Developing a Novel Read-Across Concept for Ecotoxicological Risk Assessment of Phosphate Chemicals: A Case Study.

This study introduces a novel concept approach for a read-across assessment, considering species sensitivity differences among phosphate chemicals within structurally similar compound groups. Twenty-five organic chemicals, with a log Kow of 5 or less, were categorized into three functional groups based on acetylcholinesterase (AChE) inhibition as a specific mode of action (MOA). The short-term aquatic toxicity data (LC) for fish, crustaceans, and insects were collected from the U.

Association of exposure to indoor molds and dampness with allergic diseases at water-damaged dwellings in Korea.

This study aims to characterize levels of molds, bacteria, and environmental pollutants, identify the associations between indoor mold and dampness exposures and childhood allergic diseases, including asthma, allergic rhinitis, atopic dermatitis, using three different exposure assessment tools. A total of 50 children with their parents who registered in Seoul and Gyeonggi-do in Korea participated in this study. We collated the information on demographic and housing characteristics, environmental conditions, and lifestyle factors using the Korean version of the International Study of Asthma and Allergies in Childhood questionnaire.

Real-time counting of wheezing events from lung sounds using deep learning algorithms: Implications for disease prediction and early intervention.

This pioneering study aims to revolutionize self-symptom management and telemedicine-based remote monitoring through the development of a real-time wheeze counting algorithm. Leveraging a novel approach that includes the detailed labeling of one breathing cycle into three types: break, normal, and wheeze, this study not only identifies abnormal sounds within each breath but also captures comprehensive data on their location, duration, and relationships within entire respiratory cycles, including atypical patterns. This innovative strategy is based on a combination of a one-dimensional convolutional neural network (1D-CNN) and a long short-term memory (LSTM) network model, enabling real-time analysis of respiratory sounds.

Spatial modeling for radon concentrations in subway stations in Seoul, Korea.

This study examined the environmental and geological determinants of radon concentration in subway stations by applying a spatial statistical model to the integrated GIS database. The data were collected for 237 underground subway stations located inside the city of Seoul, South Korea and used for mapping to illustrate the spatial distribution of airborne radon exposure and analysis of potential contribution of station-specific and geological determinants. A Bayesian conditional autoregressive regression (CAR) model was developed to explain the radon concentrations, and the predicted radon surface was generated and visualized to identify hotspot regions where elevated radon exposure is likely to be present in underground settings.

Mini-laser based submicron aerosol generator for the simple and stable simulation of combustion particulate matter.

Air pollution causes millions of deaths every year. The aerosols, especially airborne nanoparticles generated by combustion, have detrimental effect on health. To protect public health against harmful aerosols, efforts to develop effective air cleaning technology have continued over the past several decades.

Vital signal sensing and manipulation of a microscale organ with a multifunctional soft gripper.

Soft grippers that incorporate functional materials are important in the development of mechanically compliant and multifunctional interfaces for both sensing and stimulating soft objects and organisms. In particular, the capability for firm and delicate grasping of soft cells and organs without mechanical damage is essential to identify the condition of and monitor meaningful biosignals from objects. Here, we report a millimeter-scale soft gripper based on a shape memory polymer that enables manipulating a heavy object (payload-to-weight ratio up to 6400) and grasping organisms at the micro/milliscale.

Five Year Trends of Particulate Matter Concentrations in Korean Regions (2015-2019): When to Ventilate?

Indoor air quality becomes more critical as people stay indoors longer, particularly children and the elderly who are vulnerable to air pollution. Natural ventilation has been recognized as the most economical and effective means of improving indoor air quality, but its benefit is questionable when the external air quality is unacceptable. Such risk-risk tradeoffs would require evidence-based guidelines for households and policymakers, but there is a lack of research that examines spatiotemporal long-term air quality trends, leaving us unclear on when to ventilate.

Crowdsourced Mapping for Healthy Food Accessibility in Dallas, Texas: A Feasibility Study.

