Publications by authors named "Sun-Hee Park"

Objectives: Although obesity is typically correlated with adverse outcomes in various diseases, certain acute critical illnesses exhibit a phenomenon known as the obesity paradox. This study evaluated sex-specific differences in the prognostic implications of the body mass index (BMI) of patients with severe acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT).

Design: A multicenter retrospective cohort study.

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  • The study examines the progression of acute kidney injury (AKI) to acute kidney disease (AKD) or chronic kidney disease (CKD) and aims to identify biomarkers and personalized treatments.
  • It involves a collaboration among eight Korean hospitals, where they gathered data from around 1,500 patients undergoing continuous kidney replacement therapy, using a combination of historical and ongoing patient information.
  • The research intends to develop an AI model to predict patient outcomes and guide tailored treatment plans, ultimately providing insights for better management and prevention of kidney-related diseases.
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  • - Diabetic nephropathy (DN) is a serious complication of diabetes leading to kidney failure, and this study investigates the role of neutrophil extracellular traps (NETs) in its development using mouse models.
  • - The research found that while certain NET-related proteins were generally absent in diabetic mice models, they were present in those with inflammation, indicating a complex relationship between hyperglycemia and inflammation in kidney disease.
  • - Ultimately, the study concludes that NETs are only produced in cases of inflammation associated with high blood sugar, emphasizing the need for further exploration into their role in diabetic kidney disease.
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Background: Mycophenolate mofetil (MMF) is usually prescribed with a reduced fixed dose in Asian kidney transplant recipients (KTRs). However, the clinical efficacy and safety of the fixed dose have not yet been investigated via therapeutic drug monitoring. We evaluated whether reduced fixed-dose MMF is an optimal dosing strategy to achieve the therapeutic target of mycophenolic acid (MPA) exposure in Korean KTRs.

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  • Immunoglobulin A nephropathy (IgAN) is the most common primary kidney disease worldwide, and this study investigates the impact of intrarenal vascular lesions on patient prognosis, as current grading systems largely overlook these lesions.
  • Conducted at Kyungpook National University Hospital from 2016 to 2021, the research analyzed the medical records of 138 IgAN patients, focusing on pathological features like fibrous intimal thickening and arteriolar wall thickening.
  • Results indicated that patients with arteriolar wall thickening had significantly lower kidney function (eGFR), higher serum creatinine, and increased global glomerulosclerosis, suggesting a link to more severe disease progression and potential end-stage renal disease.
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Biocides are used as preservatives in various household products, and 1,2-benzisothiazolin-3-one (BIT) is one of the popular chemicals. Therefore, BIT is highly likely to be exposed to human skin, necessitating dermal toxicity evaluation. In this study, we aimed to investigate dermal toxicity, eyes and skin irritation, and skin sensitization of BIT.

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  • An outbreak of Klebsiella spp. producing multiple carbapenemases was identified in a Korean hospital from July 2019 to August 2021, involving ten patients and an environmental isolate from a sink.
  • Whole-genome sequencing revealed that most isolates were closely related K. pneumoniae and K. variicola, sharing a plasmid that carries antibiotic resistance genes.
  • The study concluded that the spread was likely due to healthcare worker interactions and patient movement, highlighting the need for improved infection control measures to manage persistent pathogens.
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Background: Immunoglobulin A nephropathy (IgAN) is a major cause of end-stage kidney disease (ESKD). The International IgA Nephropathy Prediction Tool (IIgAN-PT) predicts IgAN prognosis, but improvement in the prediction performance using machine learning (ML)-based methods is needed.

Methods: We analyzed 4,425 biopsy-confirmed patients with IgAN and ≥6 months of follow-up from nine tertiary university hospitals in Korea.

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  • The study investigates the effects of a PEGylated PDZ peptide based on zonula occludens-1 (ZO-1) in managing systemic inflammation caused by lipopolysaccharide (LPS), a gram-negative bacterium.
  • The PDZ peptide administration showed promise by restoring tissue damage in organs like the kidneys, liver, and lungs, and lowering harmful biochemical markers in the blood.
  • Additionally, the peptide effectively reduced pro-inflammatory cytokines, modified macrophage populations towards a healing response, and inhibited key inflammatory signaling pathways, suggesting it could be a potential treatment for systemic inflammation.
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Early peritoneal dialysis (PD)-related infection is a severe complication. This study investigated the relationship between patient-doctor contact (PDC) duration and early PD-related infection. In the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) Korea, incident dialysis patients receiving PD were divided into two groups based on PDC duration (< 15 min versus ≥ 15 min), which was defined as the duration a nephrologist typically spends with a patient receiving PD during each visit according to the facility practice pattern.

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Background: Quality of life (QOL) is associated with mortality in dialysis patients. However, the impact of QOL index or score on elderly patients undergoing maintenance dialysis is unclear. We analyzed the relationship between QOL domains and survival in elderly end-stage renal disease (ESRD) patients on dialysis.

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Although pulmonary adenomas have been reported in ICR mice, spontaneous adenomas have not been reported in mice aged ≤10 weeks. Here, we report a well-circumscribed nodule (1 mm × 1 mm) in the peripheral lesion of the left lateral lobe of a 10-week-old male ICR mouse. Histopathologic evaluation revealed a well-demarcated nodule compressing the surrounding tissue.

