Large-Scale Fabrication of Copper-Ion-Coated Deoxyribonucleic Acid Hybrid Fibers by Ion Exchange and Self-Metallization.

It has been a challenge to achieve deoxyribonucleic acid (DNA) metallization and mass production with a high quality. The main aim of this study was to develop a large-scale production method of metal-ion-coated DNA hybrid fibers, which can be useful for the development of physical devices and sensors. Cetyltrimethylammonium-chloride-modified DNA molecules (CDNA) coated with metal ions through self-metallization exhibit enhanced optical and magnetic properties and thermal stability.

DNA Multilayers with Mono-, Hetero-, and Mixed-Type Plasmonic Nanoparticles for Broadband Absorption and Energy Storage.

DNA incorporated with functional materials has led to development of hybrids with different functionalities. Among the functional materials, metal nanoparticles such as Au, Ag, and Cu (also known as plasmonic nanoparticles [PNPs]), which can exhibit surface plasmon resonance, are good candidates to fabricate useful optoelectronic devices and sensors. Here, we constructed PNP-assorted DNA (PNP-DNA) layers with mono-, hetero-, and mixed-type PNPs formed by successive spin-coating to obtain the required number of layers.

Language-Related White-Matter-Tract Deficits in Children with Benign Epilepsy with Centrotemporal Spikes: A Retrospective Study.

Background And Purpose: Benign epilepsy with centrotemporal spikes (BECTS) is one of the most common pediatric epilepsies, and it generally has a good prognosis. However, recent research has indicated that the epileptic activity of BECTS can cause cognitive defects such as language, visuospatial, and auditory verbal memory deficits. This study assessed language-delivery deficits in BECTS patients using diffusion-tensor magnetic resonance imaging (DTI).

White light emission produced by CTMA-DNA nanolayers embedded with a mixture of organic light-emitting molecules.

Researchers have started to recognize that biomaterial-based devices and sensors can be used in the development of high-performing environmentally-friendly technologies. In this regard, DNA can be utilized as a competent scaffold for hosting functional nanomaterials to develop a designated platform in the field of bionanotechnology. Here, we introduce a novel methodology to construct CTMA-modified DNA nanolayers (CDNA NLs) embedded with single (, red, green, and blue), double (violet, yellow, and orange), and triple (white) iridium-based organic light-emitting materials (OLEMs, including Ir(piq)(acac) for red, Ir(ppy)(acac) for green, FIrpic for blue) that can serve as active light-emitting layers.

Machine learning based risk prediction model for asymptomatic individuals who underwent coronary artery calcium score: Comparison with traditional risk prediction approaches.

Background: Machine learning (ML) is a computer algorithm used to identify patterns for prediction in various tasks, and ML methods have been beneficial for developing prediction models when applied to heterogeneous and large datasets. We aim to examine the prognostic ability of a ML-based prediction algorithm utilizing routine health checkup data to predict all-cause mortality (ACM) compared to established risk prediction approaches.

Methods: A total 86155 patients with seventy available parameters (35 clinical, 32 laboratory, and 3 coronary artery calcium score [CACS] parameters) were analyzed.

One-Pot Exfoliation of Graphitic C N Quantum Dots for Blue QLEDs by Methylamine Intercalation.

Here, a simplified synthesis of graphitic carbon nitride quantum dots (g-C N -QDs) with improved solution and electroluminescent properties using a one-pot methylamine intercalation-stripping method (OMIM) to hydrothermally exfoliate QDs from bulk graphitic carbon nitride (g-C N ) is presented. The quantum dots synthesized by this method retain the blue photoluminescence with extremely high fluorescent quantum yield (47.0%).

A Neuromorphic Device Implemented on a Salmon-DNA Electrolyte and its Application to Artificial Neural Networks.

A bioinspired neuromorphic device operating as synapse and neuron simultaneously, which is fabricated on an electrolyte based on Cu-doped salmon deoxyribonucleic acid (S-DNA) is reported. Owing to the slow Cu diffusion through the base pairing sites in the S-DNA electrolyte, the synaptic operation of the S-DNA device features special long-term plasticity with negative and positive nonlinearity values for potentiation and depression (α and α), respectively, which consequently improves the learning/recognition efficiency of S-DNA-based neural networks. Furthermore, the representative neuronal operation, "integrate-and-fire," is successfully emulated in this device by adjusting the duration time of the input voltage stimulus.

Metal and Lanthanide Ion-Co-doped Synthetic and Salmon DNA Thin Films.

Researchers have begun to use DNA molecules as an efficient template for arrangement of multiple functionalized nanomaterials for specific target applications. In this research, we demonstrated a simple process to co-dope synthetic DNA nanostructures (by a substrate-assisted growth method) and natural salmon DNA thin films (by a drop-casting method) with divalent metal ions (M, e.g.

