Publications by authors named "Sung Wei Tan"
J Transl Med
October 2023
Article Synopsis
- Dilated cardiomyopathy (DCM) is a serious heart disease leading to heart failure, with familial DCM being its major form, often linked to mutations in the LMNA gene.
- In this study, researchers tested 14 potential therapeutic candidates in a cardiac model of LMNA DCM to evaluate their effects on heart function, inflammation, fibrosis, and DNA damage.
- Results showed that several candidates improved cardiac function and survival, with specific candidates like Lamin C and Sun1 demonstrating long-term benefits, while Lamin A treatment raised concerns as it could worsen heart conditions in healthy individuals.