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Introduction: Kidney transplantation (KT) improves the cardiovascular outcomes of patients with end-stage kidney disease. However, cardiovascular disease remains the leading cause of premature death and graft loss in KT recipients (KTRs) with diabetes. We evaluated the cardioprotective effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in KTRs with diabetes.

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Anti-phospholipid syndrome (APS) nephropathy is an autoimmune disease that is sometimes accompanied by systemic lupus erythematosus (SLE). Here, we report the use of rituximab to treat a case of APS nephropathy in a SLE patient with recurrent vascular thrombosis. A 52-year-old woman, who had been diagnosed with SLE 11 years earlier, was referred to a nephrology clinic for evaluation of azotaemia and proteinuria.

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Background: Solid-organ transplant recipients (SOTRs) receiving immunosuppressive therapy are expected to have worse clinical outcomes from coronavirus disease 2019 (COVID-19). However, published studies have shown mixed results, depending on adjustment for important confounders such as age, variants, and vaccination status.

Materials And Methods: We retrospectively collected the data on 7,327 patients hospitalized with COVID-19 from two tertiary hospitals with government-designated COVID-19 regional centers.

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  • Epithelial-to-mesenchymal transition (EMT) contributes significantly to peritoneal fibrosis, but its connection with autophagy is not well understood.
  • This study investigates how autophagy interacts with TGF-β1-induced EMT in human peritoneal mesothelial cells, finding that TGF-β1 promotes oxidative stress and mitochondrial damage through NOX4 activation.
  • The research suggests that targeting autophagy and NOX4 could be potential therapeutic strategies to prevent peritoneal fibrosis in patients undergoing dialysis.
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  • The study focused on acute rejection (AR) in kidney transplant recipients (KTRs) and evaluated the effectiveness of an integrated risk score based on omics biomarkers to predict AR.
  • It involved 40 high-immunologic-risk KTR patients and assessed various biomarkers over the first year post-transplant, adjusting immunosuppression for the biomarker group while the control group received standard treatment.
  • Results showed that the biomarker group had significantly fewer graft biopsies and required lower tacrolimus levels, indicating that omics-based monitoring could reduce unnecessary biopsies and help tailor immunosuppression strategies in preventing AR.
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Background: In South Korea, the National Immunization Program has included one-dose varicella vaccination for 1-year-olds since 2005. This study examines the potential impact of introducing a two-dose varicella vaccination for children, along with zoster vaccination for adults, using either the zoster vaccine live (ZVL) or recombinant zoster vaccine (RZV).

Methods: The investigation considered four strategies in a base case scenario.

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Background: Catheter-associated urinary tract infections (CAUTIs) account for a large proportion of healthcare-associated infections and have a significant impact on morbidity, length of hospital stay, and mortality. Adherence to the recommended infection prevention practices can effectively reduce the incidence of CAUTIs. This study aimed to assess the characteristics of CAUTIs and the efficacy of prevention programs across hospitals of various sizes.

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Background: Varying peritoneal dialysis (PD)-related clinical outcomes have been reported in different countries. As a participant of the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS), this study investigated the characteristics of Korean PD patients, PD facilities and the incidence rates of clinical outcomes including mortality and PD-related outcomes.

Methods: From July 2019 to December 2021, a total of 766 Korean PD patients were included for analysis.

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Background: Primary focal segmental glomerulosclerosis (FSGS) is a glomerular disease that sometimes recurs in patients after kidney transplantation (KT) and increases the risk of graft loss. Proteinuria is a common early sign of recurrent FSGS, but an abrupt decrease in urine volume is rare. Herein, we report a patient with early recurrence of FSGS with anuria following KT.

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Dual immunoglobulin domain-containing cell adhesion molecule (DICAM) is a type I transmembrane protein that presents in various cells including renal tubular cells. This study evaluated the expression and protective role of DICAM in renal tubular cell injury. HK-2 cells were incubated and treated with lipopolysaccharide (LPS, 30 μg/mL) or hydrogen peroxide (HO, 100 μM) for 24 h.

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  • The Korean Society of Nephrology has introduced the Kidney Health Plan 2033 (KHP 2033) to address rising chronic kidney disease (CKD) cases and related medical costs.
  • KHP 2033 aims to prevent the progression of kidney diseases, especially diabetic kidney disease, while promoting home therapies like peritoneal dialysis to reduce the socioeconomic burden.
  • The initiative emphasizes collaboration among patients, healthcare providers, and policymakers to work towards improving kidney health and overall quality of life in Korea.
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  • Chronic myelomonocytic leukemia (CMML) is a rare blood cancer that can rarely lead to acute kidney injury (AKI), especially when it transforms into acute myeloid leukemia (AML).
  • A case study details a 67-year-old man whose CMML transitioned into AML, resulting in severe AKI requiring hemodialysis, linked to leukemic infiltration as shown in kidney biopsy results.
  • The patient underwent chemotherapy for AML, leading to the recovery of his kidney function, highlighting the importance of monitoring kidney health in patients with CMML for possible transformation into AML.
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Cancer-induced bone pain (CIBP) is the most common and devastating symptom of bone metastatic cancer that substantially disrupts patients' quality of life. Currently, there are few effective analgesic treatments for CIBP other than opioids which come with severe side effects. In order to better understand the factors and mechanisms responsible for CIBP it is essential to have clinically relevant animal models that mirror pain-related symptoms and disease progression observed in patients with bone metastatic cancer.

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