Publications by authors named "Sundus Ghuneim"
Reproduction
November 2024
Article Synopsis
- * Most existing studies focus on single phthalate exposures in animal models, leaving the effects of real-life mixtures and their impacts on women's reproductive health largely unexamined.
- * Recent literature indicates that high phthalate exposure is linked to menstrual irregularities, ovarian disorders, poor IVF outcomes, and adverse pregnancy results, highlighting the need for better research on phthalate mixtures and their mechanisms of toxicity.
J Am Heart Assoc
January 2024
Article Synopsis
- - The study explored how early life stress from maternal separation and early weaning (MSEW) impacts blood pressure in obese male mice, focusing on the role of the renin-angiotensin-aldosterone system.
- - Both control and MSEW mice on a high-fat diet showed similar increases in angiotensinogen levels, but there was no activation of the renin-angiotensin system in their fat or kidneys.
- - Despite a reduction in blood pressure after treating with an angiotensin-converting enzyme inhibitor, MSEW mice still experienced heightened sympathetic tone, indicating that other mechanisms beyond angiotensin II contribute to their elevated blood pressure.
