Publications by authors named "Sunday Adeniyi"
Article Synopsis
- The study aimed to investigate how alcohol consumption is linked to stroke occurrences in Nigeria and Ghana by comparing individuals who had strokes to those who didn't.!
- It involved over 7,368 participants, classifying them into groups based on their alcohol consumption habits, and utilized various statistical models to analyze the data.!
- Results indicated that current drinkers had a higher risk of stroke, particularly among moderate, binge, and heavy drinkers, while former drinkers showed no significant stroke risk. !
Background: Hypertension is preeminent among the vascular risk factors for stroke occurrence. The wide gaps in awareness, detection, treatment, and control rates of hypertension are fueling an epidemic of stroke in sub-Saharan Africa.
Purpose: To quantify the contribution of untreated, treated but uncontrolled, and controlled hypertension to stroke occurrence in Ghana and Nigeria.
Article Synopsis
- African ancestry populations have the highest stroke burden globally, yet the genetic factors contributing to stroke in these groups are not well understood, prompting the SIREN study in West Africa to investigate this.
- The study involved recruiting stroke patients and stroke-free controls to conduct a genome-wide association study (GWAS), leading to DNA analysis that identified significant SNPs near specific genes associated with stroke risk.
- Key findings highlighted protective genetic variants near AADACL2 and MIR5186 on chromosome 3, as well as other notable associations on chromosomes 5, 6, 12, 16, and 18, which could provide insights for future stroke risk assessment in these populations.
Dietary patterns associated with hypertension among stroke-free indigenous Africans: insights from the Stroke Investigative Research and Educational Network study.
J Hypertens
April 2024
Background: The dietary factors associated with the high burden of hypertension among indigenous Africans remain poorly understood. We assessed the relationship between dietary patterns and hypertension among indigenous Africans.
Method: In this study, 1550 participants with hypertension matched (for age: ± 5 years, sex and ethnicity) with 1550 participants without hypertension were identified from the stroke-free population in the Stroke Investigative Research and Educational Network study in Ghana and Nigeria.
Background: Spontaneous intracerebral hemorrhage (ICH) is associated with a high case fatality rate in resource-limited settings. The independent predictors of poor outcome after ICH in sub-Saharan Africa remains to be characterized in large epidemiological studies. We aimed to determine factors associated with 30-day fatality among West African patients with ICH.
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- Non-cigarette tobacco (NCT) use is linked to an increased risk of stroke among indigenous Africans, suggesting a need for better understanding and public health interventions.
- The study involved 7,617 respondents, showing that those who used smokeless NCT had a significant association with stroke, while smoked NCT did not show a strong link.
- Increased awareness and targeted policies are essential to address the rising burden of stroke related to NCT usage in the population.
Background: There is a growing interest in stroke genomics and neurobiobanking research in Africa. These raise several ethical issues, such as consent, re-use, data sharing, storage, and incidental result of biological samples. Despite the availability of ethical guidelines developed for research in Africa, there is paucity of information on how the research participants' perspectives could guide the research community on ethical issues in stroke genomics and neurobiobanking research.
View Article and Find Full Text PDFBackground: This study aimed to develop a risk-scoring model for hypertension among Africans.
Methods: In this study, 4413 stroke-free controls were used to develop the risk-scoring model for hypertension. Logistic regression models were applied to 13 risk factors.
Are there differences in perceptions, preferences and attitudes towards disclosure of genetic testing for Stroke? A qualitative study among stroke-free SIREN-SIBS genomics study participants.
J Stroke Cerebrovasc Dis
March 2023
Article Synopsis
- The study examined how stroke-free individuals and healthcare providers in Nigeria and Ghana perceive and prefer the disclosure of genetic testing results related to stroke.
- Findings indicated that healthcare professionals generally had a better understanding of genetic testing compared to family members, and suggested that relatives and religious figures are preferred for delivering sensitive results to patients.
- Challenges for effective disclosure included inadequate information, fear of stigma and familial distress, and a lack of awareness about national guidelines, highlighting the need for culturally tailored educational initiatives.
Background: Stroke is a leading cause of disability and mortality worldwide, but little is known about the contribution of secondhand smoke exposure (SHSE) to stroke epidemiology among indigenous Africans.
Objective: To evaluate the association of SHSE with stroke among indigenous Africans.
Methods: We analyzed the relationship of SHSE with stroke among 2990 case-control pairs of adults who had never smoked (identified in the SIREN study) using conditional logistic regression at a two-sided P < 0.
Article Synopsis
- The study explored the prevalence and implications of metabolic syndrome (METS) in African patients with newly diagnosed stroke, involving 3998 participants.
- Factors linked to METS included age over 50, male gender, higher income, stress, family history of diabetes, and cardiovascular disease.
- The findings revealed that METS was common among stroke patients and associated with greater stroke severity and a higher risk of death within one month of the stroke, highlighting the need for lifestyle interventions to mitigate these risks.
Article Synopsis
- The study investigates the awareness and willingness to donate biological samples for neurobiobanking in Ghana and Nigeria, revealing low levels of knowledge about blood and brain donation among community members.
- About a third of respondents knew about blood donation, while only 18.8% were willing to donate their brain after death, primarily due to cultural beliefs and lack of information.
- The research highlights the importance of targeted public education regarding neurobiobanking and informed consent in sub-Saharan Africa, taking into account the region's sociocultural diversity.
Article Synopsis
- The fields of stroke genomics, biobanking, and precision medicine are developing rapidly in sub-Saharan Africa, but ethical and social implications remain uncertain due to diverse cultural contexts.
- The African Neurobiobank for Precision Stroke Medicine-ELSI Project involves a collaborative effort across Ghana and Nigeria, focusing on building capacity through workshops with stakeholders to create and validate data collection instruments.
- Findings indicate that these workshops significantly improved participants' knowledge in genetic and genomic research, highlighted the need for culturally appropriate tools, and demonstrated that a developed mini-dictionary effectively enhanced understanding and engagement in genomic data collection.
Background: The relationship of diet with stroke risk among Africans is not well understood.
Aim: The aim of this study was to investigate the association between dietary patterns and stroke risk among West Africans.
Methods: In this multi-center case-control study, 3684 stroke patients matched (for age and sex) with 3684 healthy controls were recruited from Nigeria and Ghana.
A Novel Afrocentric Stroke Risk Assessment Score: Models from the Siren Study.
J Stroke Cerebrovasc Dis
October 2021
Background: Stroke risk can be quantified using risk factors whose effect sizes vary by geography and race. No stroke risk assessment tool exists to estimate aggregate stroke risk for indigenous African.
Objectives: To develop Afrocentric risk-scoring models for stroke occurrence.