Since its first use for describing a neighborhood lacking access to food in the 1990's, "food deserts" has been widely addressed by researchers and adopted as an indicator of neighborhood-level food insecurity by governmental agencies, such as USDA. However, mostly due to cost and difficulty in collecting georeferenced data and characteristics of grocery stores, the USDA Food Access Research Atlas is infrequently released, and considers only income, vehicle ownership, and distance to the nearest grocery store. In this paper, we explored the feasibility of a crowdsourced geospatial data source, coupled with additional measures, in supplementing the USDA's current designation of food deserts.

Source country-specific burden on health due to high concentrations of PM.

Asian countries face frequent spikes in concentrations of particulate matter smaller than 2.5 μm (PM), which may consist of domestic emissions, transported pollutants from neighboring countries, and secondary aerosol formation (SAF). We aimed to estimate the burden on health in South Korea due to PM exposure from source countries.

FEP Encapsulated Crack-Based Sensor for Measurement in Moisture-Laden Environment.

Among many flexible mechanosensors, a crack-based sensor inspired by a spider's slit organ has received considerable attention due to its great sensitivity compared to previous strain sensors. The sensor's limitation, however, lies on its vulnerability to stress concentration and the metal layers' delamination. To address this issue of vulnerability, we used fluorinated ethylene propylene (FEP) as an encapsulation layer on both sides of the sensor.

A Closer Look at the Bivariate Association between Ambient Air Pollution and Allergic Diseases: The Role of Spatial Analysis.

Although previous ecological studies investigating the association between air pollution and allergic diseases accounted for temporal or seasonal relationships, few studies address spatial non-stationarity or autocorrelation explicitly. Our objective was to examine bivariate correlation between outdoor air pollutants and the prevalence of allergic diseases, highlighting the limitation of a non-spatial correlation measure, and suggesting an alternative to address spatial autocorrelation. The 5-year prevalence data (2011⁻2015) of allergic rhinitis, atopic dermatitis, and asthma were integrated with the measures of four major air pollutants (SO₂, NO₂, CO, and PM) for each of the 423 sub-districts of Seoul.

Association Between Sensitization to Mold and Impaired Pulmonary Function in Children With Asthma.

Purpose: Recent data indicate that sensitization to mold contributes to the severity and persistence of asthma. In this study, we investigated the relationships between sensitization to mold and lung function parameters in children with asthma.

Methods: We retrospectively reviewed clinical data from 551 asthmatic subjects.

Comparison of diverse estimation methods for personal exposure to air pollutants and associations with allergic symptoms: The Allergy & Gene-Environment Link (ANGEL) study.

We estimated the exposure to ambient air pollutants and analyzed the associations with allergic diseases. We enrolled 177 children with atopic dermatitis (AD) and 70 asthmatic adults living in Seoul Metropolitan Area, Korea, and followed for 17months between August 2013 and December 2014. Parents or patients recorded symptom scores on a daily basis.

Leptin and Atopic Dermatitis in Korean Elementary School Children.

The prevalence of atopic dermatitis (AD) and obesity have been increasing considerably in Korean school-children. AD is a chronic pruritic recurrent inflammatory skin disorder. Leptin is secreted by adipocytes which has been suggested to be immunologically active; however, their role in AD has not yet been well understood.

GIS-based Association Between PM10 and Allergic Diseases in Seoul: Implications for Health and Environmental Policy.

Purpose: The role of PM10 in the development of allergic diseases remains controversial among epidemiological studies, partly due to the inability to control for spatial variations in large-scale risk factors. This study aims to investigate spatial correspondence between the level of PM10 and allergic diseases at the sub-district level in Seoul, Korea, in order to evaluate whether the impact of PM10 is observable and spatially varies across the subdistricts.

Methods: PM10 measurements at 25 monitoring stations in the city were interpolated to 424 sub-districts where annual inpatient and outpatient count data for 3 types of allergic diseases (atopic dermatitis, asthma, and allergic rhinitis) were collected.

Submicron fungal fragments as another indoor biocontaminant in elementary schools.

There has been great concern about mold in school environments, but few comprehensive assessments of mold have been performed in such settings. Even spore counts or microscopic enumeration only may not be sufficient for evaluating fungal exposure. We explored the levels of submicron fungal fragments with potential heath impact due to their small size in elementary schools and investigated the variation in the concentrations of such particles before and after the rainy season.

