Publications by authors named "Sunali Wadehra"
Schizophrenia is a disorder characterized by brain network dysfunction, particularly during behavioral tasks that depend on frontal and hippocampal mechanisms. Here, we investigated network profiles of the regions of the frontal cortex during memory encoding and retrieval, phases of processing essential to associative memory. Schizophrenia patients (n = 12) and healthy control (HC) subjects (n = 10) participated in an established object-location associative memory paradigm that drives frontal-hippocampal interactions.
View Article and Find Full Text PDFThe 4th Schizophrenia International Research Society Conference was held in Florence, Italy, April 5-9, 2014 and this year had as its emphasis, "Fostering Collaboration in Schizophrenia Research". Student travel awardees served as rapporteurs for each oral session, summarized the important contributions of each session and then each report was integrated into a final summary of data discussed at the entire conference by topic. It is hoped that by combining data from different presentations, patterns of interest will emerge and thus lead to new progress for the future.
View Article and Find Full Text PDFArticle Synopsis
- Schizophrenia is marked by both disordered brain activation and connectivity, but there has been limited research examining both aspects together.
- A study involving 22 young adults found that those with schizophrenia showed higher activation levels but lower connectivity with the hippocampus during a task reliant on fronto-hippocampal connections.
- These findings suggest that schizophrenia may involve inefficient brain responses and poor integration of signals between regions, indicating a complex network dysfunction in the disorder.
Context: Disordered functional architecture of brain networks may contribute to the well-documented increased risk for psychiatric disorders in offspring of patients with schizophrenia.
Objective: To investigate aberrant interactions between regions associated with affective processing in children and adolescent offspring of patients with schizophrenia (HR-SCZ group) and healthy control subjects using dynamic causal modeling of functional magnetic resonance imaging data.
Design: Subjects participated in a continuous affective processing task during which positive, negative, and neutral valenced faces were presented.