Inter-segmental motions of the foot in healthy adults: Gender difference.

Background: Multi-segment Foot Models (MFM) have increased in use for both clinical and research applications; however, little is known about the gender differences of inter-segmental motions within the foot and ankle during gait. The objectives of this study were to analyze the gender differences of inter-segmental foot motion during gait in healthy young adults using a MFM with a 15-marker set.

Methods: One hundred healthy adults (50 males, 50 females) between 20 and 35 years of age who had normal function and no radiographic abnormality, were evaluated.

Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin.

Cynomolgus monkeys as nonhuman primates are valuable animal models because they have a high level of human gene homology. There are many reference values for hematology and biochemistry of Cynomolgus monkeys that are needed for proper clinical diagnosis and biomedical research conduct. The body weight information and blood type are also key success factors in allogeneic or xenogeneic models.

Clinical Implications of Femoral Anthropometrical Features for Total Knee Arthroplasty in Koreans.

Anthropometric features of Asians femora and their clinical relevance with regard to TKA are not rigorously investigated. We attempted to determine how well current prostheses accommodate femoral anthropometric features of Koreans and whether the presence of condylar or trochlear overhang or underhang adversely affects functional outcomes. We hypothesized that current prostheses do not accommodate Korean female femora well, and that overhang or underhang would adversely affect outcomes.

Assessment of early renal allograft dysfunction with blood oxygenation level-dependent MRI and diffusion-weighted imaging.

Purpose: To investigate blood oxygenation level-dependent (BOLD) MRI and diffusion-weighted imaging (DWI) at 3 T for assessment of early renal allograft dysfunction.

Materials And Methods: 34 patients with a renal allograft (early dysfunction, 24; normal, 10) were prospectively enrolled. BOLD MRI and DWI were performed at 3 T.

Correlation between static radiographic measurements and intersegmental angular measurements during gait using a multisegment foot model.

Background: Radiographic examination is a widely used evaluation method in the orthopedic clinic. However, conventional radiography alone does not reflect the dynamic changes between foot and ankle segments during gait. Multiple 3-dimensional multisegment foot models (3D MFMs) have been introduced to evaluate intersegmental motion of the foot.

Repeatability of a multi-segment foot model with a 15-marker set in healthy adults.

Background: Several 3D multi-segment foot models (MFMs) have been introduced for the in vivo analysis of dynamic foot kinematics. However, reproducibility of a model should be checked and ascertained before clinical utilization of a MFM. The purpose of this study was to determine the reliability of recently introduced MFM with a 15-marker set by assessing the participant's stride-to-stride (intra-session) and visit-to-revisit (inter-session) repeatability.

Post-metastasis survival in extremity soft tissue sarcoma: a recursive partitioning analysis of prognostic factors.

Background: Recursive partitioning analysis (RPA) enables grouping of patients into homogeneous prognostic groups in a visually intuitive form and has the capacity to account for complex interactions among prognostic variables. In this study, we employed RPA to generate a prognostic model for extremity soft tissue sarcoma (STS) patients with metastatic disease.

Methods: A retrospective review was conducted on 135 patients with metastatic STS who had undergone surgical removal of their primary tumours.

Prediction of chronicity of anterior cruciate ligament tear using MRI findings.

Background: The estimation of anterior cruciate ligament (ACL) tear is required in certain cases involving legal and financial administration, such as the worker's compensation and/or insurance. The aim of this study is to propose and evaluate a quantitative evaluation instrument to estimate the chronicity of the ACL tear, based on the four magnetic resonance imaging (MRI) findings.

Methods: One hundred and fifty one cases of complete ACL tear confirmed by arthroscopy were divided into 4 groups according to the time from ACL injury to MRI acquisition: acute (< 6 weeks), subacute (6 weeks to 3 months), intermediate (3 months to 1 year), and chronic (> 1 year).

Photoplethysmography and continuous-wave Doppler ultrasound as a complementary test to ankle-brachial index in detection of stenotic peripheral arterial disease.

Purpose: We evaluated the sensitivity and specificity of ankle-brachial index (ABI), photoplethysmography (PPG), and continuous-wave Doppler ultrasound (CWD) in the detection of anatomically stenotic peripheral arterial disease (PAD).