High tumoral PD-L1 expression and low PD-1 or CD8 tumor-infiltrating lymphocytes are predictive of a poor prognosis in primary diffuse large B-cell lymphoma of the central nervous system.

We investigated the clinicopathological role of the PD-1/PD-L1 pathway in primary diffuse large B-cell lymphoma of the central nervous system (PCNS-DLBCL) arising in the immune-privileged site. PD-L1 immunostaining of ≥30% of tumor cells was defined as tPD-L1+, and PD-L1 immunostaining of ≥30% of total cellularity, including tumor and non-tumoral cells, as tmPD-L1+ . PD-1 and CD8 tumor-infiltrating lymphocytes (TILs) were enumerated.

IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation.

Activation of macrophage proinflammatory and antimicrobial phenotypes is regulated by IFN-γ and LPS via synergistic induction of canonical, inflammatory NF-κB target genes. However, whether IFN-γ negatively regulates components of the LPS response, and how this may affect macrophage activation, is still unclear. Here we use combined transcriptomic and epigenomic approaches to find that IFN-γ selectively abrogates LPS-induced feedback and alters macrophage metabolic pathways by suppressing TLR4-mediated gene activation.

The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.

Cytokine tumor necrosis factor (TNF)-mediated macrophage polarization is important for inflammatory disease pathogenesis, but the mechanisms regulating polarization are not clear. We performed transcriptomic and epigenomic analysis of the TNF response in primary human macrophages and revealed late-phase activation of SREBP2, the master regulator of cholesterol biosynthesis genes. TNF stimulation extended the genomic profile of SREBP2 occupancy to include binding to and activation of inflammatory and interferon response genes independently of its functions in sterol metabolism.

Infrared excited Er/Yb codoped NaLaMgWO phosphors with intense green up-conversion luminescence and excellent temperature sensing performance.

The Er/Yb-codoped NaLaMgWO phosphors were synthesized via a traditional high-temperature solid-state reaction method. The temperature sensing performance was thoroughly investigated by studying the temperature-dependent up-conversion (UC) emission intensity ratio in the range of 293-533 K. A remarkable enhancement of green UC emission, as well as enhanced temperature sensitivity, were observed by increasing the Yb concentration.

Prognostic Impact of Extended Lymph Node Dissection versus Limited Lymph Node Dissection on pN0 Proximal Advanced Gastric Cancer: a Propensity Score Matching Analysis.

Purpose: Splenic hilar lymph node dissection (LND) during total gastrectomy is regarded as the standard treatment for proximal advanced gastric cancer (AGC). This study aimed to investigate whether splenic hilar LND or D2 LND is essential for proximal AGC of pT2-4aN0M0 stage.

Materials And Methods: Data of curative total gastrectomies (n=370) performed from 2000 to 2010 for proximal AGC of pT2-4aN0 stage were retrospectively reviewed.

A Bcr-Abl Inhibitor GNF-2 Attenuates Inflammatory Activation of Glia and Chronic Pain.

GNF-2 is an allosteric inhibitor of Bcr-Abl. It was developed as a new class of anti-cancer drug to treat resistant chronic myelogenous leukemia. Recent studies suggest that c-Abl inhibition would provide a neuroprotective effect in animal models of Parkinson's disease as well as in clinical trials.

A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy.

Patient-specific ex vivo models of human tumours that recapitulate the pathological characteristics and complex ecology of native tumours could help determine the most appropriate cancer treatment for individual patients. Here, we show that bioprinted reconstituted glioblastoma tumours consisting of patient-derived tumour cells, vascular endothelial cells and decellularized extracellular matrix from brain tissue in a compartmentalized cancer-stroma concentric-ring structure that sustains a radial oxygen gradient, recapitulate the structural, biochemical and biophysical properties of the native tumours. We also show that the glioblastoma-on-a-chip reproduces clinically observed patient-specific resistances to treatment with concurrent chemoradiation and temozolomide, and that the model can be used to determine drug combinations associated with superior tumour killing.

Idiopathic Granulomatous Hypophysitis with Rapid Onset: A Case Report.

Idiopathic granulomatous hypophysitis (IGH), a rare disease, requires differentiation from more common mass lesions of the sella such as pituitary adenoma, craniopharyngioma, Rathke's cleft cyst, or pituitary tuberculoma. IGH usually presents with an insidious onset of visual defects and headaches. On the other hand, rapid onset of neurologic and visual symptoms in an IGH patient is exceptionally rare.

The observation of resistive switching characteristics using transparent and biocompatible Cu-doped salmon DNA composite thin film.

