Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population.

Background: The effect of vitamin D on allergic conditions is unclear. In particular, large-scale, population-based studies examining this relationship in adult Asian populations are lacking.

Objective: To evaluate the association between serum vitamin D levels and allergic conditions in the general adult Korean population.

Incidence of primary skin cancer after organ transplantation: An 18-year single-center experience in Korea.

Background: Skin cancer is the most common malignancy to arise after organ transplantation in Caucasians, but limited data are available on its incidence in Asian transplant recipients.

Objective: We sought to assess the incidence of skin cancer after organ transplantation in a Korean cohort.

Methods: A cohort study was conducted to determine the incidence and risk factors for skin cancers among kidney, liver, heart, or pancreas transplant recipients, treated at the Asan Medical Center in Seoul, Korea.

Precursor B- or T-lymphoblastic lymphoma presenting with cutaneous involvement: a series of 13 cases including 7 cases of cutaneous T-lymphoblastic lymphoma.

Background: Lymphoblastic lymphoma (LBL) is a rare neoplasm of precursor lymphocytes, and cutaneous involvement is present in less than 20% of cases.

Objective: We sought to describe the clinical and histopathological features of cutaneous LBL.

Methods: We retrospectively examined the clinical and histologic features of 13 patients with cutaneous LBL, 6 with B-LBL and 7 with T-LBL.

Comparison of microneedle fractional radiofrequency therapy with intradermal botulinum toxin a injection for periorbital rejuvenation.

Background: For periorbital rejuvenation, injection of botulinum toxin A (BoNT/A) is known to improve both static as well as dynamic wrinkles. A microneedle fractional radiofrequency (MFR) device was recently developed and is a novel and promising tool.

Objective: This study compares the effects of these two treatment modalities on periorbital static wrinkles and lines.

Epidermal growth factor and epidermal growth factor signaling attenuate laser-induced melanogenesis.

Background: Epidermal growth factor (EGF) is a peptide that promotes cell growth by binding to its receptor (EGFR) on the cell surface. EGF has been used in cosmetics to whiten the skin and for the prevention of postinflammatory hyperpigmentation (PIH), presumably by accelerating wound healing, but the effects of EGF on melanogenesis are not known, and the presence of EGFR on melanocytes has not been confirmed.

Methods: To establish a role of EGF in melanogenesis, we first investigated expression of EGFR on melanocytes.

Efficacy and safety of a new monophasic hyaluronic acid filler in the correction of nasolabial folds: a randomized, evaluator-blinded, split-face study.

Background: Hyaluronic acid (HA) fillers are frequently used for the correction of facial soft-tissue defects.

Objective: To compare the efficacy and safety of a novel monophasic HA filler (mono-HA), and a well-studied biphasic HA filler (bi-HA), in the treatment of moderate to severe nasolabial folds.

Methods: In this randomized, evaluator-blinded, split-face comparative study, subjects were randomized for injections with mono-HA or bi-HA on the left or right side of the face.

Clinical efficacy of the dual-pulsed Q-switched neodymium:yttrium-aluminum-garnet laser: Comparison with conservative mode.

The quality (Q)-switched neodymium:yttrium-aluminum-garnet (Nd:YAG) laser is one of the first non-ablative lasers to be used for facial resurfacing and photorejuvenation. Recently, the method of low-fluence Q-switched Nd:YAG lasers known as 'laser toning' has been used for non-ablative skin rejuvenation and for the treatment of melasma in Asian countries. We report our experience of using a novel Q-switched Nd:YAG laser that was operated as a dual pulse at half fluence and 140-μs intervals compared with conservative mode laser.

RimabotulinumtoxinB versus OnabotulinumtoxinA in the treatment of masseter hypertrophy: a 24-week double-blind randomized split-face study.

Background: Masseter hypertrophy can be ameliorated by botulinum toxin.

Objective: To compare the efficacy and safety of RimabotulinumtoxinB (BTX-B) and OnabotulinumtoxinA (BTX-A) in the treatment of masseter hypertrophy.

Methods: Sixteen women with bilateral masseter hypertrophy received single injections of BTX-A or BTX-B at a dose ratio of 1:50 or 1:70 in a 24-week double-blind randomized split-face study.

A child with interstitial granulomatous dermatitis and juvenile idiopathic arthritis.

We describe a case of interstitial granulomatous dermatitis (IGD) with juvenile idiopathic arthritis (JIA) in an 11-year-old girl. She complained of erythematous plaques on her thighs and polyarthritis for 1 year. Histopathologic examination revealed the features of IGD.

Formation of new melasma lesions in the periorbital area following high-fluence, 1064-nm, Q-switched Nd/YAG laser.

Although ultraviolet (UV) light or exogenous hormones have been associated with the development or exacerbation of melasma, the use of laser as a treatment modality has not been cited as a factor linked to the development of melasma lesions. It is unclear whether epidermal trauma caused by laser or other treatment can lead to the formation of a new melasma lesion. We report on the formation of new melasma lesions in a patient who was treated for acquired bilateral nevus of Ota-like macules (ABNOM) with a high-fluence 1064 nm Q-switched (QS) neodymium-doped yttrium aluminum garnet (Nd/YAG) laser.

