Publications by authors named "Sun-Ha Choi"
Article Synopsis
- The study investigates the effects of durvalumab consolidation therapy on patients with non-small cell lung cancer (NSCLC) who have either mutant (EGFR M+) or wild-type (EGFR M-) epidermal growth factor receptors, specifically looking at programmed death-ligand 1 (PD-L1) expression levels.
- Of the 249 unresectable stage III NSCLC patients treated, only 12.4% had EGFR M+, with the median progression-free survival (PFS) being significantly longer in patients with high PD-L1 expression (≥50%) compared to those with EGFR M+ and low PD-L1 expression.
- The findings suggest that durvalumab can be beneficial for EGFR M+
Article Synopsis
- The study investigated the incidence and clinical significance of bacteremia in patients with complicated pleural infections, finding that 7% of the 341 patients had positive blood cultures.
- Blood cultures offered limited additional diagnostic information compared to pleural fluid cultures and did not affect in-hospital mortality rates significantly.
- The only factor closely linked to higher overall mortality was a higher RAPID score, indicating that blood cultures may benefit certain patients, particularly those with cavitary lesions or higher RAPID scores.
Article Synopsis
- The PACIFIC trial showed that durvalumab improves survival for certain lung cancer patients, but there’s limited data on its effectiveness in those aged 70 and older.
- A retrospective study analyzed 286 patients, revealing similar progression-free survival (PFS) and overall survival (OS) between elderly and younger groups, yet elderly patients had a lower completion rate of durvalumab.
- Elderly patients experienced more adverse events (AEs), especially pulmonary issues, suggesting the need for careful patient selection and monitoring when treating older patients with durvalumab.
Introduction: Data on factors related to mortality in patients with bronchiectasis exacerbation are insufficient. Computed tomography (CT) can measure the pectoralis muscle area (PMA) and is a useful tool to diagnose sarcopenia. This study aimed to evaluate whether PMA can predict mortality in patients with bronchiectasis exacerbation.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on the role of pleural fluid carcinoembryonic antigen (PF-CEA) levels in patients with advanced lung adenocarcinoma and malignant pleural effusion (MPE) in relation to epidermal growth factor receptor (EGFR) mutations and treatment outcomes.
- Findings reveal that higher PF-CEA levels are independently linked to a greater likelihood of EGFR mutations and are associated with improved survival rates in patients treated with EGFR-tyrosine kinase inhibitors (TKIs).
- The research underscores the need for careful evaluation of PF-CEA levels in lung cancer patients, as elevated levels could indicate useful insights for treatment strategies, even when cytology results are negative.
The data regarding pulmonary artery stump thrombosis (PAST) after lung cancer surgery are insufficient. The aim of the present study was to evaluate the incidence, clinical characteristics, and prognosis of PAST. We retrospectively investigated the incidence and clinical characteristics of PAST among patients who underwent lung resection for lung cancer at 2 institutions.
View Article and Find Full Text PDFBackground: Stenotrophomonas maltophilia has been increasingly recognized as an opportunistic pathogen associated with high morbidity and mortality. Data on the prognostic factors associated with S. maltophilia pneumonia in patients admitted to intensive care unit (ICU) are lacking.
View Article and Find Full Text PDFBackground: Neurogenic differentiation 1 (NeuroD1) is a representative small cell lung cancer (SCLC) transcription regulator involved in the carcinogenesis and behavior of SCLC. Histone modifications play an important role in transcription, and H3 lysine 4 trimethylation (H3K4me3) is primarily associated with promoter regions.
Methods: We investigated the association between single nucleotide polymorphisms (SNPs) in NeuroD1 and H3K4me3 coincident regions, selected using ChIP sequencing (ChIP-seq), and the clinical outcomes of 261 patients with SCLC.
Background: Patients with bronchiectasis commonly experience disease exacerbations, which cause significant morbidity and mortality. However, data regarding the clinical features of bronchiectasis patients hospitalized with hemoptysis are scarce.
Methods: We retrospectively collected the data of patients with bronchiectasis-associated hospitalization at a tertiary referral center in Korea, and classified them into the hemoptysis and infective exacerbation (IE) groups.
Introduction: Altered lipid metabolism has been reported to be associated with prognosis in multiple cancers. This study aimed to investigate the association of polymorphisms in lipid metabolism pathway genes with survival outcomes in patients with surgically resected non-small cell lung cancer (NSCLC).
Methods: In total, 744 patients with surgically resected NSCLC (380 in the discovery cohort and 364 in the validation cohort) were included in this study.
Article Synopsis
- Necroptosis, a type of regulated cell death linked to cancer progression, was studied to see how genetic variants in its regulators affect survival rates in non-small cell lung cancer (NSCLC) patients after surgery.
