Aspirin modulates inflammatory biomarkers in patients with subcortical silent brain infarcts.

Introduction: This study aimed to identify differences in the levels of inflammation-related biomarkers between patients with subcortical silent brain infarcts (SBIs) and healthy controls. We also evaluated the effect of aspirin on the subcortical SBI inflammatory processes.

Methods: Consecutive patients diagnosed with subcortical SBIs without a history of acute stroke were included.

Frequency-Dependent Vibrational Relaxation Time of OH Stretch at the Air/Isotopically Diluted Water Interface.

Elucidation of the vibrational relaxation process of interfacial water is indispensable for understanding energy dissipation at the aqueous interface. In this study, the vibrational relaxation dynamics of the hydrogen-bonded OH (HB OH) stretch vibration was investigated at the air/isotopically diluted water (HOD-DO) interface by time-resolved heterodyne-detected vibrational sum frequency generation (TR-HD-VSFG) spectroscopy. We observed the temporal change of the excited-state band ( = 1 → 2 transition), which enables a reliable determination of the time of interfacial water.

Effect of Whey Protein Isolate and Soy Protein Isolate on Textural Properties and Syneresis of Frozen Traditional Chinese Hot Pot Egg Sausage Gels.

Egg sausages, an essential component of traditional Chinese hot pot cuisine, have specific storage requirements and are predominantly distributed through refrigerated channels. A significant consideration in the freezing of egg sausages pertains to syneresis and textural modifications that manifest in the protein gel structure upon thawing. This research investigated the efficacy of incorporating whey protein isolate, soy protein isolate (at concentrations of 0.

Effect of Drying Time and Frying Conditions on the Quality of Pork Rinds by Response Surface Methodology.

Fried pork rind, a processed pork by-product, is popular as a snack globally, prized for its distinctive flavor and crisp texture achieved through frying. Although various studies have examined processing factors such as thickness, moisture content, and brine concentration, there is a scarcity of research addressing the effect of frying temperature on the quality of fried pork rinds. In the present study, the effects of varying hot air drying times (12, 18, and 24 h at 50°C), traditional deep-fat frying temperatures (180°C, 195°C, and 210°C), and frying durations (3, 4, and 5 min) on the oil content, moisture content, breaking force, color, puffing ratio, and microstructural appearance of pork rinds were evaluated.

The Effectiveness and Safety of Cupping Therapy on CV8 Shenque for Urticaria: A Systematic Review and Meta‑Analysis.

Background: Cupping therapy (CT) on acupoint CV8 Shenque is a potential treatment of urticaria. This review will analyze the efficacy and safety of CT on CV8 Shenque.

Methods: Randomized controlled trials (RCTs) comparing CT on CV8 Shenque with other treatments were retrieved from 14 worldwide databases from their inception to June 2024.

Prognostic models for progression-free survival in atypical meningioma: Comparison of machine learning-based approach and the COX model in an Asian multicenter study.

Background And Purpose: Atypical meningiomas are prevalent intracranial tumors with varied prognoses and recurrence rates. The role of adjuvant radiotherapy (ART) in atypical meningiomas remains debated. This study aimed to develop and validate a prognostic model incorporating machine learning techniques and clinical factors to predict progression-free survival (PFS) in patients with atypical meningiomas and assess the impact of ART.

UniVar: A variant interpretation platform enhancing rare disease diagnosis through robust filtering and unified analysis of SNV, INDEL, CNV and SV.

Background: Interpreting the pathogenicity of genetic variants associated with rare diseases is a laborious and time-consuming endeavour. To streamline the diagnostic process and lighten the burden of variant interpretation, it is crucial to automate variant annotation and prioritization. Unfortunately, currently available variant interpretation tools lack a unified and comprehensive workflow that can collectively assess the clinical significance of these types of variants together: small nucleotide variants (SNVs), small insertions/deletions (INDELs), copy number variants (CNVs) and structural variants (SVs).

SurVIndel2: improving copy number variant calling from next-generation sequencing using hidden split reads.

Deletions and tandem duplications (commonly called CNVs) represent the majority of structural variations in a human genome. They can be identified using short reads, but because they frequently occur in repetitive regions, existing methods fail to detect most of them. This is because CNVs in repetitive regions often do not produce the evidence needed by existing short reads-based callers (split reads, discordant pairs or read depth change).

Charge Inversion by Monovalent Hydroxide Ions.

The interaction between the hydroxide ion (OH) and the headgroup of a model cationic lipid (DPTAP, 1,2-dipalmitoyl-3-trimethylammonium-propane chloride) was investigated for different concentrations of NaOH solutions by using sum-frequency vibrational spectroscopy. The OH signal (3000-3700 cm) of the interfacial water under the Langmuir monolayer of DPTAP decreased with increasing NaOH concentration, due to screening of the surface charge by OH counterions. Surprisingly, after reaching a minimum at 5 mM NaOH, the OH signal steadily increased.

Constructing training sets for genomic selection to identify superior genotypes in candidate populations.

Approaches for constructing training sets in genomic selection are proposed to efficiently identify top-performing genotypes from a breeding population. Identifying superior genotypes from a candidate population is a key objective in plant breeding programs. This study evaluates various methods for the training set optimization in genomic selection, with the goal of enhancing efficiency in discovering top-performing genotypes from a breeding population.

