[Not Available].

This review aims at RCT's of psychedelics used in the treatment of depression and PTSD. Psilocybin has shown an antidepressant effect in cancer patients that was sustained at 6- and 12-months follow-up. The effect of psilocybin was comparable to escitalopram in one study.

Peripheral artery disease in patients with schizophrenia as compared to controls.

Background: Patients with schizophrenia have an increased prevalence of risk factors for peripheral artery disease (PAD) and is expected to have an increased prevalence of PAD. PAD can be detected utilizing toe-brachial index (TBI) which screens for vascular pathology proximal to the toes.

Methods: Using a cross-sectional design, we defined the subpopulations: (1) Patients diagnosed with schizophrenia less than 2 years before inclusion (SCZ < 2), (2) Psychiatric healthy controls matched to subpopulation 1 on sex, age, and smoking status, and (3) Patients diagnosed with schizophrenia 10 or more years before inclusion (SCZ ≥ 10).

Lithium induced hypercalcemia: an expert opinion and management algorithm.

Background: Lithium is the gold standard prophylactic treatment for bipolar disorder. Most clinical practice guidelines recommend regular calcium assessments as part of monitoring lithium treatment, but easy-to-implement specific management strategies in the event of abnormal calcium levels are lacking.

Methods: Based on a narrative review of the effects of lithium on calcium and parathyroid hormone (PTH) homeostasis and its clinical implications, experts developed a step-by-step algorithm to guide the initial management of emergent hypercalcemia during lithium treatment.

Bipolar disorder and regretted behavior in relation to use of social media and online dating.

Objectives: Individuals with bipolar disorder are prone to risk-taking behavior that is subsequently regretted. Here, we investigated whether this also occurs in relation to the use of social media and online dating.

Methods: A questionnaire-based survey focusing on the use of social media and online dating was conducted among individuals attending an outpatient clinic for bipolar disorder, and among individuals attending two general practices in the same region (controls).

[Management of antipsychotic-induced metabolic side effects].

Antipsychotics are associated with significant weight gain and other metabolic side effects. There are, however, substantial differences in their propensity for causing metabolic side effects as summarised in this review. These differences are important to consider when deciding which antipsychotic to use.

Treatment of difficult-to-treat depression - clinical guideline for selected interventions.

Background: Difficult-to-treat-depression (DTD) is a clinical challenge. The interventions that are well-established for DTD are not suitable or effective for all the patients. Therefore, more treatment options are highly warranted.

Use of social media and online dating among individuals with a history of affective disorder.

Objectives: To investigate how individuals with a history of affective disorder use and perceive their use of social media and online dating.

Methods: A questionnaire focusing on affective disorders and the use of social media and online dating was handed out to outpatients from unipolar depression and bipolar disorder clinics and general practice patients with or without a history of affective disorders (latter as controls). The association between affective disorders and use of social media and online dating was analysed using linear/logistic regression.

Mortality rate trends in patients diagnosed with schizophrenia or bipolar disorder: a nationwide study with 20 years of follow-up.

Background: Patients with severe mental illness (SMI) have a reduced life expectancy of one to two decades as compared to the general population, with most years of life lost due to somatic diseases. Most previous studies on disorders constituting SMI, e.g.

[Treatment of mania in adults].

Around 1% of the population will experience at least one episode of mania. Mania has negative social consequences, may lead to cognitive impairment and may even be lethal. Therefore, prompt and efficient medical action needs to be taken, not only addressing the acute symptoms but also the high risk of recurrence.