Publications by authors named "Sung Soo Ahn"
Background: Glioblastoma is the most aggressive adult primary brain cancer, characterized by significant heterogeneity, posing challenges for patient management, treatment planning, and clinical trial stratification.
Methods: We developed a highly reproducible, personalized prognostication and clinical subgrouping system using machine learning (ML) on routine clinical data, MRI, and molecular measures from 2,838 demographically diverse patients across 22 institutions and 3 continents. Patients were stratified into favorable, intermediate, and poor prognostic subgroups (I, II, III) using Kaplan-Meier analysis (Cox proportional model and hazard ratios [HR]).
Purpose: This study aimed to investigate whether the serum extracellular newly identified receptor for advanced glycation end products binding protein (EN-RAGE) and the soluble form of RAGE (sRAGE) measured at diagnosis are associated with all-cause mortality in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA).
Materials And Methods: Serum EN-RAGE and sRAGE were measured in 75 immunosuppressive drug-naïve MPA and GPA patients using an immunoassay, with their clinical and laboratory data reviewed. The optimal cut-off point of EN-RAGE and sRAGE was calculated by finding the threshold with the maximum sum of sensitivity and specificity.
Objectives: This study investigated whether serum syndecan1 at diagnosis reflects activity at diagnosis and predicts poor outcomes during follow-up in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
Methods: The study included 79 patients with AAV from the cohort of Korean patients diagnosed with AAV. AAV-specific indices, including the Birmingham vasculitis activity score (BVAS), five-factor score (FFS), 36-item short-form survey (SF-36) physical and mental component summary (PCS and MCS), and vasculitis damage index (VDI), were assessed.
: This study investigated whether serum alpha-1-acid glycoprotein (AGP) at diagnosis could reflect the cross-sectional activity represented by the Birmingham vasculitis activity score (BVAS) and further predict poor outcomes during follow-up in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). : This study included 70 patients with AAV. Clinical data at diagnosis, including AAV-specific indices and acute-phase reactants such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), were reviewed.
View Article and Find Full Text PDFAlthough gliomatosis cerebri (GC) has been removed as an independent tumor type from the WHO classification, its extensive infiltrative pattern may harbor a unique biological behavior. However, the clinical implication of GC in the context of the 2021 WHO classification is yet to be unveiled. This study investigated the incidence, clinicopathologic and imaging correlations, and prognostic implications of GC in adult-type diffuse glioma patients.
View Article and Find Full Text PDFPurpose: Whether molecular glioblastomas (GBMs) identify with a similar dismal prognosis as a "classical" histological GBM is controversial. This study aimed to compare the clinical, molecular, imaging, surgical factors, and prognosis between molecular GBMs and histological GBMs.
Methods: Retrospective chart and imaging review was performed in 983 IDH-wildtype GBM patients (52 molecular GBMs and 931 histological GBMs) from a single institution between 2005 and 2023.
Objectives: Recently, a joint group of the American College of Rheumatology (ACR) and the European Alliance of Associations for Rheumatology (EULAR) proposed new criteria for Takayasu arteritis (TAK) (the 2022 ACR/EULAR criteria). This study applied the 2022 ACR/EULAR criteria to patients with previously diagnosed TAK based on the 1990 ACR criteria and investigated the concordance rate between the two criteria according to the four imaging modalities.
Methods: This study reviewed the medical records of 179 patients who met the 1990 ACR criteria for TAK.
Purpose: To investigate whether qualitative and quantitative imaging phenotypes can predict the grade of oligodendroglioma.
Methods: Retrospective chart and imaging reviews were conducted on 180 adults with oligodendroglioma (IDH-mutant and 1p/19q codeleted) between 2005 and 2021. Qualitative imaging characteristics including tumor location, calcification, gliomatosis cerebri, cystic change, necrosis, and infiltrative pattern were analyzed.
Purpose: To investigate prognostic markers for H3 K27-altered diffuse midline gliomas (DMGs) in adults with clinical, qualitative and quantitative imaging phenotypes, including tumor oxygenation characteristics.
Methods: Retrospective chart and imaging reviews were conducted on 32 adults with H3 K27-altered DMGs between 2017 and 2023. Clinical and qualitative imaging characteristics were analyzed.
Objective: In this study, the association between the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) at diagnosis and poor outcomes of atherosclerosis-related antineutrophil cytoplasmic antibody-associated vasculitis (AAV) during follow-up in patients with AAV was investigated.
Methods: This retrospective study included 138 patients diagnosed with AAV. Their comprehensive medical records were meticulously reviewed.
Aims: The cerebellum is involved in higher-order mental processing as well as sensorimotor functions. Although structural abnormalities in the cerebellum have been demonstrated in schizophrenia, neuroimaging techniques are not yet applicable to identify them given the lack of biomarkers. We aimed to develop a robust diagnostic model for schizophrenia using radiomic features from T1-weighted magnetic resonance imaging (T1-MRI) of the cerebellum.
View Article and Find Full Text PDFArticle Synopsis
- Researchers developed a deep learning model to differentiate between glioblastoma and solitary brain metastasis using MRI, focusing on predictive uncertainty and interpretability.
- The model was trained on 469 patients and validated with another 143, achieving a high area under the curve (AUC) of 0.83 in the external test set, with better performance in low-uncertainty cases.
- The model showed strong reliability and robustness, indicating its potential for clinical use, particularly in accurately classifying uncertain cases.
