Publications by authors named "Sung-Hun Lee"

Article Synopsis
  • - Gastric cancer ranks as the fifth most common cancer worldwide and is the fourth leading cause of cancer-related deaths; early detection remains challenging despite existing diagnostic methods like esophagogastroduodenoscopy with biopsy.
  • - Recent research is focusing on liquid biopsy techniques to diagnose gastric cancer by analyzing specific cancer-derived substances found in blood, although these substances are present in very small quantities and vary significantly among individuals and cancer types.
  • - The study collected and analyzed methylated DNA fragments from both cancer tissue and patient's plasma, revealing a 41.2% consistency rate in identifying common methylated fragments, suggesting potential for improved diagnosis and characterization of gastric cancer.
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Background: This study aimed to identify the specific T cell co-stimulatory and co-inhibitory factors that play prognostic roles in patients with glioblastoma. Additionally, the unique histone H3 modification enzymes that regulate the expression levels of these specific co-stimulatory and co-inhibitory factors were investigated.

Methods: The medical records of 84 patients newly diagnosed with glioblastoma at our institution from January 2006 to December 2020 were retrospectively reviewed.

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Recently, liquid biopsies have been used to diagnose various diseases, including cancer. Body fluids contain many substances, including cells, proteins, and nucleic acids originating from normal tissues, but some of these substances also originate from the diseased area. The investigation and analysis of these substances in the body fluids play a pivotal role in the diagnosis of various diseases.

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Article Synopsis
  • - Early detection of cancer is crucial, and plasma cell-free DNA (cfDNA) can reveal tumor DNA signatures for diagnosing early-stage tumors.
  • - The novel TOF (Tumor Originated Fragment) method quantifies tumor fragments by analyzing cfDNA methylation patterns and specific fragmentomic features to improve lung cancer diagnosis.
  • - In a study with 298 plasma samples, the TOF method successfully distinguished lung cancer patients from healthy individuals, achieving an impressive accuracy rate with a score of 0.98 out of 1.0.
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Natural rubber (NR) presents a number of advantages over other types of rubber but has poor resistance to chemicals and aging. The incorporation of ethylene propylene diene monomer (EPDM) into the NR matrix may be able to address this issue. Mineral fillers, such as carbon black (CB) and silica are routinely incorporated into various elastomers owing to their low cost, enhanced processability, good functionality, and high resistance to chemicals and aging.

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In this study, we compare various solvents with different Gutmann donor numbers as additives to improve the quality of perovskite films via an antisolvent-free process, using 2-methoxyethanol (2MOE) as the solvent. In 2MOE-based solutions, we found that the higher the donor number of the solvent, the lower the amount of the solvent required to form insoluble adducts. Furthermore, we found that -methyl-2-pyrrolidone (NMP), which has a relatively low donor number and vapor pressure, can be added without a limitation to precipitation, while the degree of the intermediate phase in the as-deposited film is controlled by the amount of NMP added.

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Purpose: This study aimed to investigate the methylation status of major histone modification sites in primary central nervous system lymphoma (PCNSL) samples and examine their prognostic roles in patients with PCNSL.

Materials And Methods: Between 2007 and 2020, 87 patients were histopathologically diagnosed with PCNSL. We performed immunohistochemical staining of the formalin-fixed paraffin-embedded samples of PCNSL for major histone modification sites, such as H3K4, H3K9, H3K27, H3K14, and H3K36.

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Rubber compounding with two or more components has been extensively employed to improve various properties. In particular, natural rubber (NR)/ethylene-propylene-diene monomer rubber (EPDM) blends have found use in tire and automotive parts. Diverse fillers have been applied to NR/EPDM blends to enhance their mechanical properties.

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This study aimed to identify the expression profile of circulating microRNAs in dogs with eccentric or concentric cardiac hypertrophy. A total of 291 microRNAs in serum samples of five dogs with myxomatous mitral valve degeneration (MMVD) and five dogs with pulmonic stenosis (PS) were compared with those of five healthy dogs using microarray analysis. Results of microarray analysis revealed up-regulation of cfa-miR-130b [fold change (FC) = 2.

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Purpose: The objective of this study was to investigate the epigenetic role of histone lysine methylation/demethylation on the expression of epithelial-to-mesenchymal transition (EMT) associated transcriptional factors (TFs) during the metastasis of lung adenocarcinoma to the brain.

Methods: Paired samples of lung adenocarcinoma and brain metastasis (BM) were analyzed in 46 individual patients. Both samples were obtained by surgical resection or biopsy of the lung and brain.

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Background: Early diagnosis and continuous monitoring are necessary for an efficient management of cervical cancers (CC). Liquid biopsy, such as detecting circulating tumor DNA (ctDNA) from blood, is a simple, non-invasive method for testing and monitoring cancer markers. However, tumor-specific alterations in ctDNA have not been extensively investigated or compared to other circulating biomarkers in the diagnosis and monitoring of the CC.

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Methanol is an attractive energy source due to its portability and thermodynamic coke resistance by its oxygen content. In order to operate dry methanol fuel low temperature solid oxide fuel cells (LT-SOFCs), it is important to solve the problems of carbon formation and its low performance. In this study, copper impregnation was selected to decrease the carbon deposition and enhance the performance at low temperature.

