Four Cases with FUS/CHOP Fusion Gene Products Positive Myxoid Liposarcoma Responding Effectively to Trabectedin Monotherapy.

Background: Myxoid liposarcoma, a rare type of tumor, accounts for approximately 30% of all liposarcomas. Myxoid liposarcomas harboring the FUS/CHOP fusion gene have shown promising results with trabectedin in basic research and some clinical experiments. However, the efficacy and safety of trabectedin in chemotherapy-naive soft tissue sarcomas or FUS/CHOP fusion gene-positive myxoid liposarcomas have not yet been established.

Effects of food containing strain T21 on the improvement of skin condition: a randomized, double-blind, placebo-controlled, parallel-group study.

This research aimed to examine the effect of daily intake of food containing strain T21 (T21) on skin conditions and inflammation-related markers in healthy adults who experience itching because of dry skin and have an atopic predisposition. A randomized, double-blind, placebo-controlled parallel-group study was conducted on 44 subjects aged 20 to 64 years. Subjects were randomly assigned to receive a T21-containing food or placebo daily for 8 weeks.

Effect of applying subsp. N793 to the scalps of men and women with thinning hair: a randomized, double-blind, placebo-controlled, parallel-group study.

subsp. N793 (N793) is a lactic acid bacterium (LAB) isolated from corn. We previously showed that N793 increases the level of keratinocyte growth factor, which is required for hair growth, in the culture supernatant of human follicle dermal papilla cells.

Spotlight on Zinc: Exploring the Visible Light Responsiveness of Zinc Complexes.

Group 12 element zinc(II)-based d complexes have long been known for their inherent colorlessness, which has limited their applications in visible light-driven photophysical and photochemical applications, despite the attractiveness of inexpensive and low-toxicity zinc metal. Based on precedents with nickel(0) and copper(I) complexes, which also adopt the d electronic configuration, achieving a visible light response from zinc(II) complexes seems feasible; however, investigations and proactive design strategies specifically tailored to zinc remain lacking. In this context, the present invited concept paper highlights zinc's potential for visible light responsiveness and evaluates how molecular designs can achieve this capability.

Reductive Retrocyclization of a Mangana(II)cyclopentasilane to Form Manganese(0) Bis(η-disilene) Complexes.

Ligand-exchange reactions on a mangana(II)cyclopentasilane complex that contains two THF ligands with aryl isocyanides led to the formation of manganese(0) bis(η-disilene) complexes via a retrocyclization. In stark contrast, ligand-exchange reactions with CNBu, an N-heterocyclic carbene, or pyridine-based ligands furnished manganese(II) complexes wherein the manganacyclopentasilane framework remained intact. The thermolysis of the obtained bis(η-disilene) complex in the presence of mesityl isocyanide led to the formation of a cyclotetrasilane via the formal dimerization of the two η-disilene moieties.

Planar three-coordinate iron(II) complexes supported by sterically demanding -Si(SiMe)(SiMeBu) ligands.

Sterically demanding organosilyl ligands support the formation of coordinatively unsaturated complexes. In this study, we found that using the ligand -Si(SiMe)(SiMeBu) affords exclusively planar three-coordinate iron bis(silyl) complexes that show good catalytic performance in the hydrosilylation of acetophenone.

Preoperative examination and intraoperative cerebrospinal fluid leakage test for minimally invasive surgery of spinal extradural arachnoid cysts: illustrative case.

Background: Spinal extradural arachnoid cysts (SEACs) are rare and can cause spinal dysfunction. Total cyst removal and duraplasty via multiple laminectomies are commonly performed. However, to avoid postoperative spinal deformity and axial pain, a minimally invasive surgery via selective laminectomy may be optimal.

Reduction-induced hapticity increase in a silacycle-bridged biaryl-based ligand coordinated to an iron center.

An Fe(II) bromide complex supported by a bidentate phosphine ligand and an η(C)-coordinated six-membered silacycle-bridged biphenyl-based ligand is converted upon reduction into an Fe(I) complex in which the hapticity of the silacycle-based ligand increases from η to η.

Four- and three-coordinate planar iron(II) complexes supported by bulky organosilyl ligands.

The ligand exchange reaction of (THF)Fe[Si(SiMe)] with 2 equivalents of an N-heterocyclic carbene (NHC) led to the formation of a square-planar iron(II) complex with -oriented -Si(SiMe) ligands. Conversely, the introduction of a -coordinate bidentate organosilyl ligand instead of -Si(SiMe) resulted in the formation of a square planar iron(II) complex supported by a -coordinate bidentate organosilyl ligand. A three-coordinate planar iron(II) bis(silyl) complex was also synthesized using a -coordinate bidentate organosilyl ligand and a cyclic (alkyl)(amino)carbene auxiliary ligand.

Visible Light Responsive Dinuclear Zinc Complex Consisting of Proximally Arranged Two d -Zinc Centers.

So far, Zn(II)-based d complexes have been known to be colorless unless they are accompanied by chromophoric groups, and therefore both fundamental and advanced photophysical performance of Zn centers of complexes, especially in visible-light regions has been unexplored. Here, we first demonstrate a dinuclear Zn(II) complex that shows visible light absorption using an orbital distributed over closely contacted two Zn centers experimentally determined by X-ray crystallography. A contrastive study demonstrated that intermetallic orbital interaction in dinuclear Zn(II) complex is responsible for capturing visible light to exhibit orangish yellow color, whereas an analogous one without such an interaction is colorless.

