Publications by authors named "Sung Woo Cho"

Article Synopsis
  • * Data was collected from 952 patients, revealing a 2.2% incidence of vaccine-related adverse events (11 cases of myocarditis, 10 of pericarditis), most commonly following the Pfizer-BioNTech vaccine.
  • * Despite some patients experiencing symptoms and requiring hospitalization, overall prognosis remained favorable for all patients with mRNA-VRCS, with no significant differences noted in emergency room visits or mortality rates.
View Article and Find Full Text PDF

Medical stents are vital for treating vascular complications and restoring blood flow in millions of patients. Despite its widespread effectiveness, restenosis, driven by the complex interplay of cellular responses, remains a concern. This study investigated the reactions of vascular cells to nano/microscale wrinkle (nano-W and micro-W) patterns created on laser-textured nitinol (NiTi) surfaces by adjusting laser processing parameters, such as spot overlap ratio and line overlap ratio.

View Article and Find Full Text PDF

Background: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by persistent inflammatory cascades, with macrophage activation playing a pivotal role. Chitinase 1 (CHIT1), produced by activated macrophages, is a key player in this cascade. In this study, we aimed to explore the role of CHIT1 in MASH with progressive liver fibrosis.

View Article and Find Full Text PDF
Article Synopsis
  • Rheumatic heart disease (RHD) poses significant health risks, particularly in women, but this case examines its effects in a young Asian male with severe symptoms.
  • The 46-year-old patient, with a history of mitral valvuloplasty, presented with serious issues like severe mitral stenosis and tricuspid regurgitation, requiring surgical intervention.
  • The case illustrates the chronic nature of RHD and stresses the importance of regular follow-ups and a team approach in managing complex heart conditions for better outcomes.
View Article and Find Full Text PDF
Article Synopsis
  • Heart failure (HF) is a serious issue linked to obesity, diabetes, and cardiovascular diseases, prompting research on fenofibrate, a drug that may help improve heart function in these conditions.
  • In lab studies with mice, fenofibrate showed positive effects by reducing fibrosis and inflammation in the heart, and a real-world analysis indicated it lowered hospitalization risks for HF among users.
  • The results suggest fenofibrate could be an effective treatment for heart problems associated with obesity and diabetes, making it a potential asset in managing cardiomyopathy related to these conditions.
View Article and Find Full Text PDF

Objectives: To evaluate the treatment outcomes in patients with advanced-stage olfactory neuroblastoma (ONB) who received induction chemotherapy (IC).

Materials And Methods: The clinical data of 38 patients with advanced-stage ONB who received initial IC were retrospectively analyzed. The response was defined using the Response Evaluation Criteria in Solid Tumors version 1.

View Article and Find Full Text PDF

Objectives: Sinonasal squamous cell carcinoma (SqCC) often invades the orbit. The treatment approach for sinonasal cancer that has spread to the orbit varies across medical centers and depends on the extent of the invasion. The decision to preserve the orbit in the treatment strategy is made on a case-by-case basis and.

View Article and Find Full Text PDF

Background: Recent human and animal studies have demonstrated that Nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome is closely involved in the development of allergic diseases.

Objective: To identify the mechanism underlying the activation of NLRP3 inflammasome signaling pathway in an ovalbumin (OVA)-induced allergic rhinitis (AR) mice model and to validate the effect of a specific inhibitor of the NLRP3, MCC950.

Methods: Mice were divided into three groups and each group consisted of ten mice (saline group, the negative control group; OVA group, the OVA-induced AR model group; and OVA+MCC group, treated with 10 mg/kg MCC950).

View Article and Find Full Text PDF

The mechanism and predictive biomarkers of sinonasal inverted papilloma (IP) transformation into squamous cell carcinoma (SCC) are still unclear. We investigated the genetic mutations involved and the predictive biomarkers. Fourteen patients with SCC arising from IP and six patients with IPs without malignant transformation (sIP) were included.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the link between white blood cell (WBC) count and long-term health outcomes in patients diagnosed with vasospastic angina (VA), a condition related to coronary artery disease.
  • A total of 823 VA patients without significant coronary lesions were analyzed over an average follow-up period of 4.3 years, dividing them into two groups based on their WBC counts at diagnosis.
  • Results showed no major differences in overall adverse events between groups; however, higher WBC counts were linked to increased risks of cardiac death and myocardial infarction (MI), with elevated WBC being an independent predictor for MI.
View Article and Find Full Text PDF