Methods: Ninety-seven patients (194 legs) patients who had coincidentally undergone computed tomography angiography (CTA), ABI, PPG, and CWD for the evaluation of PAD were retrospectively reviewed. Sensitivity and specificity were measured.

Evaluation of transplanted kidneys using blood oxygenation level-dependent MRI at 3 T: a preliminary study.

Objective: The objective of our study was to investigate the feasibility and reproducibility of blood oxygenation level-dependent (BOLD) MRI using different gradient echoes at 3 T in patients with renal allografts and healthy volunteers and to evaluate whether BOLD MRI can be used to distinguish between cases of acute allograft rejection and normally functioning allografts.

Subjects And Methods: BOLD MRI at 3 T was performed of eight patients with normal allografts, four patients with acute allograft rejection, and 10 healthy volunteers. Multiple fast-field echo sequences were performed at gradient echoes of 8, 16, and 20 to obtain T2(*)-weighted images.

Pain management by periarticular multimodal drug injection after anterior cruciate ligament reconstruction: a randomized, controlled study.

Purpose: We aimed to determine the efficacy of periarticular (PA) multimodal drug cocktail (MDC) infiltration for pain control after anterior cruciate ligament reconstruction with an autogenous bone-patellar tendon-bone graft.

Methods: We randomly assigned 100 patients to five study groups (20 per group): control group, no injection; intra-articular (IA) ropivacaine group, IA injection of ropivacaine alone; IA MDC group, IA injection of MDC; PA MDC group, PA injection of MDC; and IA + PA MDC group, IA and PA injections of MDC. The MDC consisted of ropivacaine, morphine, ketorolac, epinephrine, and cefuroxime.

Clinical and genetic factors affecting tacrolimus trough levels and drug-related outcomes in Korean kidney transplant recipients.

Purpose: The purpose of this study was to characterize the effects of clinical and genetic variables on the pharmacokinetics and complications of tacrolimus during the first year after kidney transplantation.

Methods: One hundred and thirty-two Korean kidney recipients who received tacrolimus were genotyped for ABCB1 (exons 12, 21, and 26) and CYP3A5 (intron 3). Tacrolimus trough levels, dose, or dose-adjusted trough levels and complications were compared among patients during the early stage (3, 7, 14, 30, and 90 days) and up to 1 year according to the genotypes.

Evaluation of the MicroScan MICroSTREP plus antimicrobial panel for testing β-hemolytic streptococci and viridans group streptococci.

Background: In order to determine the clinical usefulness of the MicroScan (Siemens Healthcare Diagnostics, USA) MICroSTREP plus antimicrobial panel (MICroSTREP) for testing antimicrobial susceptibility of β-hemolytic streptococci (BHS) and viridans group streptococci (VGS), we compared the accuracy of MICroSTREP with that of the CLSI reference method.

Methods: Seventy-five BHS and 59 VGS isolates were tested for antimicrobial susceptibility to ampicillin, penicillin, cefotaxime, meropenem, erythromycin, clindamycin, levofloxacin, and vancomycin by using MICroSTREP and the CLSI agar dilution method.

Results: The overall essential agreement with regard to minimum inhibitory concentrations (MICs) (within ±1 double dilution) between MICroSTREP and the CLSI reference method was 98.

Outcome of rotator cuff repair in large-to-massive tear with pseudoparalysis: a comparative study with propensity score matching.

Background: Active range of motion deficit is one of the alleged negative influencing factors of rotator cuff repair. Recently, with the popularity of reverse total shoulder arthroplasty (RTSA), there is a tendency toward performing RTSA in cases of nonarthritic large-to-massive tears with pseudoparalysis.

Hypothesis: Rotator cuff repair in patients with active motion deficit may yield inferior outcome.

Statistical consideration for bilateral cases in orthopaedic research.

Background: Statistical independence means that one observation is not affected by another; however, the principle of statistical independence is violated if left and right-side measures within a subject are considered to be independent, because they are usually correlated and can affect each other. The purpose of the present study was to analyze the violation of statistical independence in recent orthopaedic research papers and to demonstrate the effect of statistical analysis that considered the data dependency within a subject.

