Preparation of tofacitinib sustained-release tablets using hot melt extrusion technology.

This study aimed to develop a tablet that shows a drug release profile similar to the tofacitinib sustained-release tablet (Xeljanz XR®; OROS™) using hot melt extrusion technology. Tofacitinib citrate was selected as the drug. HPMCAS, HPMCP, and Kollidon VA64 were used as thermoplastic polymers to prepare a hot-melt extrudate.

Evaluating the Efficacy of Machine Performance Checks as an Alternative to Winston-Lutz Quality Assurance Testing in the TrueBeam Linear Accelerator with HyperArc.

HyperArc is a preferred technique for treating brain metastases, employing a single isocenter for multiple lesions. Geometrical isocentricity in the TrueBeam linear accelerator with HyperArc is crucial. We evaluated machine performance checks (MPCs) as an alternative to the Winston-Lutz (WL) test to verify the treatment isocenter.

Fabrication of 3D printed head phantom using plaster mixed with polylactic acid powder for patient-specific QA in intensity-modulated radiotherapy.

This study aimed to fabricate a heterogeneous phantom replicating the commercial Rando phantom by mixing plaster powder and polylactic acid (PLA) powder. Producing a heterogeneous phantom using Plaster and PLA is cheaper because it can be easily obtained in the commercial market. Additionally, patient-specific Quality Assurance can be easily performed because the phantom can be produced based on the patient's CT image.

Clinical performance of FractionLab in patient-specific quality assurance for intensity-modulated radiotherapy: a retrospective study.

Backgruound: This study was aimed at comparing and analyzing the results of FractionLab (Varian/Mobius Medical System) with those of portal dosimetry that uses an electronic portal imaging device. Portal dosimetry is extensively used for patient-specific quality assurance (QA) in intensity-modulated radiotherapy (IMRT).

Methods: The study includes 29 patients who underwent IMRT on a Novalis-Tx linear accelerator (Varian Medical System and BrainLAB) between June 2019 and March 2021.

An approach to incorporate multiple forms of iodine in radiological consequence analysis.

Interest is increasing in the radiological consequences of a release of aerosol and gaseous iodine, especially after the Fukushima accident and also because of new interpretations of the results of recent severe accident experiments. This work provides a brief review of the history of iodine chemistry in containment and suggests an approach to include gaseous iodine, namely in the forms of elemental iodine and organic iodide, in consequence analyses using the MACCS code. As dry deposition is an important characteristic to distinguish each chemical form of iodine when performing a consequence analysis, the mechanisms and mathematical formulas expressing dry deposition are also investigated.

Fabrication of electrically conductive nickel-silver bimetallic particles via polydopamine coating.

Inspired by adhesive proteins excreted by marine mussels, dopamine can act as a versatile surface modification agent for various organic and inorganic materials. By using adhesive polydopamine (PDA) as an intermediate layer, a simple and novel method for fabricating nickel-PDA-silver (Ni-PDA-Ag) bimetallic composite particles was developed. Ni-PDA-Ag bimetallic particles were fabricated by dispersing Ni particles in an aqueous dopamine solution followed by electroless Ag plating on the prepared Ni-PDA particles.

Development of an environmental radiation analysis research capability in the UAE.

The UAE has started a nuclear energy program with the aim of having its first four units on-line between 2017 and 2020 and it is important that the country has an environmental radiation analysis capability to support this program. Khalifa University is therefore implementing a research laboratory to support both experimental analysis and radionuclide transport modeling in the aquatic and terrestrial environment. This paper outlines the development of this capability as well as the work in progress and planned for the future.