Additive effect of clove essential oil combined with hydrogen inhalation improves psychological harm caused by lipopolysaccharide in mice.

Background: Psychological anxiety and depression, as well as memory impairment, are frequently linked to inflammation. Clove essential oil (CEO) administration and hydrogen (H) inhalation have been proven to have anti-inflammatory and alleviating effects on related psychological disorders in the past. The current study investigated the potential to improve anxiety-like behaviors and cognitive function by a combination of CEO and H treatment.

A narrative review of the challenges and impact of breast cancer treatment in older adults beyond cancer diagnosis.

Background And Objective: Breast cancer is the most prevalent cancer among women worldwide, with 45% of them over 65 years old. Older breast cancer patients tend to be underrepresented and understudied in major clinical trials. This narrative review provides a comprehensive overview of the current evidence regarding treatment decision-making, treatment toxicities, and proposed survivorship management recommendations for geriatric cancer patients.

Correlation of dynamic blood dose with clinical outcomes in radiotherapy for head-and-neck cancer.

Background And Purpose: Radiation-induced lymphopenia (RIL) during cancer radiotherapy is receiving growing attention due to its association with adverse clinical outcomes. Correlations between RIL and poorer locoregional control (LRC), distant-metastasis-free survival (DMFS), and overall survival (OS) have been demonstrated across multiple treatment sites. Estimates of radiation delivered to circulating blood or lymphocytes have been shown to be correlated with severe RIL.

NPS-1034 Exerts Therapeutic Efficacy in Renal Cell Carcinoma Through Multiple Targets of MET, AXL, and TNFRSF1A Signaling in a Metastatic Model.

Renal cell carcinoma (RCC) has diverse pathological subtypes, most of which have a poor prognosis. Patients with advanced RCC require systemic therapies for disease control. Although targeted therapies and immune checkpoint inhibitors have shown therapeutic efficacy, patients eventually succumb to disease progression.

Targeting the Adenosine A2A Receptor as a Novel Therapeutic Approach for Renal Cell Carcinoma: Mechanisms and Clinical Trial Review.

Renal cell carcinoma (RCC) accounts for nearly 2% of cancers diagnosed worldwide. For metastatic RCC, targeted therapy is one of the most common treatment methods. It can include approaches that target vascular endothelial growth factor (VEGFR) or rely on immune checkpoint inhibitors or mTOR inhibitors.

Clomiphene Citrate Treatment as an Alternative Therapeutic Approach for Male Hypogonadism: Mechanisms and Clinical Implications.

Male hypogonadism, which is characterized by low testosterone levels, has a significant impact on male sexual function, overall health, and fertility. Testosterone replacement therapy (TRT) is the conventional treatment for this condition, but it has potential adverse effects and is not suitable for men seeking to conceive. Testosterone plays an essential role in male sexual function, metabolism, mood, and overall well-being.

The Effectiveness and Safety of Wu Tou Decoction on Rheumatoid Arthritis-A Systematic Review and Meta-Analysis.

Rheumatoid arthritis (RA) is an autoimmune disease primarily affecting the joints and requires various treatments, including medication, injection, and physiotherapy. Wu tou decoction (WTD) is a traditional Chinese medicine prescribed for RA, with several articles documenting its effectiveness in RA treatment. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of WTD for RA.

The Effectiveness and Safety of Yi Shen Juan Bi Pill on Rheumatoid Arthritis: a Protocol for Systematic Review and/or Meta-Analysis.

Importance: The Yi Shen Juan Bi (YSJB) pill has been used to treat rheumatoid arthritis (RA), with several studies reporting its anti-inflammatory effects and ability to prevent bone destruction. However, the lack of evidence regarding the effectiveness and toxicity of individual components of YSJB limits its widespread use.

Objective: This protocol outlines a systematic review and/or meta-analysis to evaluate the effectiveness and safety of YSJB.

Healthcare Outcomes of Patients and Antecedents via Teleophthalmology in Eastern Taiwan during COVID-19.

Objective: The coronavirus disease 2019 (COVID-19) pandemic has caused significant transformations in healthcare. Many countries began the rapid development and adoption of telemedicine to avoid the spread of the pandemic and created an innovative model for healthcare delivery. This study identified the critical antecedents that affected the healthcare outcomes via in Eastern Taiwan during the COVID-19 pandemic.

Clustering broiler farmers based on their behavioural differences towards biosecurity to prevent highly pathogenic avian influenza.

Highly pathogenic avian influenza (HPAI) is an important zoonotic disease. The study aims to identify farmer behaviour types to inform the design of behaviour change programmes for mitigating the transmission of HPAI. Therefore, the study utilised multivariate statistical analysis for gaining a better understanding of the relationships among farmers' 30 biosecurity behaviours, the risk of HPAI infection, and distinct features of commercial broiler farmers, which is different from using simple and few binary biosecurity measures.

Multilevel Spontaneous Spinal Epidural Hematomas in a Recreational Weight Lifter.

Spontaneous spinal epidural hematoma (SSEH) is a nontraumatic condition that potentially compresses the spinal cord by accumulating blood in the epidural space. We report a case of multilevel SSEH in a 27-year-old male recreational weight lifter, presenting with acute lower back pain and bilateral leg weakness after deadlifts. Initial magnetic resonance imaging (MRI) showed subacute epidural hematomas with distinct signal intensities.