MMP expression profiling in recurred stage IB lung cancer.

We aimed to clarify the prime role of recurrence in stage I lung cancer. To determine the expression profiles, quantitative RT-PCR and real-time PCR were performed subsequently to evaluate the validity of meaningful molecules identified by 0.12 K c-DNA array experiment surveys.

Increased expression of matrix metalloproteinase 9 correlates with poor prognostic variables in renal cell carcinoma.

Background: MMP2 and MMP9 are two gelatinolytic enzymes, which are key regulators of tumor invasion and metastasis. This study aimed to clarify the prognostic significance of MMP2 and MMP9 with particular regard to their transcript levels, enzymatic activities in renal cell carcinomas (RCCs).

Materials And Methods: Through cDNA array, the differential expression of the MMP superfamily was evaluated in RCC.