Publications by authors named "Sung-A Chang"
Article Synopsis
- Osimertinib, a treatment for advanced non-small cell lung cancer, demonstrated a 4.7% incidence of cardiotoxicity in real-world settings, raising concerns about its long-term safety.
- The study analyzed 1,126 patients and identified risk factors for cardiotoxicity, including older age, previous heart failure, atrial fibrillation, and low left ventricle strain.
- A high recovery rate of 82.4% for cardiac dysfunction was observed, indicating potential reversibility, but emphasizes the need for careful monitoring in at-risk patients.
Background And Objectives: The transformation of pulmonary arterial hypertension (PAH) treatment in Korea, ushered by targeted therapy's advent, prompted our analysis of baseline attributes, treatment trends, and survival shifts within our single-center registry.
Methods: We examined 230 patients (72.6% female, mean age 40.
This brief report reviews the clinical, procedural, and imaging data of 7 patients with p.Arg4810Lys variant of the ring finger protein 213 (RNF213) gene-related peripheral pulmonary arterial stenosis who underwent percutaneous transluminal pulmonary angioplasties (PTPAs) for demographics, clinical presentation, indications for angioplasty, and procedural and clinical outcomes. During median follow-up of 64.
View Article and Find Full Text PDFBackground And Objectives: The recent developments in chronic thromboembolic pulmonary hypertension (CTEPH) are emphasizing the multidisciplinary team. We report on the changes in clinical practice following the development of a multidisciplinary team, based on our 7 years of experience.
Methods: Multidisciplinary team was established in 2015 offering both balloon pulmonary angioplasty (BPA) and pulmonary endarterectomy (PEA) with technical upgrades by internal and external expertise.
Article Synopsis
- Aortic stenosis (AS) is common in older adults and more patients will need noncardiac surgeries, yet research on complications specifically in asymptomatic significant AS patients is limited.
- A study analyzed 221 patients with asymptomatic significant AS and found no significant difference in major cardiovascular events compared to a control group undergoing similar surgeries.
- Advanced cardiac damage stage in patients with significant AS emerged as a crucial factor influencing the risk of complications during noncardiac surgery.
Article Synopsis
- Chronic thromboembolic pulmonary disease (CTEPD) can restrict exercise even when patients show normal right ventricular (RV) function or no pulmonary hypertension at rest, making the combination of exercise stress echocardiography and cardiopulmonary exercise testing (ESE-CPET) valuable for evaluation.
- In a study involving 50 CTEPD patients with mild disease, results showed decreased maximal oxygen consumption (peak VO) and a significant increase in RV systolic pressure (RVSP) during exercise, indicating altered heart responses to physical activity.
- The findings suggest that patients with mild pulmonary hypertension or no hypertension still experience exercise limitations, with RV dysfunction becoming evident during exercise, particularly in those with impaired exercise capacity.
Article Synopsis
- Early atrial fibrillation (AF) events during the blanking period after total thoracoscopic ablation (TTA) are associated with a higher risk of late AF recurrence, highlighting the importance of monitoring these patients.
- In a study of 128 patients, 32.8% experienced early recurrence (ER) of AF, which significantly increased their risk of AF recurrence over 5 years compared to those without ER.
- Among patients with ER, left atrial (LA) strain proved to be an independent predictor of long-term AF recurrence, with those having LA strain below 18.6% showing a much higher risk of recurrence.
Background: Recently, a ring-type cuffless blood pressure (BP) measuring device has been developed. This study was a prospective, single arm, first-in-human pivotal trial to evaluate accuracy of BP measurement by the new device.
Methods: The ring-type smart wearable monitoring device measures photoplethysmography signals from the proximal phalanx and transmits the data wirelessly to a connected smartphone.
Article Synopsis
- A study investigated the incidence and prognostic implications of chronic kidney disease (CKD) and metabolic syndrome (MS) in adult congenital heart disease (ACHD) patients, using data from 2,462 individuals over 12 years.
