Publications by authors named "SungGyu Lee"

Background & Aims: The global pandemic caused by the highly contagious SARS-CoV-2 virus led to the emergency approval of COVID-19 vaccines to reduce rising morbidity and mortality. However, limited research exists on evaluating the impact of these vaccines on immunocompromised individuals, such as recipients of living donor liver transplantation, highlighting the need for further studies to better understand their effectiveness in this specific population.

Methods: From June 2021, we followed up on the effectiveness of the vaccine for patients taking immunosuppressive drugs after living-donor liver transplantation (LDLT).

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According to global regulations on hazardous chemicals, numerous alternatives have been manufactured and used in various consumer products. Suspect and non-target analyses are advanced analytical techniques used for identifying novel contaminants. In the present study, suspect and non-target analytical approaches using a gas chromatography coupled to a time-of-flight mass spectrometer were applied to identify novel contaminants in 40 pooled serum samples from a sub-population (n = 400) of the 2015-2017 national biomonitoring program.

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Atopic dermatitis (AD) is a chronic inflammatory skin disorder associated with significant morbidity, including pruritus, recurrent skin lesions, and immune dysregulation. This study aimed to investigate the antioxidative and anti-AD effects of peptides derived from hydrolyzed (Korea rockfish) tail by-products. Hydrolysates were prepared using various enzymes, including Alcalase, Flavourzyme, Neutrase, and Protamex.

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  • This study compares adult living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) outcomes in patients with acute liver failure over a 14-year period.
  • The findings show no significant differences in in-hospital mortality, long-term survival, or graft survival rates between the two methods, although LDLT patients had shorter intensive care unit stays.
  • The research concludes that LDLT is a viable alternative for patients awaiting liver transplants, particularly when deceased donor organs are not accessible.
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Peptides, composed of 2-50 amino acids, have gained attention in anti-aging treatments due to their high safety, low irritation, and cost-effective production. This study aimed to evaluate the anti-wrinkle efficacy of Tetrapeptide-68, derived from the skin structural protein Loricrin, on periorbital wrinkles in women aged 30-65 years. A 12-week, double-blind, randomized controlled trial was conducted with 25 participants who applied the Tetrapeptide-68 (100 ppm) O/W formulation around the eyes.

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  • The skin is susceptible to damage from UV rays and oxidative stress, which can result in aging and pigmentation issues; this study explores the potential of a decapeptide (DP) from marine fish by-products as a skin-whitening agent.
  • DP showed strong antioxidant activity, outperforming Vitamin C in various tests, and demonstrated protective effects on HaCaT cells against hydrogen peroxide damage while also inhibiting melanin production in melanoma cells.
  • The research indicates that DP interacts strongly with tyrosinase, an enzyme involved in melanin production, suggesting it has promising properties for skin whitening and warrants further studies to optimize its effectiveness.
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Background: Contrast-enhanced T1-weighted magnetic resonance cholangiography (CE-T1-MRC) after gadoxetate disodium administration can be used for preoperative evaluation of the bile ducts in live liver donors. This study aimed to determine whether CE-T1-MRC with 3-hour delayed imaging improves bile duct visualization both qualitatively and quantitatively compared with 20-minute delayed imaging in potential living liver donors.

Methods: We retrospectively identified 33 potential living liver donors (mean age, 30.

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Hepatitis B Virus (HBV) infection significantly elevates the risk of hepatocellular carcinoma (HCC), with the HBV X protein (HBx) playing a crucial role in cancer progression. Sorafenib, the primary therapy for advanced HCC, shows limited effectiveness in HBV-infected patients due to HBx-related resistance. Numerous studies have explored combination therapies to overcome this resistance.