For the potential switching bio-memory device application using DNA composite thin film, we fabricated and characterized the transparent and biocompatible resistive switching random access memory (RRAM) device within the structure stacking of Pt/Cu doped salmon DNA/FTO, where Cu doping into salmon DNA was solution-processed. The device shows good bipolar switching characteristics with SET and RESET processes at negative and positive sweeps, respectively, with switching memory window greater than 10 ratios. The device was observed to be in low resistance state as its pristine state and an initial RESET state was necessary to achieve programmable SET and RESET cycles.

Graphene oxide induces cardiovascular defects in developing zebrafish (Danio rerio) embryo model: In-vivo toxicity assessment.

Graphene oxide (GO) has wide engineering applications in various areas, including electronics, energy storage, pharmaceuticals, nanomedicine, environmental remediation and biotechnology, because of its unique physico-chemical properties. In the present study, the risk-related information of GO was evaluated to examine the potential ecological and health risks of developmental toxicity. Although the overall developmental toxicity of GO has been well characterized in zebrafish, however, its release effect at a certain concentration of living organisms with specific cardiovascular defects remains largely elusive.

Hierarchical multi-level block copolymer patterns by multiple self-assembly.

Uniform, well-ordered sub-20 nm patterns can be generated by the templated self-assembly of block copolymers (BCPs) with a high Flory-Huggins interaction parameter (χ). However, the self-assembled BCP monolayers remain limited in the possible structural geometries. Here, we introduce a multiple self-assembly method which uses di-BCPs to produce diverse morphologies, such as dot, dot-in-honeycomb, line-on-dot, double-dot, pondering, dot-in-pondering, and line-on-pondering patterns.

Late Recurrence of Wilms Tumor After 17 Years: A Case Report.

Wilms tumor is the most common renal malignancy in children. Most of Wilms tumor recurrences occur within 2 years of the first diagnosis. Relapse after 5 years after the first diagnosis is called "late recurrence" and is rare in Wilms tumor.

Clinical Characteristics of Acute Appendicitis in Kidney Transplant Recipients.

BACKGROUND Clinical characteristics of acute appendicitis in kidney transplant recipients may be different from those in the general population due to kidney transplant recipient's immunosuppressive state and position change of appendix caused by graft. MATERIAL AND METHODS Clinical characteristics of 10 cases of acute appendicitis among 2880 cases of kidney transplantation were evaluated, including diagnostic rate, location of appendix and complication in kidney transplant recipients. RESULTS Acute appendicitis was suspected in 9 of 10 patients (90%) with acute appendicitis based on clinical and laboratory findings.

Variation in the Height of Rectal Cancers According to the Diagnostic Modalities.

Purpose: Although the height of a rectal tumor above the anal verge (tumor height) partly determines the treatment strategy, no practical standard exists for reporting this. We aimed to demonstrate the differences in tumor height according to the diagnostic modality used for its measurement.

Methods: We identified 100 patients with rectal cancers located within 15 cm of the anal verge who had recorded tumor heights measured by using magnetic resonance imaging (MRI), colonoscopy, and digital rectal examination (DRE).

Effects of Tocilizumab Therapy on Serum Interleukin-33 and Interleukin-6 Levels in Patients With Rheumatoid Arthritis.

Objectives: This study aims to examine the effects of tocilizumab therapy on serum levels of interleukin (IL)-33 and IL-6 in rheumatoid arthritis (RA) patients.

Patients And Methods: Interleukin-33 and IL-6 levels in serum samples from 83 RA patients (10 males, 73 females; mean age 51.9 years; range, 26 to 77 years) and 12 healthy controls (2 males, 10 females; mean age 52.

Er-Activated NaLaMgWO double perovskite phosphors and their bifunctional application in solid-state lighting and non-contact optical thermometry.

Herein, Er3+-activated NaLaMgWO6 phosphors were prepared by a traditional high-temperature solid-state method. Based on the double perovskite structure of the NaLaMgWO6 host, we observe the desirable PL properties of Er3+. When excited at about 378 nm, the as-obtained materials can emit strong green light.

Simultaneous bifunctional application of solid-state lighting and ratiometric optical thermometer based on double perovskite LiLaMgWO:Er thermochromic phosphors.

Realization of simultaneous, efficient bifunctional application of thermochromic phosphors on light emitting diodes (LEDs) and as ratiometric thermometers is significant. Herein, doped Er ions are introduced as an activator into double perovskite LiLaMgWO host lattice. The developed phosphors can be efficiently excited by a near-ultraviolet LED chip and show bright green emission, mainly at 527 and 543 nm, as well as very low thermal quenching.