are pivotal triggers for atherosclerosis-related vascular disease. Although exosomes are excellent candidate as an inhibitor in the inflammation pathway, it is necessary to develop exosome-mimetic nanovesicles (NVs) due to limitations of extremely low release rate and difficult isolation of natural exosomes. NVs are produced in much larger quantities than natural exosomes, but due to the low flexibility of the cell membranes, the high loss caused by hanging on the filter membranes during extrusion remains a challenge to overcome.

Recent trends in cell membrane-cloaked nanoparticles for therapeutic applications.

Synthetic nanoparticles are extensively utilized in various biomedical engineering fields because of their unique physicochemical properties. However, their exogenous characteristics result in synthetic nanosystem invaders that easily induce the passive immune clearance mechanism, thereby increasing the retention effect caused by reticuloendothelial system (RES), resulting in low therapeutic efficacy and toxic effects. Recently, a cell membrane cloaking has been emerging technique as a novel interfacing approach from the biological/immunological perspective.

Cold Atmospheric Plasma Restores Paclitaxel Sensitivity to Paclitaxel-Resistant Breast Cancer Cells by Reversing Expression of Resistance-Related Genes.

Paclitaxel (Tx) is a widely used therapeutic chemical for breast cancer treatment; however, cancer recurrence remains an obstacle for improved prognosis of cancer patients. In this study, cold atmospheric plasma (CAP) was tested for its potential to overcome the drug resistance. After developing Tx-resistant MCF-7 (MCF-7/TxR) breast cancer cells, CAP was applied to the cells, and its effect on the recovery of drug sensitivity was assessed in both cellular and molecular aspects.

Ginsenoside Rg3 and Korean Red Ginseng extract epigenetically regulate the tumor-related long noncoding RNAs RFX3-AS1 and STXBP5-AS1.

Background: Ginsenoside Rg3, a derivative of steroidal saponins abundant in ginseng, has a range of effects on cancer cells, including anti-cell proliferation and anti-inflammation activity. Here, we investigate two long noncoding RNAs (lncRNAs), STXBP5-AS1 and RFX3-AS1, which are hypomethylated and hypermethylated in the promoter region by Rg3 in MCF-7 cancer cells.

Methods: The lncRNAs epigenetically regulated by Rg3 were mined using methylation array analysis.

Ginsenoside Rh2 Suppresses Breast Cancer Cell Proliferation by Epigenetically Regulating the Long Noncoding RNA C3orf67-AS1.

Ginsenoside Rh2, a major bioactive ingredient abundant in red ginseng, has an antiproliferative effect on various cancer cells. In this study, we report a novel long noncoding RNA, C3orf67-AS1, which was identified as being hypermethylated at a CpG site of the promoter by Rh2 in MCF-7 cancer cells. Rh2-induced hypermethylation was responsible for the lower gene expression; the expression was recovered following treatment with a methyltransferase inhibitor, 5-aza-2-deoxycytidine.

A Mesoporous Chelating Polymer-Carbon Composite for the Hyper-Efficient Separation of Heavy Metal Ions.

The removal of heavy-metal ions from wastewater is an important objective from a public-health perspective, and chelating agents can be used to achieve this aim. Herein, we report the synthesis of mesoporous carbon as a chelating polymer host using nanoarchitectonics approach. Carboxymethylated polyethyleneimine, a chelating polymer, was incorporated into the mesopore walls of mesoporous carbon to create a polymer-mesoporous-carbon composite.

Computer-aided discovery of connected metal-organic frameworks.

Composite metal-organic frameworks (MOFs) tend to possess complex interfaces that prevent facile and rational design. Here we present a joint computational/experimental workflow that screens thousands of MOFs and identifies the optimal MOF pairs that can seamlessly connect to one another by taking advantage of the fact that the metal nodes of one MOF can form coordination bonds with the linkers of the second MOF. Six MOF pairs (HKUST-1@MOF-5, HKUST-1@IRMOF-18, UiO-67@HKUST-1, PCN-68@MOF-5, UiO-66@MIL-88B(Fe) and UiO-67@MIL-88C(Fe)) yielded from our theoretical predictions were successfully synthesized, leading to clean single crystalline MOF@MOF, demonstrating the power of our joint workflow.

Phase control of quasi-2D perovskites and improved light-emitting performance by excess organic cations and nanoparticle intercalation.

The optoelectronic properties of quasi-two-dimensional organic-inorganic hybrid perovskites can be tuned by controlling the formation of Ruddlesden-Popper type phases, which enables diverse device applications such as photovoltaics and light-emitting diodes (LEDs). Herein, the influence of excess organic cations on the phase formation of (PEA)2MAn-1PbnBr3n+1 is systematically investigated with various mixing ratios to discover the phase distribution beneficial for light-emitting diodes. It is found that PEA cations exceeding Pb ions in molar ratio are required to produce small-n phases in the films with a strong photoluminescence, while excess MA cations enable the formation of more large-n phases.

A Kelch domain-containing KLHDC7B and a long non-coding RNA ST8SIA6-AS1 act oppositely on breast cancer cell proliferation via the interferon signaling pathway.

In our previous study, the Kelch domain-containing 7B (KLHDC7B) was revealed to be hypermethylated at the promoter but upregulated in breast cancer. In this study, we identified a long non-coding RNA, ST8SIA6-AS1 (STAR1), whose expression was significantly associated with KLHDC7B in breast cancer (R = 0.3466, P < 0.

Genome-Wide Methylation Analysis Identifies NOX4 and KDM5A as Key Regulators in Inhibiting Breast Cancer Cell Proliferation by Ginsenoside Rg3.

Ginsenoside Rg3 is a key metabolite of ginseng and is known to inhibit cancer cell growth. However, the epigenetics of CpG methylation and its regulatory mechanism have yet to be determined. Genome-wide methylation analysis of MCF-7 breast cancer cells treated with Rg3 was performed to identify epigenetically regulated genes and pathways.

ChIP-seq analysis reveals alteration of H3K4 trimethylation occupancy in cancer-related genes by cold atmospheric plasma.

Cold atmospheric plasma (CAP) has gained attention for use in cancer treatment owing to its ability to preferentially induce cancer cell death; however, the involved molecular mechanism remains to be elucidated. Herein, an epigenetic effect of CAP on cancer cells was examined by performing a genome-wide ChIP-seq for H3K4me3 in MCF-7 breast cancer cell line. Consequently, 899 genes showed significantly changed methylation level at H3K4 with constructing "Cellular Compromise, DNA Replication, Recombination, Repair, and Cell Cycle" as the top network.

Intraoperative Vascular Surgical Consultation during Non-Vascular Surgeries in Tertiary Centers by Vascular Surgeon.

Purpose: There are many types of intraoperative consultations by vascular surgeons during non-vascular surgery. Therefore, we examined the current state of intraoperative consultations during non-vascular surgery in a single center.

Materials And Methods: From January 2014 to December 2015, we reviewed records of 40 patients (0.

MicroRNA-7-5p mediates the signaling of hepatocyte growth factor to suppress oncogenes in the MCF-10A mammary epithelial cell.

MicroRNA-7 (miR-7) is a non-coding RNA of 23-nucleotides that has been shown to act as a tumor suppressor in various cancers including breast cancer. Although there have been copious studies on the action mechanisms of miR-7, little is known about how the miR is controlled in the mammary cell. In this study, we performed a genome-wide expression analysis in miR-7-transfected MCF-10A breast cell line to explore the upstream regulators of miR-7.