Publications by authors named "Sunaina Devi"
Neuropsychopharmacology
May 2023
Article Synopsis
- CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental condition caused by mutations in the CDKL5 gene, leading to symptoms like early-onset seizures, intellectual disabilities, and visual impairments.
- The study focuses on the role of metabotropic glutamate receptors 5 (mGluR5) in CDD's pathology, indicating that the condition disrupts their function by affecting the binding and localization of the protein Homer1bc, essential for mGluR5 activity.
- Using positive-allosteric-modulators (PAMs) to stimulate mGluR5 in mouse models corrected synaptic and behavioral deficits, suggesting mGluR5 could be a viable target for developing therapies for