Exploring Household-level Risk Factors for Self-reported Prevalence of Allergic Diseases Among Low-income Households in Seoul, Korea.

Purpose: Indoor risk factors for allergic diseases in low-income households in Korea have been characterized only partially. We evaluated the prevalences of atopic dermatitis, asthma, and allergic rhinitis in Seoul, Korea, to identify key housing and behavioral risk factors of low-income households.

Methods: Statistical analysis of the prevalence of these diseases and various risk factors was conducted using data from a 2010 Ministry of Environment household survey.

Infrared camera-proven water-damaged homes are associated with the severity of atopic dermatitis in children.

Background: Moisture problems in dwellings have been linked to respiratory symptoms, but little is known about their association with symptoms of atopic dermatitis (AD). Moreover, the questionnaire-based survey or visual inspection for water damage does not use a standardized approach for assessing dampness.

Objective: To determine water damage in the houses of children with AD by assessing variations in surface temperature with an infrared camera, an interview-led questionnaire, and evaluation of the relation between the presence of water damage and the severity of AD.

Salmonella typhimurium with γ-radiation induced H2AX phosphorylation and apoptosis in melanoma.

To investigate the combinatorial effects using Salmonella and γ-radiation, the Salmonella typhimurium infection in combination with γ-radiation was investigated on melanoma. We showed that ROS expression and H2AX phosphorylation increased during stress by γ-radiation irrespective of Salmonella infection, inducing apoptosis by caspase-3 and bcl2 in tumor cells. In addition, tumor growth was suppressed by this combinatory therapy suggesting candidates for radiation therapy against melanoma.

Development and evaluation of antimicrobial activated carbon fiber filters using Sophora flavescens nanoparticles.

Activated carbon fiber (ACF) filters have a wide range of applications, including air purification, dehumidification, and water purification, due to their large specific surface area, high adsorption capacity and rate, and specific surface reactivity. However, when airborne microorganisms such as bacteria and fungi adhere to the carbon substrate, ACF filters can become a source of microbial contamination, and their filter efficacy declines. Antimicrobial treatments are a promising means of preventing ACF bio-contamination.

The level of submicron fungal fragments in homes with asthmatic children.

Objectives: Much scientific evidence indicates a positive association between moldy environments and respiratory illnesses and/or symptoms (e.g., asthma).

Asthma and allergic diseases in preschool children in Korea: findings from the pilot study of the Korean Surveillance System for Childhood Asthma.

Objective: This article was intended to introduce the Korean Surveillance System for Childhood Asthma (KSSCA) and also to determine the factors that increase the risk for the development of asthma and allergic diseases in preschool children in Korea based on the study results.

Methods: The KSSCA pilot study was a web-based, cross-sectional survey that sampled 1002 parents with a biological child aged 2-6 years that visited the website and participated in the survey. This website consisted of a questionnaire designed to measure the history and prevalence of asthma and allergic diseases, the characteristics of dwelling, lifestyle, and the socioeconomic status of the subjects.

Antimicrobial durability of air filters coated with airborne Sophora flavescens nanoparticles.

Airborne biological particles containing viruses, bacteria, and/or fungi can be toxic and cause infections and allergy symptoms. Recently, natural materials such as tea tree oil and Sophora flavescens have shown promising antimicrobial activity when applied as air filter media. Although many of these studies demonstrated excellent antimicrobial efficacy, only a few of them considered external environmental effects such as the surrounding humidity, temperature, and natural degradation of chemicals, all of which can affect the antimicrobial performance of these natural materials.

Association of arsenic levels in soil and water with urinary arsenic concentration of residents in the vicinity of closed metal mines.

Arsenic (As) pollution in the surroundings of metal mines has been observed, and may induce serious health problems, in particular cancer. Health hazard attributed to As in contaminated soil and water in the vicinity of closed or abandoned metal mines may be high. Little is known about how environmental exposure to As has affected the health of resident near closed metal mines.