Background: Acute hyperglycemia frequently occurs in stressful situations, including liver transplantation or hepatic surgery, which may affect the protective effects of dexmedetomidine preconditioning and increase postoperative mortality. Therefore, this study aimed to investigate the effects of dexmedetomidine on hepatic ischemia-reperfusion injury in acute hyperglycemia.
Methods: Thirty-six Sprague-Dawley rats were randomly assigned to 6 groups, including a combination between 2 glycemic (normo- and hyperglycemia) and 3 ischemia-reperfusion conditions (sham, ischemia-reperfusion only, and dexmedetomidine plus ischemia-reperfusion).
Annual coffee consumption has increased to 10 million tons. Of the coffee consumed, 65% is discarded as spent coffee grounds (SCG). However, most SCG are buried in the ground as organic waste.
View Article and Find Full Text PDFThe adoption of artificial intelligence in post-earthquake inspections and reconnaissance has received considerable attention in recent years, owing to its exponential increase in computation capabilities and inherent potential in addressing disadvantages associated with manual inspections. Herein, we present the effectiveness of automated deep learning in enhancing the assessment of damage caused by the 2017 Pohang earthquake. Six classical pre-trained convolutional neural network (CNN) models are implemented through transfer learning (TL) on a small dataset, comprising 1780 manually labeled images of structural damage.
View Article and Find Full Text PDFThe use of nontraditional soil stabilizers increases. Various new soil binding agents are under study to augment renewability and sustainability of an earth structure. However, despite increasing interest involved in red clay, there is minimal research investigating the stabilizing red clay with polymer.
View Article and Find Full Text PDFBackground: Dexmedetomidine is known to protect against ischemia-reperfusion (IR) in various organs; however, the mechanisms of dexmedetomidine in the liver remain unclear. We investigated whether dexmedetomidine preconditioning leads to hepatic protection and whether nitric oxide was associated with this protective mechanism by employing N-nitro-l-arginine methyl ester (l-NAME), a nitrous oxide synthase inhibitor.
Methods: Experiment 1 included 24 rats in 4 groups: sham, IR, 30 μg/kg of dexmedetomidine, and 50 μg/kg of dexmedetomidine.
The shear and particle crushing characteristics of the failure plane (or shear surface) in catastrophic mass movements are examined with a ring shear apparatus, which is generally employed owing to its suitability for large deformations. Based on results of previous experiments on waste materials from abandoned mine deposits, we employed a simple numerical model based on ring shear testing using the particle flow code (PFC). We examined drainage, normal stress, and shear velocity dependent shear characteristics of landslide materials.
View Article and Find Full Text PDFBackground: Anxiolytic premedication requires careful consideration owing to potential side effects including delayed recovery after ambulatory anesthesia. We aimed to compare the effect of midazolam on recovery profiles postoperatively, depending on whether propofol or sevoflurane was the primary anesthetic.
Methods: We enrolled 226 patients (age, 18-50 years) undergoing ambulatory gynecologic laparoscopic surgery.
Titanium dioxide (TiO), the golden standard among the photocatalysts, exhibits a varying level of photocatalytic activities (PCA) amongst the synthetically prepared and commercially available products. For commercial applications, superior photoactivity and cost-effectiveness are the two main factors to be reckoned with. This study presents the development of simple, cost-effective post-treatment processes for a less costly TiO to significantly enhance the PCA to the level of expensive commercial TiO having demonstrated superior photoactivities.
View Article and Find Full Text PDFHerein, we suggest a wire mesh method to classify the particle shape of large amounts of aggregate. This method is controlled by the tilting angle and opening size of the wire mesh. The more rounded the aggregate particles, the more they roll on the tilted wire mesh.
View Article and Find Full Text PDFCasein is often used as an eco-friendly wood adhesive. In this study, we used casein for soil cementation by mixing it with Jumunjin sand, sodium hydroxide (SH), and calcium hydroxide (CH) as a standard casein formula. The modified casein binder with different proportions of SH and CH was applied to improve water resistance.
View Article and Find Full Text PDFAlthough remote ischemic preconditioning (RIPC) is an organ-protective maneuver from subsequent ischemia reperfusion injury (IRI) by application of brief ischemia and reperfusion to other organs, its mechanism remains unclear. However, it is known that RIPC reduces the heart, brain, and liver IRI, and that nitric oxide (NO) is involved in the mechanism of this effect. To identify the role of NO in the protective effect of RIPC in renal IRI, this study examined renal function, oxidative status, and histopathological changes using N-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor.
View Article and Find Full Text PDFPurpose: Hydrogen sulfide (H₂S) is an endogenous gaseous molecule with important physiological roles. It is synthesized from cysteine by cystathionine γ-lyase (CGL) and cystathionine β-synthase (CBS). The present study examined the benefits of exogenous H₂S on renal ischemia reperfusion (IR) injury, as well as the effects of CGL or CBS inhibition.