- The results showed that the incidence rates for CKD and MS were 7.6% and 35.9%, respectively, with a coexistence rate of 4.6%.
- CKD was linked to a significantly higher risk of mortality, and while MS wasn't independently connected to mortality, it was found to be closely related to the presence of CKD, suggesting the need for careful monitoring and management of these conditions in ACHD patients.
Background: Despite the 2015 American College of Medical Genetics and Genomics (ACMG) and Association of Molecular Pathology (AMP) guideline, many variants of gene remain inconclusive. In line with publication of the specific variant interpretation guideline by ClinGen in 2022, we reassessed variants of uncertain significance (VUS) in gene found in our institution.
Methods: VUS found in the course of sequencing between December 2015 and April 2022 were reassessed based on -specific variant interpretation guideline, review of updated literatures and additional genetic tests including family study and/or RNA study if available.
Purpose: This regulatory post-marketing surveillance (PMS) was organized to identify the safety and effectiveness of ambrisentan in the Korean population.
Method: This was an open-label, multi-center PMS conducted from 31 institutions in Korea for 6 years from August 2015 to 2021, to evaluate the use of ambrisentan for the treatment of pulmonary arterial hypertension (PAH). Inclusion criteria are Korean subjects with the World Health Organization functional classification (WHO Fc) II or III PAH who are new users or repeated users with ambrisentan (Volibris®) Tablet 5 or 10 mg per day (age >18 years old).
Article Synopsis
- A study investigated the role of left atrial appendage emptying velocity (LAAV) as a predictor of atrial fibrillation (AF) recurrence in patients undergoing totally thoracoscopic ablation (TTA).
- Data was collected from 129 patients who underwent TTA, with findings indicating that lower LAAV was linked to higher rates of AF recurrence over a 3-year follow-up.
- Patients with a LAAV below 20 cm/s had significantly worse event-free survival compared to those with higher LAAV, suggesting LAAV can help identify patients at risk for AF recurrence post-TTA.
Article Synopsis
- The study investigates the impact of pericardial calcification patterns on the success of pericardiectomy for treating constrictive pericarditis (CP).
- Researchers analyzed preoperative CT scans and medical records of 98 patients who underwent the surgery from 2010 to 2020.
- Results indicate that patients with lower pericardial calcium scores experienced a higher rate of cardiovascular events post-surgery, suggesting that lower calcification may lead to worse outcomes.
Background: Pulmonary veno-occlusive disease (PVOD) and/or pulmonary capillary hemangiomatosis (PCH) are rare causes of pulmonary hypertension. Pulmonary arterial hypertension (PAH) and PVOD/PCH are clinically similar, but there is a risk of drug-induced pulmonary edema when PCH patients receive the PAH therapy. Therefore, early diagnosis of PVOD/PCH is important.
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- Left atrial (LA) fibrosis severity is linked to atrial fibrillation (AF) recurrence, with a study examining this relationship in patients who had thoracoscopic ablation surgery for AF.
- Among 128 patients, those with mild LAA fibrosis experienced lower AF recurrence rates (23.3%) compared to those with moderate (51.4%) and severe fibrosis (53.2%).
- The only significant predictor of mild fibrosis was peak LA strain, with a cutoff of 14.7%, indicating that higher strain levels correlate with better outcomes and lower AF recurrence risk after 5 years.
We aimed to evaluate the additive value of cardiovascular magnetic resonance imaging (CMR) and cardiopulmonary exercise test (CPET) to predict clinical outcomes in patients with HCM. We enrolled 373 patients with HCM and normal left ventricular systolic function who underwent CPET and CMR. The primary outcome was a clinical composite of all-cause death, cardiac transplantation, stroke, heart failure requiring hospitalization and defibrillator implantation.