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  • This study evaluated the influence of ABO blood types on the recurrence of hepatocellular carcinoma (HCC) in patients who underwent living donor liver transplantation (LDLT).
  • Researchers analyzed 856 patients from 2006 to 2016 and found that the ABO blood group did not significantly affect disease-free survival (DFS) or overall survival (OS) after LDLT.
  • Key factors impacting survival were identified as tumor size and microvascular invasion, while the study concluded that ABO blood type is not a predictive factor for the outcomes in these patients.
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  • Liver transplantation can save lives for people with serious liver problems, but it's important to know who might not survive after the surgery.
  • Researchers studied patients who received liver transplants from living donors between 2010 and 2020 to find out what factors make short-term survival harder.
  • They discovered 4 main risks that can cause death within a year: needing extra support like machines, having more severe liver disease, and having a low weight ratio between the donor and the recipient, which led to a new score system to help doctors evaluate patient risks.
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In this study, we investigated the optical properties of a transition metal dichalcogenide (TMD) substrate via Mie-scattering-induced surface analysis (MISA). Employing near-field optical microscopy and finite-difference time-domain (FDTD) simulations, we systemically prove and directly visualize the Mie scattering of superspherical gold nanoparticles (s-AuNPs) at the nanoscale. Molybdenum disulfide substrates exhibited optical isotropy, while rhenium disulfide (ReS) substrates showed anisotropic behavior attributed to the interaction with incident light's electric field.

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  • Living donor liver transplantation (LDLT) has become a preferred option over deceased donor transplantation, especially in countries like South Korea with low organ donation rates.
  • The Asan Medical Center (AMC) has conducted over 6000 LDLT procedures, developing advanced surgical techniques and achieving high patient survival rates.
  • This large study reveals that tailored surgical approaches and multidisciplinary care significantly enhance the long-term success and safety of LDLT for both adults and children.
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Unlabelled: Human cytochrome P450 2C19 catalyzes P450 enzyme reactions of various substrates, including steroids and clinical drugs. Recombinant P450 2C19 enzyme with histidine tag was successfully expressed in and purified using affinity column chromatography. Ultra-performance liquid chromatography-tandem mass (UPLC-MS/MS) spectrometry showed that the purified P450 2C19 enzyme catalyzed 5-hydroxylation reaction of omeprazole.