Methods: First, all original articles that had been published in The Journal of Bone and Joint Surgery (American Volume) over a two-year period were evaluated.

Follicular stimulating hormone enhances Notch 1 expression in SK-OV-3 ovarian cancer cells.

Objective: Notch is known as a transmembranous receptor family with four homologous forms - Notch 1, Notch 2, Notch 3, and Notch 4 and related to cell fate regulation and angiogenesis. The purpose is to investigate the effect of follicular stimulating hormone (FSH) on the Notch 1 expression and proliferation in ovarian cancer cells.

Methods: Human ovarian cancer cell line, SK-OV-3 and FSH were used.

Gender differences in the correlation between symptom and radiographic severity in patients with knee osteoarthritis.

Background: The effects of gender on the relationship between symptom manifestations and radiographic grades of knee osteoarthritis are not well understood.

Questions/purposes: We therefore determined the increments of symptom progression with regard to radiographic grades of knee osteoarthritis and asked if those increments differed by gender and whether symptom severity was differentially manifested by gender within the same grade.

Methods: We recruited 660 community residents; 368 (56%) women and 292 (44%) men.

Correlation of magnetic resonance imaging findings with the chronicity of an anterior cruciate ligament tear.

Background: Although several findings on magnetic resonance imaging have been demonstrated after anterior cruciate ligament injury, sequential changes on magnetic resonance imaging have not been comprehensively studied. We undertook to correlate four specific findings on magnetic resonance imaging of an anterior cruciate ligament injury over time.

Methods: One hundred and forty-five patients with a complete tear of the anterior cruciate ligament confirmed by arthroscopy were divided, according to the time from the injury to the acquisition of the magnetic resonance image, into four groups: acute (within six weeks), subacute (more than six weeks to three months), intermediate (more than three months to one year), and chronic (more than one year).

Correlations between commonly used clinical outcome scales and patient satisfaction after total knee arthroplasty.

Unlabelled: Patient satisfaction is becoming increasingly important as a crucial outcome measure for total knee arthroplasty. We aimed to determine how well commonly used clinical outcome scales correlate with patient satisfaction after total knee arthroplasty. In particular, we sought to determine whether patient satisfaction correlates better with absolute postoperative scores or preoperative to 12-month postoperative changes.

Improved early clinical outcomes of RP/PS mobile-bearing total knee arthroplasties.

Unlabelled: The rotating-platform posterior-stabilized (RP/PS) prosthesis was developed to take advantage of the benefits of the traditional RP mobile-bearing system and the posterior-stabilized design. This nonconsecutive cohort study compared the clinical outcomes of TKAs performed using a RP/PS mobile system or a floating-platform (FP) system. The clinical outcomes of 93 TKAs with a RP/PS prosthesis were compared with the same number of TKAs with a FP mobile-bearing prosthesis at 6, 12, and 24 months after surgery.

Differences between sagittal femoral mechanical and distal reference axes should be considered in navigated TKA.

In computer-assisted TKA, surgeons determine positioning of the femoral component in the sagittal plane based on the sagittal mechanical axis identified by the navigation system. We hypothesized mechanical and distal femoral axes may differ on lateral views and these variations are influenced by anteroposterior bowing and length of the femur. We measured angles between the mechanical axis and distal femoral axis on 200 true lateral radiographs of the whole femur from 100 adults.

Clinical value of regular passive ROM exercise by a physical therapist after total knee arthroplasty.

Regular passive ROM exercise (PROME) by a physical therapist is often incorporated in rehabilitation protocols after total knee arthroplasty (TKA). This randomized, controlled trial examined whether or not the incorporation of PROME to a postoperative rehabilitation protocol would offer a better clinical outcome after TKA. Fifty consecutive patients who underwent bilateral TKAs staged 2 weeks apart received PROME for one knee and not for the other.

Causes and predictors of patient's dissatisfaction after uncomplicated total knee arthroplasty.

We aimed to identify the causes and predictors of patient's dissatisfaction after total knee arthroplasty (TKA). Patient's satisfaction was evaluated in 438 TKAs. Causes of patient dissatisfaction were identified using patient interview, physical examinations, laboratory and radiographic tests, and relevant medical consultations.