Background And Aims: Cancer-associated fibroblasts (CAFs) play key roles in the tumor microenvironment. IgA contributes to inflammation and dismantling antitumor immunity in the human liver. In this study, we aimed to elucidate the effects of the IgA complex on CAFs in Pil Soo Sung the tumor microenvironment of HCC.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates changes in olfactory function after endoscopic endonasal skull base surgery, using various tests like the butanol threshold test and an olfactory questionnaire to evaluate patients' sense of smell post-surgery.
  • Patients were categorized based on their olfactory function before surgery, and after analyzing data from 108 patients, the olfactory questionnaire showed a strong correlation with other conventional tests.
  • Findings indicated that the olfactory questionnaire is highly effective for assessing subjective olfactory function post-surgery, particularly in relation to patient age and preoperative smell scores.
View Article and Find Full Text PDF

Objectives: Due to the rarity of olfactory neuroblastoma (ONB), there is ongoing debate about optimal treatment strategies, especially for early-stage or locally advanced cases. Therefore, our study aimed to explore experiences from multiple centers to identify factors that influence the oncological outcomes of ONB.

Methods: We retrospectively analyzed 195 ONB patients treated at nine tertiary hospitals in South Korea between December 1992 and December 2019.

View Article and Find Full Text PDF

Objectives: This study aimed to evaluate the characteristics and treatment outcomes of inverted papillomas involving the frontal sinus.

Methods: Patients treated for inverted papilloma involving the frontal sinus between 2003 and 2020 were reviewed. Tumors were classified based on their extent (Extent 1: partially encroaching on the frontal sinus; Extent 2: completely filling the frontal sinus; Extent 3: eroding bony borders beyond the frontal sinus) and site of origin (Origin 1: originating outside the frontal sinus and prolapsing into the frontal sinus; Origin 2: originating from the frontal sinus walls medial to the vertical plane of the lamina papyracea; Origin 3: originating from the frontal sinus walls lateral to the vertical plane of the lamina papyracea).

View Article and Find Full Text PDF

Importance: Consumer-level sleep analysis technologies have the potential to revolutionize the screening for obstructive sleep apnea (OSA). However, assessment of OSA prediction models based on in-home recording data is usually performed concurrently with level 1 in-laboratory polysomnography (PSG). Establishing the predictability of OSA using sound data recorded from smartphones based on level 2 PSG at home is important.

View Article and Find Full Text PDF

Cerebral ischemia induces massive mitochondrial damage, leading to neuronal death. The elimination of damaged mitochondria via mitophagy is critical for neuroprotection. Here we show that the level of PA2G4/EBP1 (proliferation-associated 2G4) was notably increased early during transient middle cerebral artery occlusion and prevented neuronal death by eliciting cerebral ischemia-reperfusion (IR)-induced mitophagy.

View Article and Find Full Text PDF

Objectives: Several criteria exist for classifying chronic rhinosinusitis with nasal polyps (CRSwNP) as eosinophilic or non-eosinophilic. This study attempted to evaluate several criteria for defining eosinophilic CRSwNP from clinical and immunological perspectives.

Methods: A cohort of 84 patients (73 patients with CRSwNP and 11 control patients) was retrospectively analyzed.

View Article and Find Full Text PDF

Background And Objectives: Sternberg's canal is known to result from incomplete fusion of bony compartments constituting the sphenoid bone during the developmental process. This study aimed to evaluate the prevalence and clinical implications of Sternberg's canal.

Methods: A retrospective review of patients over the age of 18 years who had undergone endoscopic sinus surgery from 2014 to 2019 at a single institution was performed.

View Article and Find Full Text PDF
Article Synopsis
  • Oxidative stress is a key factor in Parkinson's disease (PD) development, and the role of the protein PIM2, known for its cell survival benefits by inhibiting reactive oxygen species (ROS), is still unclear in the context of PD.
  • The study aimed to assess the protective effects of PIM2 against cell death in dopaminergic neurons caused by oxidative stress through the use of a modified PIM2 protein delivered into human neural cells.
  • Results showed that the modified PIM2 (Tat-PIM2) reduced ROS levels and prevented neuronal apoptosis, indicating its potential as a therapeutic agent for protecting against dopaminergic neuron loss in PD.
View Article and Find Full Text PDF

Hypothesis: The introduction of functional interlayers for efficient anchoring of lithium polysulfides has received significant attention worldwide.

Experiments: A facile wet-chemical method was adopted to obtain hollow porous carbon nanospheres (HPCNSs) impregnated with metallic and polar cobalt sulfide (CoS) nanocrystals (abbreviated as "CoS@HPCNS"). The prepared nanocrystals were employed as electrocatalytic interlayers via separator coating for the efficient capture and reutilization of polysulfide species in Li-S batteries.

View Article and Find Full Text PDF