Publications by authors named "Sung-Sup Shin"
Purpose: The widespread use of nanoparticles (NPs) in industrial and biomedical applications has prompted growing concern regarding their potential toxicity and impact on human health. This study therefore investigated the subchronic, systemic oral toxicity and no-observed-adverse-effect level (NOAEL) of 20 nm, negatively charged zinc oxide (ZnO(SM20(-))) NPs in Sprague Dawley rats for 90 days.
Methods: The high-dose NP level was set at 500 mg/kg of bodyweight, and the mid- and low-dose levels were set at 250 and 125 mg/kg, respectively.
Article Synopsis
- The study aimed to assess the toxicity and establish the no observed adverse effect level (NOAEL) of negatively charged colloidal silica particles in Sprague-Dawley rats, comparing two sizes: 20 nm (SiO2 EN20) and 100 nm (SiO2 EN100).
- Conducted according to OECD guidelines, preliminary tests determined a high dose of 2,000 mg/kg, with middle and low doses set at 1,000 and 500 mg/kg for the 90-day repeated dose study.
- Findings showed no deaths or adverse effects linked to the silica particles, indicating a NOAEL of 2,000 mg/kg for both sizes, with no specific target organ affected in the rats