Development of an UPLC-MS/MS approach to detect and quantify N-nitroso mirabegron in mirabegron.

In the mirabegron (MIR) synthesis, the N-nitroso mirabegron (NNM) is obtained during synthetic process of MIR; water is being used in reaction under acidic condition. Nitrite source is from water, and secondary amine source is from MIR as it has secondary amine; NNM is generated as an impurity during the synthesis of MIR. The presence of NNM in MIR could potentially affect its effectiveness.

Hierarchical NaV(PO)F Microsphere Cathodes for High-Temperature Li-Ion Battery Application.

Sodium superionic conductor (NASICON)-structured NaV(PO)F cathode materials have received vast attention in the high-temperature storage performance due to their structural and thermal stability. Herein, hierarchical NaV(PO)F microspheres (NVPF-HMSs) consisting of nanocubes were designed by a one-pot facial solvothermal method. The hierarchical NaV(PO)F microsphere size is 2-3 μm, which is corroborated by FE-SEM and HR-TEM analyses.

Sustainable Synthesis of 2-Hydroxymethylbenzimidazoles using D-Fructose as a C Synthon.

D-fructose, a biomass-derived carbohydrate has been identified as an environmentally benign C synthon in the preparation of synthetically useful 2-hydroxymethylbenzimidazole derivatives by coupling with 1,2-phenylenediamines. Proof of concept was established by synthesizing 23 examples using BF .OEt (20 mol%), TBHP (5.

Metal-Free Synthesis of Benzimidazoles via Oxidative Cyclization of d-Glucose with -Phenylenediamines in Water.

d-Glucose has been identified as an efficient C1 synthon in the synthesis of benzimidazoles from -phenylenediamines via an oxidative cyclization strategy. Isotopic studies with C-d-glucose and DO unambiguously confirmed the source of methine. The notable features of this method include the following: broad functional group tolerance, a biorenewable methine source, excellent reaction yields, a short reaction time, water as an environmentally benign solvent, and the synthesis of vitamin component on the gram scale.