Acute, Subchronic, and Genetic Toxicity Assessments of a Composition of Fruit Rind and Seed Extracts.

LN19183 is a standardized composition of (Christm) Swingle (CA) fruit rind and L. (TC) seed extracts that have recently been demonstrated to increase resting energy expenditure (REE) and reduce body fat in rats. CA and TC are important herbs in traditional medicine for various health benefits.

Safety assessment of a novel water-soluble extract of gum resin: acute toxicity, 90-day sub-chronic toxicity, Ames' bacterial reverse mutation, and micronucleus assays.

gum resin extracts have demonstrated potential benefits in alleviating joint pain and discomfort of osteoarthritis. The major objective of the present study was to assess the safety of a water-soluble gum resin extract (LI51202F1) in diverse models of acute oral, acute dermal, primary dermal irritation, eye irritation, and 90-day sub-chronic repeated dose toxicity studies, as well as Ames' bacterial reverse mutation assay and micronucleus assay. The acute oral and dermal toxicity studies in (SD) rats demonstrated that the median lethal dose (LD) of LI51202F1 is >2000 mg/kg body weight (BW).

Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Fruit Rind and Leaf Extracts (CinDura®).

The present communication describes a battery of toxicity studies that include an acute oral toxicity, a subacute twenty-eight-day repeated oral dose toxicity, and genotoxicity studies on a herbal formulation CinDura® (GMCT). This proprietary herbal composition contains the extracts of the fruit rind (GM) and the leaf (CT). The toxicological evaluations were performed following the Organization for Economic Cooperation and Development (OECD) guidelines.

Toxicological Assessment of a Standardized Gum Resin Extract.

The acidic and non-acidic fractions of gum resin extracts were combined to prepare a unique product, LI13019F1 (Serratrin). The present series of studies evaluated LI13019F1 for acute and subchronic (28-day) toxicity in Wistar rats and acute dermal and eye irritation in New Zealand white rabbits. The mutagenicity and clastogenicity of LI13019F1 were evaluated in bacteria and mouse bone marrow erythrocytes, respectively.

Toxicological studies on the botanical supplement LI12542F6 containing extracts of flower heads and (mango tree) bark.

LI12542F6, a botanical extract composed of and , was evaluated for mutagenicity in bacteria clastogenicity in mouse bone marrow, acute oral and dermal toxicity in the rat, irritation (dermal, eye) in rabbit, and subacute and subchronic toxicity (28 and 90 days) in the rat. All studies followed standard OECD test protocols, in accordance with the principles of Good Laboratory Practice (GLP). LI12542F6 did not induce mutations in the bacterial assay using and strains, nor did it induce genotoxic effects in erythrocytes from mouse bone marrow.