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This study is to observe the developmental process of the larval skeleton according to the growth of the trident goby, belonging to the larvae and juveniles and use it as the basic data of the taxonomic study. 8 days after hatching, the parasphenoid was ossified with an average total length of 3.62 mm, and basioccipital began to ossify.

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This study was conducted to investigate the skeletal development of bullhead torrent catfish, larvae and to utilize them as basic data for the taxonomic study of larvae. Skeletal development was observed by being divided into cranium, visceral skeleton, shoulder girdle bone, pelvic girdle bone and vertebra. On the first day after hatching, the pre-larvae had an average total length of 7.

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The stemness maintenance of embryonic stem cells (ESCs) requires pluripotency transcription factors, including Oct4, Nanog, and Sox2. We have previously reported that protein arginine methyltransferase 7 (PRMT7), an epigenetic modifier, is an essential pluripotency factor that maintains the stemness of mouse ESCs, at least in part, by down-regulating the expression of the anti-stemness microRNA (miRNA) miR-24-2. To gain greater insight into the molecular basis underlying PRMT7-mediated maintenance of mouse ESC stemness, we searched for new PRMT7-down-regulated anti-stemness miRNAs.

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Self-renewal and pluripotency are two fundamental characteristics of embryonic stem cells (ESCs) and are controlled by diverse regulatory factors, including pluripotent factors, epigenetic regulators and microRNAs (miRNAs). Although histone methyltransferases are key epigenetic regulators, whether and how a histone methyltransferase forms a network with miRNAs and the core pluripotent factor system to regulate ESC stemness is little known. Here, we show that the protein arginine methyltransferase 7 (PRMT7) is a pluripotent factor essential for the stemness of mouse ESCs.

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OBJECTIVE The purpose of the present study was to investigate the epigenetic and prognostic roles of an H3K4 methyltransferase (mixed lineage leukemia 4 [MLL4]) and H3K27 demethylase (ubiquitously transcribed tetratricopeptide repeat gene on X chromosome [UTX]) in progression-free survival (PFS) and overall survival (OS) of patients with glioblastoma (GBM) who were treated with radiotherapy, chemotherapy, or both after resection. In addition, the authors examined methylation at the promoter of the O-6-methylguanine-DNA methyltransferase ( MGMT) gene and other prognostic factors predicting length of PFS and OS in these patients. METHODS The medical records of 76 patients having a new diagnosis of histologically ascertained GBM in the period of January 2002 to December 2013 at the authors' institution were retrospectively reviewed.

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We studied the electrochemical characteristics of tin dioxide (SnO2) recovered from waste catalyst material which had been previously used in a polymer synthesis reaction. In order to improve the electrochemical performance of the SnO2 anode electrode, we synthesized a nanocomposite of recovered SnO2 and commercial iron oxide (Fe2O3) (weight ratio 95:5) using a solid state method. X-ray diffraction (XRD) and field emission scanning electron microscopy (FE-SEM) analyses revealed an additional iron oxide phase within a porous nanocomposite architecture.

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Trimethylated histone H3 lysine 27 (H3K27me3) is linked to gene silencing, whereas H3K4me3 is associated with gene activation. These two marks frequently co-occupy gene promoters, forming bivalent domains. Bivalency signifies repressed but activatable states of gene expression and can be resolved to active, H3K4me3-prevalent states during multiple cellular processes, including differentiation, development and epithelial mesenchymal transition.

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A variety of surgical approaches to temporal horn tumors of the lateral ventricle have been described. Magnetic resonance imaging (MRI) and angiography are the preferred modalities for preoperative evaluation and provide important information for the choice of surgical approach. A 59-year-old man was referred to our hospital due to confusion and gait disturbance.

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Alteration of apoptosis is related with progression and recurrence of atypical meningiomas (AMs). However, no comprehensive study has been conducted regarding histone modification regulating apoptosis in AMs. This study aimed to determine the prognostic values of certain apoptosis-associated factors, and examine the role of histone modification on apoptosis in AMs.

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In order to monitor the developmental features of embryos, larvae, and juveniles of Oryzias latipes (Temminck and Schlegel), Oryzias latipes was caught in river of Shinduck-dong, Yeosu-si, Jeollanam-do, on May 2011, and experiments were carried out in Ichthyology laboratory at Chonnam National University. The blastodisc step was the first level for natural spawning. The optic vesicle, Kupffer's vesicle, myotome began to appear 75 hours 57 minutes later.

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Long interspersed nuclear element-1 (LINE-1 or L1) retrotransposons are insertional mutagens capable of altering the genomic landscape in many ways. Activation of the normally silent LINE-1 retrotransposon is associated with a high level of cancer-associated DNA damage and genomic instability. Studies of LINE-1 have so far focused mainly on changes in gene expression, and our knowledge of its impact on functional non-coding RNAs is in its infancy.

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Object: The aim of this study was to evaluate the role of certain cell-cycle regulatory proteins in the recurrence of atypical meningiomas. These proteins were analyzed with immunohistochemical staining to identify predisposing factors for the recurrence of atypical meningiomas.

Methods: The authors retrospectively reviewed the medical records of patients with atypical meningiomas diagnosed in the period from January 2000 to June 2012 at the Department of Neurosurgery at Samsung Changwon Hospital and Dong-A University Medical Center.

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