Publications by authors named "Sung Been Lim"
We synthesized a series of amphiphilic cationic poly(ethylene glycol)--poly(β-amino acid) derivatives with various lengths of PEG to investigate the effects of PEG lengths on mRNA transfection. The surface charges of the polyplexes with a DP ≥ 4 gradually decreased as DP increased. This indicated that hydrophilic PEG with a DP ≥ 4 was exposed on the surface of the polyplexes, which was further confirmed using H NMR.
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- * The review highlights the mechanisms of how polymer-nucleic acid complexes (polyplexes) escape endosomes, emphasizing the importance of the acid dissociation constant (pK) in creating these polymers.
- * Machine learning is also discussed as a tool for predicting pK values and aiding in the design of innovative pH-responsive polymers for improved nucleic acid delivery.