Article Synopsis
- This study introduces a new way to classify patients with a type of brain cancer called IDH-wildtype glioblastomas by looking at how much of the tumor is removed during surgery.
- It involves 622 patients from one hospital and another 536 patients from three different hospitals, all of whom received standard cancer treatments and had tests to check their tumor characteristics.
- The new classification model shows that younger patients with certain tumor features have a better chance of living longer after surgery, compared to older patients or those with less successful surgeries.
Background: The incidence of leptomeningeal metastases (LM) has been reported diversely. This study aimed to investigate the incidence, risk factors, and prognosis of LM in patients with isocitrate dehydrogenase (IDH)-wildtype glioblastoma.
Methods: A total of 828 patients with IDH-wildtype glioblastoma were enrolled between 2005 and 2022.
Objectives: Tuberculosis is a highly contagious disease that has a significant impact on global health. Emerging evidence suggests that tuberculosis can lead to an altered immune response. We investigated the association between tuberculosis and the onset of inflammatory arthritides (IA).
View Article and Find Full Text PDFPurpose: There is lack of comprehensive analysis evaluating the impact of clinical, molecular, imaging, and surgical data on survival of patients with gliomatosis cerebri (GC). This study aimed to investigate prognostic factors of GC in adult-type diffuse glioma patients.
Methods: Retrospective chart and imaging review was performed in 99 GC patients from adult-type diffuse glioma (among 1,211 patients; 6 oligodendroglioma, 16 IDH-mutant astrocytoma, and 77 IDH-wildtype glioblastoma) from a single institution between 2005 and 2021.
Sex-Specific Differences in Patients with -Wild-Type Grade 4 Glioma in the ReSPOND Consortium.
AJNR Am J Neuroradiol
September 2024
Article Synopsis
- The study aimed to explore sex-based differences in patients with glioblastoma to enhance personalized treatment and improve outcomes, focusing on differences in tumor parameters and survival.
- Data from 1832 patients was analyzed, revealing that women were diagnosed at an older median age and had lower tumor volumes compared to men, who generally had higher performance scores.
- Despite these differences in tumor characteristics, the research found no significant discrepancies in survival outcomes or mortality rates between sexes, although certain factors like age and treatment type influenced mortality risk for both genders.
Purpose: Lower-grade gliomas of histologic grades 2 and 3 follow heterogenous clinical outcomes, which necessitates risk stratification. This study aimed to evaluate whether diffusion-weighted and perfusion-weighted MRI radiomics allow overall survival (OS) prediction in patients with lower-grade gliomas and investigate its prognostic value.
Materials And Methods: In this retrospective study, radiomic features were extracted from apparent diffusion coefficient, relative cerebral blood volume map, and Ktrans map in patients with pathologically confirmed lower-grade gliomas (January 2012-February 2019).
We evaluated chemokine expression and its correlation with disease activity in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) (MPA/GPA). Serum CCL2, CCL4, CCL19, CXCL1, CXCL2, and CX3CL1 level in 80 patients were analysed using multiple enzyme-linked immunosorbent assays. Correlations between variables were investigated using Pearson's correlation analysis, and receiver operator curve analysis was performed to identify optimal CX3CL1 values in determining active disease.
View Article and Find Full Text PDFArticle Synopsis
- Tuberculosis (TB) has a high global impact and is linked to increased risk of systemic vasculitides (SV), a type of autoimmune condition.
- A study using data from the South Korean National Claims database found that patients with TB had a significantly higher incidence of SV compared to controls, with specific risk levels being 1.72 times greater overall and 4.28 times greater for those with extrapulmonary TB.
- These results underline the importance of monitoring TB patients for early signs of SV to ensure timely treatment and management.
Article Synopsis
- A study was done to see if a deep learning system could help doctors find brain metastasis (cancer spread) better when using special black-blood imaging techniques.
- The system was tested on 365 patients, comparing how well four doctors could count and detect the brain tumors with and without the help of the deep learning tool.
- Results showed that the deep learning system made diagnosing brain metastasis more accurate and quicker, cutting the average reading time from about 67 seconds to 57 seconds.
Article Synopsis
- The study aims to compare midline-located IDH-wildtype glioblastomas (GBMs) and H3 K27-altered diffuse midline gliomas (DMGs) in adults by looking at clinical and imaging features, particularly tumor oxygenation.
- Analysis included preoperative MRI data from 55 patients, focusing on both qualitative and quantitative aspects such as tumor volume and oxygen extraction fraction (OEF), and logistic analyses were conducted to determine significant predictors.
- Key findings suggest younger age, specific tumor locations, and lower OEF are important imaging biomarkers that help differentiate H3 K27-altered DMGs from IDH-wildtype GBMs, with the potential to influence clinical practices.
Background/aims: This study applied the 2022 American College of Rheumatology (ACR)/European Alliance of Associations for Rheumatology (EULAR) criteria for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) to patients with systemic sclerosis (SSc) and investigated the frequency of overlap syndrome of SSc and AAV (SSc-AAV-OS).
Methods: Among the 232 patients diagnosed with SSc, 105 with signs suggestive of small- or medium-vessel vasculitis, which were defined as the present of interstitial lung disease (ILD), peripheral neuropathy, or suspected renal vasculitis, were included in this study and analyzed.
Results: Among the 105 SSc patients, the detection rate of ANCA was 19.