View Article and Find Full Text PDFBackground And Objectives: Several cases involving severe right ventricular (RV) failure in advanced cancer patients have been found to be pulmonary tumor thrombotic microangiopathies (PTTMs). This study aimed to discover the nature of rapid RV failure syndrome with a suspected diagnosis of PTTM for better diagnosis, treatment, and prognosis prediction in clinical practice.
Methods: From 2011 to 2021, all patients with clinically suspected PTTM were derived from the one tertiary cancer hospital with more than 2000 in-hospital bed.
Aims: To investigate whether left arterial reservoir strain (LASr) could predict new-onset atrial fibrillation (NOAF) in patients with light-chain-type cardiac amyloidosis (ALCA).
Methods And Results: This study enrolled 427 patients with CA from two tertiary centres between 2005 and 2019. LASr was measured using a vendor-independent analysis programme.
Background And Objective: Macitentan is approved for treating pulmonary arterial hypertension. However, the real-world evidence of macitentan use is limited. Therefore, we evaluated the safety and clinical outcomes of macitentan use in clinical practice under a post-marketing surveillance.
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- - The study investigates long-term cardiac and cerebrovascular risks in patients with hypertrophic cardiomyopathy (HCM) who have apical aneurysms (AAn), finding that AAn occurs in about 9.2% of patients.
- - Patients with AAn experience higher rates of major adverse cardiac and cerebral events (MACCEs) compared to those without AAn, particularly noting a significant difference in the rate of cerebrovascular accidents.
- - Larger AAn (Grade 2) correlates to an even greater risk of MACCEs, emphasizing that AAn significantly heightens the chances of adverse health outcomes, especially strokes, in patients with HCM.
Article Synopsis
- The study assessed the effectiveness of transesophageal contrast echocardiography (TECE) with the agitated saline test for diagnosing pulmonary arteriovenous malformations (PAVMs), comparing it to traditional methods like chest CT and pulmonary angiography.
- Out of 1,809 patients tested, 387 showed signs of PAVMs, with results indicating that TECE's grading system helps identify the severity and presence of PAVMs, with positive predictive values increasing with higher grades.
- The conclusion highlighted that TECE is a valuable diagnostic tool for non-HHT patients suspected of having PAVMs, suggesting those with lower grade findings might avoid unnecessary radiation exposure from further imaging tests.
Aims: Tricuspid valve (TV) surgery for functional tricuspid regurgitation (TR) is becoming more common, but the associated mortality remains high. Therefore, we evaluated the clinical and echocardiographic parameters associated with all-cause mortality in patients with severe functional TR who underwent TV surgery.
Methods And Results: A total of 286 patients with severe functional TR who underwent TV replacement or repair was analysed between January 2006 and December 2017.
Hypertrophic cardiomyopathy (HCM) is one of the most common inheritable cardiomyopathies. Contemporary management strategies, including the advent of implantable cardioverter-defibrillators and effective anticoagulation, have substantially improved the clinical course of HCM patients; however, the disease burden of HCM is still high in Korea. Sudden cardiac death (SCD), atrial fibrillation and thromboembolic risk, dynamic left ventricular outflow tract (LVOT) obstruction, and heart failure (HF) progression remain important issues in HCM.
View Article and Find Full Text PDFBackground: Optimizing an individual dose with careful management of adverse events (AEs) is essential in the treatment with selexipag approved for pulmonary arterial hypertension (PAH). This study aims to identify real-world practice patterns and AE characteristics of selexipag.
Research Design And Methods: This multicenter, longitudinal, observational study included Korean patients with PAH who initiated with selexipag and were followed up to 24 weeks.
Background: Few studies used nationwide data to assess the survival rates (SRs) and death risk for idiopathic pulmonary arterial hypertension (IPAH; ICD-10 I27.0) in Korea.
Methods: IPAH data (N = 9,017; female:male = 6:4) were collected from the National Health Insurance Service in Korea, from 2006 through 2017.