View Article and Find Full Text PDFNeuroinflammation is implicated for dopaminergic neurodegeneration. Sulfur compounds extracted from garlic have been shown to have anti-inflammatory properties. Previously, we have investigated that thiacremonone, a sulfur compound isolated from garlic has anti-inflammatory effects on several inflammatory disease models.
View Article and Find Full Text PDFBackground: Caudal block is a popular regional anesthesia in children undergoing infraumbilical surgeries including inguinal hernia repair and orchiopexy. We evaluated the efficacy of eutectic mixture of local anesthetic (EMLA) cream for reducing needle insertion pain during caudal block in pediatric patients.
Methods: Forty-one children between the ages of 13 months and 5 years undergoing infraumbilical surgery were randomized to receive either topical EMLA or placebo cream over the sacral hiatus one hour before caudal block.
Introduction: We examined the activity of mitogen-activated protein kinase (MAPK) family members, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38, in rats pinal cord after hind limb ischemia reperfusion (IR) and analyzed the role of reactive oxygen species (ROS) as mediators of MAPK signaling under these conditions.
Methods: In experiment 1, hind limb IR rats were treated intraperitoneally with one of following agents at 30 min before reperfusion: allopurinol (4, 40 mg/kg), superoxide dismutase (SOD, 4000 U/kg), N-nitro-l-arginine methyl ester (l-NAME, 10 mg/kg), or SOD (4000 U/kg) + l-NAME (10 mg/kg). In experiment 2, 5,10,15,20-tetrakis (N-methyl-4'-pyridyl) porphyrinato iron (III) (FeTMPyP) was administered intraperitoneally (1, 3, or 10 mg/kg) 30 min before reperfusion.
The contributions of superoxide and nitric oxide to ischemia/reperfusion (I/R)-induced neuropathic pain have previously been demonstrated in an animal model that mimics the symptoms of complex regional pain syndrome type I (CRPS I). Targeting peroxynitrite, which is the product of their interaction, may provide effective treatments for I/R-induced neuropathic pain. In this study, the effect of the peroxynitrite decomposition catalyst FeTMPyP [5,10,15,20-tetrakis (N-methyl-4'-pyridyl)porphyrinato iron (III)], administered at doses of 1, 3 and 10 mg/kg via intraperitoneal injection 30 min prior to reperfusion, was evaluated in rats with chronic post-ischemic pain.
View Article and Find Full Text PDFPurpose: Endoscopic submucosal dissection has recently been practiced on a differentiated type of early gastric cancer. However, there is no clear evidence for endoscopic treatments of signet ring cell carcinoma. The aim of this study is to identify the predictive clinicopathological factors for lymph node metastasis in signet ring cell carcinoma for assisting endoscopic submucosal dissection trials.
View Article and Find Full Text PDFBackground: Reactive oxygen species and inflammatory responses contribute to the development of neuropathic pain. Superoxide serves to mediate cell signaling processes and tissue injury during inflammation. We examined the effects of superoxide on the development and maintenance of mechanical allodynia, as well as its contribution to central sensitization in a superoxide-rich animal model of neuropathic pain.
View Article and Find Full Text PDFDuring the prostate cancer (PCa) development and its progression into hormone independency, androgen receptor (AR) signals play a central role by triggering the regulation of target genes, including prostate-specific antigen. However, the regulation of these AR-mediated target genes is not fully understood. We have previously demonstrated a unique role of HOXB13 homeodomain protein as an AR repressor.
View Article and Find Full Text PDFBackground: Withdrawal movement during rocuronium injection is a common, unresolved adverse effect. We aimed to investigate the effect of IV acetaminophen pretreatment on withdrawal movement during rocuronium injection.
Methods: This study enrolled 120 American Society of Anesthesiologists (ASA) I-II patients undergoing general anesthesia.
Korean J Anesthesiol
October 2009
Background: Endotracheal tube extubation can cause laryngospasm, aspiration, upper airway obstruction and hypoxia. In addition, the risk of pulmonary complication increases during extubation for the patients with a difficult airway or a cervical spine injury. The aim of this study was to exam the effect of continuous positive airway pressure (CPAP) on the post-extubation airway patency and the recovery from anesthesia at the recovery room.
View Article and Find Full Text PDFThe relationship between the interstitial cells of Cajal (ICC) and enteric nerves or smooth muscles cells is not fully defined. Presently, distribution and appearance of ICC in the rat stomach and duodenum was studied by immunohistochemistry, electron microscopy, and three-dimensional reconstruction. c-kit expressing ICC were regularly observed in the Auerbach's myenteric plexus (AP) of the stomach and duodenum.
View Article and Find Full Text PDFBackground: Mirror-image allodynia is a mysterious phenomenon that occurs in association with many clinical pain syndromes including complex regional pain syndromes (CRPS). Underlying mechanisms for the development of such pain are still a matter of investigation. Several studies suggest that activation of the N-methyl-D-aspartate (NMDA) receptor is essential for central sensitization as a base for persistent pain.
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