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  • A study in South Korea examined the safety and effectiveness of liver transplants from living donors who lost at least 10% of their body weight to reduce liver fat (steatosis) before donating their right lobe.
  • Out of 1,040 donors, 150 were in the weight loss group and showed significant improvements in body weight and BMI, with similar postoperative outcomes and complication rates compared to a control group.
  • The findings suggest that weight loss can effectively enhance liver health in donors, leading to comparable surgical success in both recipients of improved grafts and standard grafts.
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  • Liver transplantation (LT) patients have a higher risk of neurological issues, prompting a study to analyze unruptured intracranial aneurysms (UIAs) and subarachnoid hemorrhage (SAH) occurrences around the LT procedure.
  • The study included 3,487 patients over a ten-year period, finding a 5.4% prevalence of UIAs and low incidences of SAH (0.5%) and hemorrhagic stroke (HS) (1.6%) within a year post-LT.
  • A new scoring system was developed to assess HS risk based on factors like mental status, UIA diagnosis, serum ammonia levels, and MELD scores, demonstrating strong predictive capabilities in identifying at-risk
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  • - This study assessed the impact of low graft-to-recipient weight ratio (GRWR) on the recurrence of hepatocellular carcinoma (HCC) after living donor liver transplantation (LDLT), involving 856 patients at Asan Medical Center from 2006 to 2016.
  • - Results showed no significant differences in disease-free survival (DFS) or overall survival (OS) rates across different GRWR categories, indicating that GRWR does not appear to affect outcomes for HCC patients post-transplant.
  • - The findings suggest that a GRWR of less than 0.8% does not have a significant prognostic effect on oncological results, highlighting the need for further research through high-volume multi-center studies for validation.
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  • Liver transplant recipients are at a heightened risk for tuberculosis (TB), which can lead to increased mortality.
  • A study screened 857 liver transplant candidates for latent tuberculosis infection (LTBI), identifying 199 (23.2%) positive cases, with 171 initiating treatment.
  • Those treated for LTBI had no cases of active TB during follow-up, while untreated individuals had a 3.6% TB development rate, highlighting the effectiveness and safety of LTBI treatment in liver transplant patients.
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  • The COVID-19 pandemic significantly affected global liver transplantation (LT) and living donor programs, prompting the study to examine how these programs adapted and succeeded during this period.
  • The research focused on 1201 living donor liver transplants performed at Asan Medical Center between 2020 and 2022, highlighting key patient demographics and medical outcomes.
  • Despite higher than usual in-hospital mortality at 2.2%, and various challenges, the program maintained high standards of care and successful outcomes thanks to established infection control protocols and tailored surgical strategies.
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  • Hepatic artery thrombosis (HAT) occurs in 2.5%-8% of living-donor liver transplant patients, leading to potential graft loss, and the study focuses on understanding risk factors and reconstruction techniques for grafts with multiple hepatic arteries.
  • The research analyzed 1601 patients who received right lobe grafts, finding that pretransplant hepatectomy, female donor, smaller graft-to-recipient weight ratio, and extra-anatomical reconstruction increased HAT risk, while having two hepatic arteries did not.
  • Survival rates were similar between patients with one and two hepatic arteries, suggesting that reconstructing both arteries when possible might be a beneficial approach in transplant surgeries.
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This study investigated the antioxidant, antimicrobial, and anti-atopic dermatitis (AD) effects of a novel peptide (CP) derived from a by-product hydrolysate. Alcalase, Flavourzyme, Neutrase, and Protamex enzymes were used to hydrolyze the by-product protein, and the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical-scavenging activity was measured. Alcalase hydrolysate exhibited the highest ABTS radical-scavenging activity, leading to the selection of Alcalase for further purification.

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Siloxanes, widely used in various consumer and industrial products, are emerging concerns of contaminants. Despite this, limited studies have been conducted on contamination and time trends on siloxanes in coastal environments. In the present study, four cyclic and 15 linear siloxanes were measured in sediments collected from an artificial saltwater lake in Korea during 2001-2016 to investigate contamination, time trends, and ecotoxicological concerns.

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Siloxanes have been commonly used as additives in a variety of industrial and consumer products. Media and government investigations have revealed that defoamers containing siloxanes are used in the effluent of thermal power plants in Korea. However, investigations of the source impact of siloxane contamination from the discharge of thermal power plants into coastal environments are scarce.

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This study explores the potential of a natural composite formulation known as ED, consisting of ( family: Lessoniaceae) and Linne (, family: Asteraceae), in alleviating lung inflammation induced by fine particulate matter (PM). Initial assessments confirmed that neither ED nor one of its components, dieckol, exhibited cytotoxic effects on A549 cells. Subsequently, the impact of ED and dieckol on gene expression in A549 cells stimulated by phorbol 12-myristate 13-acetate (PMA) was investigated, revealing promising results that demonstrated a dose-dependent inhibition of gene expression.

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Synopsis of recent research by authors named "SungGyu Lee"

  • - Sunggyu Lee's recent research focuses on the development and evaluation of bioactive compounds derived from marine and by-product sources, with particular emphasis on their antioxidative, anti-inflammatory, and skin-enhancing properties, as evidenced by studies on peptides and novel formulations.
  • - A substantial portion of Lee's work also addresses the clinical implications and outcomes of living donor liver transplantation (LDLT), exploring variables such as donor characteristics, surgical techniques, and post-transplant complications, highlighting the importance of innovative practices in this field.
  • - Additionally, Lee investigates environmental contaminants, specifically siloxanes and per- and polyfluoroalkyl substances (PFAS), assessing their presence and impact in various ecological settings, thereby contributing to the understanding of these compounds' effects on health and ecosystems.