Iron(II) Complex with a Silacycle-Bridged Biaryl-Based Ligand.

Treatment of 2,6-dimethyl-1,1'-biphenyl-substituted chlorosilane with potassium followed by FeBr/TMEDA led to the formation of an iron(II) monobromide complex supported by a TMEDA ligand and a carbanion-based ligand containing a six-membered silacycle-bridged biphenyl skeleton. The obtained complex crystallized as a racemic mixture of (, ) and (, ) forms, in which the dihedral angle of the two phenyl rings of the biphenyl moiety was ∼43°.

[Therapeutics for Mitochondrial Encephalomyopathy].

In MELAS, taurine modification defect in the anticodon of mitochondrial leucine tRNA causes codon translation failure. An investigator-started clinical trials of high-dose taurine therapy, that showed its efficacy in preventing stroke-like episodes, and improving the taurine modification rate. The drug was found to be safe.

Dinuclear and tetranuclear group 10 metal complexes constructed from linear tetrasilane comprising both Si-H and Si-Si moieties.

The activation of Si-H bonds and/or Si-Si bonds in organosilicon compounds by transition-metal species plays a crucial role for the production of functional organosilicon compounds. Although group-10-metal species are frequently used to activate Si-H and/or Si-Si bonds, so far, systematic investigation to clarify the preferences of these metal species with respect to the activation of Si-H and/or Si-Si bonds remain elusive. Here, we report that platinum(0) species that bear isocyanide or N-heterocyclic-carbene (NHC) ligands selectively activates the terminal Si-H bonds of the linear tetrasilane Ph(H)SiSiPhSiPhSi(H)Ph in a stepwise manner, whereby the Si-Si bonds remain intact.

Human transthyretin gene expression is markedly increased in repair Schwann cells in an in vitro model of hereditary transthyretin amyloidosis.

Hereditary transthyretin (TTR) amyloidosis (ATTRv) is characterized by TTR amyloid deposition in the peripheral nervous system. It remains unknown why variant TTR preferentially deposits in the peripheral nerves and dorsal root ganglia. We previously detected low levels of TTR expression in Schwann cells and established an immortalized Schwann cell line, TgS1, derived from a mouse model of ATTRv amyloidosis expressing the variant TTR gene.

Germanium hydrides as an efficient hydrogen-storage material operated by an iron catalyst.

The use of metal hydrides such as NaBH as hydrogen-storage materials has recently received substantial research attention on account of the worldwide demand for the development of efficient hydrogen-production, -storage, and -transportation systems. Here, we report the quantitative production of H gas from a germanium hydride, PhGeH, mediated by an iron catalyst at room temperature dehydrogenative coupling, concomitant with the formation of (GePh). Of particular importance is that PhGeH can be facilely recovered from (GePh) by contact with 1 atm of H or PhICl/LiAlH at 0 °C or 40 °C, respectively.

Preoperative elevated eosinophils in peripheral blood for prediction of postoperative recurrence of chronic subdural hematoma.

Objective: Chronic subdural hematoma (CSDH) is a common neurological disease with a significant postoperative recurrence rate. There are numerous reported studies of the development of CSDH. In recent years, fibrinolysis, angiogenesis, and inflammation have all been identified as relevant factors in the development of CSDH.

Clinical Presentation, Treatment, and Outcome of Nontraumatic Subarachnoid Hemorrhage in Patients with Preceding Antithrombotic Therapy.

With the aging of the population, the number of people taking antithrombotic drugs is increasing. Few reports have described the clinical presentation, treatment, and outcomes of nontraumatic subarachnoid hemorrhage (SAH) in patients with preceding antithrombotic therapy. This study included 459 patients with nontraumatic SAH who had been treated between April 2009 and May 2021.

Becker Muscular Dystrophy Accompanied by Anti-HMGCR Antibody-positive Immune-mediated Necrotizing Myopathy.

Becker muscular dystrophy (BMD) is an X-linked neuromuscular disease characterized by progressive muscle weakness that currently has no cure. Immune-mediated necrotizing myopathy (IMNM) is a type of autoimmune inflammatory myopathy characterized by proximal muscle weakness that is treated with immunosuppressive therapy. We herein report a patient diagnosed with BMD complicated with IMNM by a pathological analysis.

Discrete palladium clusters that consist of two mutually bisecting perpendicular planes.

The construction of novel molecules with unprecedented alignments of the constituent elements has revolutionized the field of functional materials. The arrangement of two or more planar subunits in a mutually perpendicular fashion is a frequently encountered approach to produce novel functional materials. Previous examples of such materials can be categorized into two well-investigated families: -conjugated and dumbbell-shaped structures, wherein the two planes are aligned orthogonally a single atom or an axis, respectively.

Magnetic resonance imaging of dorsal root ganglion in a pre-symptomatic subject with familial amyloid polyneuropathy transthyretin E61K.

We recently reported evidence of transthyretin (TTR) familial amyloid polyneuropathy (TTR FAP) associated with TTR E61K, which is characterized by late-onset sensory dominant polyneuropathy, autonomic disturbances, and cardiomyopathy. In those TTR FAP patients, no amyloid deposits were observed in the endoneurium of examined sural nerves. Furthermore, the amyloidogenicity of E61K TTR was similar to that of wild-type TTR in vitro.