Adverse events of non-ablative fractional laser photothermolysis: a retrospective study of 856 treatments in 362 patients.

Background: Non-ablative fractional laser photothermolysis (NAFP) has been used effectively in the treatment of photodamaged skin and scars, with short post-operative recovery times; but, studies evaluating its adverse events and complication rates in Asian population have been limited.

Objective: To determine the frequency and range of adverse events associated with NAFP treatment in Korean patients.

Materials And Methods: We retrospectively evaluated the outcomes of 754 1550-nm erbium-doped and 102 1927-nm thulium fiber fractional laser treatments in patients with skin phototypes III-IV treated at a single center.

The first documented case of true botulinum toxin granuloma.

We report a unique case of foreign-body granuloma following botulinum neurotoxin type A (BoNTA) injection. A 44-year-old woman was injected with BoNTA by a dermatologist. Within 2 months of treatment, palpable nodules developed on injection site and biopsy revealed foreign-body granuloma.

Adverse events associated with botulinum toxin injection: a multidepartment, retrospective study of 5310 treatments administered to 1819 patients.

Background: The injection of botulinum toxin is now commonly used for many therapeutic and cosmetic purposes but because of its increased use more adverse events are being reported.

Objective: To retrospectively evaluate and analyze the safety of botulinum toxin injections in terms of purpose and the type of toxin administered.

Materials And Methods: Data were collected on 1819 patients who underwent a total of 5310 treatments between 2005 and 2011 at a single tertiary medical center.

Split-face study using a 1,927-nm thulium fiber fractional laser to treat photoaging and melasma in Asian skin.

Background: Although the 1,927-nm thulium fiber fractional laser is effective and safe for treating photoaging, clinical data regarding this modality remain limited.

Objective: To investigate the efficacy and safety of the 1,927-nm thulium fiber fractional laser for treating photoaging and melasma in Asians.

Methods: Twenty-five participants received three laser treatments (at 3-week intervals) on the half of the face with more-severe photoaging and melasma.

Coexistence of congenital giant melanocytic nevus of the scalp with cranial defect, poliosis, and hair loss.

Congenital melanocytic nevi (CMN) are pigmented lesions presenting on the skin in approximately 1% of all newborns at or shortly after birth. CMN have been described as being associated with several anomalies, including cranial bone hypertrophy, scoliosis, and spina bifida. This is the first report to describe a giant congenital melanocytic nevus on the scalp associated with cranial involvement, poliosis, and alopecia.

Knockdown of β-catenin controls both apoptotic and autophagic cell death through LKB1/AMPK signaling in head and neck squamous cell carcinoma cell lines.

The Wnt/β-catenin pathway regulates the viability and radiosensitivity of head and neck squamous cancer cells (HNSCC). Increased β-catenin predisposes HNSCC patients to poor prognosis and survival. This study was conducted to determine the mechanism by which β-catenin regulates the viability of HNSCC.

Fractionated microneedle radiofrequency for the treatment of periorbital wrinkles.

Non-ablative bipolar and monopolar radiofrequency devices have been shown to be effective for the treatment of facial wrinkles. Recently, novel fractionated microneedle radiofrequency (FMRF) devices have been introduced. The aim of this study was to evaluate the clinical effectiveness and safety of FMRF for the treatment of periorbital wrinkles.

A wedge-shaped anterior hairline extension associated with a tessier number 10 cleft.

A wedge-shaped anterior hairline extension is a very rare skin manifestation usually associated with congenital anomalies including a Tessier number 10 cleft. Other associated conditions are the Tessier number 9 cleft, the Fraser syndrome, and the Manitoba oculotrichoanal syndrome (MOTA syndrome). The Tessier number 10 cleft features include a coloboma of the middle third of the upper eyelid, and an eyebrow divided into two portions.

A fractional 2940 nm short-pulsed, erbium-doped yttrium aluminium garnet laser is effective and minimally invasive for the treatment of photodamaged skin in Asians.

Background: Although ablative fractional laser for the facial photodamaged skin was effective and safe, there have been only limited reports regarding the efficacy and safety of fractional Er:YAG laser treatments for photodamaged facial skin in Asians.

Objective: Our objective was to assess the efficacy and safety of the Er:YAG laser (2940 nm) using the ''ablative'' fractional resurfacing mode to treat photodamaged facial skin.

Methods: A total of 29 Korean patients were treated for photodamaged facial skin using a fractional Er:YAG laser.

Long-pulsed Nd:YAG laser on periorbital wrinkles in Asian patients: randomized split face study.

Background And Objective: This study evaluated clinical usefulness of long-pulsed Nd:YAG laser (LPNY) for periorbital wrinkles in Asian patients.

Methods: Twenty seven Korean patients were treated with several passes of LPNY (5 mm spot size, fluence: 54.7-61.