- Among 674 patients analyzed, two specific genetic variants (RIPK1 rs17548629C > T and MLKL rs877375G > C) showed a connection with improved overall and disease-free survival, particularly in those with adenocarcinoma.
- The study's findings suggest that these genetic variants could serve as useful biomarkers for predicting survival outcomes in NSCLC patients who have undergone surgical treatment.
Non-expandable lung (NEL) often occurs during pleural fluid drainage in patients with malignant pleural effusion (MPE). However, data regarding the predictors and prognostic impact of NEL on primary lung cancer patients with MPE receiving pleural fluid drainage, compared to malignant pleural mesothelioma (MPM), are limited. This study was aimed to investigate the clinical characteristics of lung cancer patients with MPE developing NEL following ultrasonography (USG)-guided percutaneous catheter drainage (PCD) and compare the clinical outcomes between those with and without NEL.
View Article and Find Full Text PDFBackground: Ultrasound (US)-guided percutaneous core needle biopsy (PCNB) has been used to diagnose subpleural lung lesions with high diagnostic performance and acceptable complication rates. However, with regard to the role of US-guided needle biopsy for the diagnosis of small (≤2 cm) subpleural lesions, limited information is available.
Methods: From April 2011 to October 2021, a total of 572 US-guided PCNBs in 572 patients were retrospectively reviewed.
Background: Regimens for the treatment of multidrug-resistant tuberculosis (MDR-TB) have been changed from injectable-containing regimens to all-oral regimens. The economic effectiveness of new all-oral regimens compared with conventional injectable-containing regimens was scarcely evaluated. This study was conducted to compare the cost-effectiveness between all-oral longer-course regimens (the oral regimen group) and conventional injectable-containing regimens (the control group) to treat newly diagnosed MDR-TB patients.
View Article and Find Full Text PDFSpirometry is an unrivalled tool for determining asthma and asthma severity. The ratio of forced expiratory volume (FEV) in 1 second (FEV) to forced vital capacity (FVC) and the forced expiratory flow between 25% and 75% of FVC (FEF) are well-known markers of airway obstruction, but they are limited by low reproducibility, particularly in children. In this study, we defined terminal expiration volume (TEV) as FEV in 3 seconds forced expiratory volume in 3 seconds (FEV₃) minus forced expiratory volume in 1 seconds (FEV) and investigate whether TEV/FEV₃ can function as a coherent marker to compensate for existing markers.
View Article and Find Full Text PDFBackground: Computed tomography (CT) is the mainstay imaging modality for suspected pleural malignancy. Tuberculous pleural effusion (TPE) can present with various pleural abnormalities. However, few studies have evaluated the different characteristics of pleural abnormalities on chest CT between TPE and malignant pleural effusion (MPE).
View Article and Find Full Text PDFLimited data exist about the comparative immune cell population profile determined by cytometry by time-of-flight (CyTOF) analysis between active tuberculosis (TB) and latent TB infection (LTBI). In this study, we performed CyTOF analysis using peripheral blood mononuclear cells (PBMCs) to compare the differential immune cellular profile between active TB and LTBI. A total of 51 subjects (active TB [n = 34] and LTBI [n = 17]) were included.
View Article and Find Full Text PDFArticle Synopsis
- NEUROD1 is often overexpressed in small-cell lung cancer (SCLC), playing a crucial role in enhancing cancer cell behavior and survival.
- A study involving 261 SCLC patients identified two specific single nucleotide polymorphisms (SNPs)—SEMA6A rs3806915C>A and NHLH1 rs11265375C>T—that were significantly linked to better chemotherapy responses and overall survival.
- The findings indicate that these SNPs influence the promoter activity of their respective genes, potentially impacting the survival outcomes of patients with SCLC.
Background: Data regarding the clinical characteristics and treatment outcomes of patients with community-acquired pneumonia (CAP) and bronchiectasis (BE) are rare. This study aims to elucidate the clinical relevance of BE in patients with CAP.
Methods: Patients hospitalized with CAP in a single center were retrospectively analyzed and divided into significant BE (BE with ≥ 3 lobes or cystic BE on computed tomography) and control groups.
Background: Despite therapeutic advances, lung cancer prognosis remains poor. Loss of heterozygosity (LOH) in the 3p21 region is well documented in lung cancer, but the specific causative genes have not been identified.
Materials And Methods: Here, we aimed to examine the clinical impact of miR-135a, located in the 3p21 region, in lung cancer.
Background: Gastric cancer adversely affects nutrition and immunity, while increasing the risk of tuberculosis (TB). This study investigated the incidence and risk factors for TB in gastric cancer patients who had undergone gastrectomy or endoscopic submucosal dissection (ESD).
Methods: This retrospective cohort study was conducted using Korean national insurance claims data.
Pemetrexed is an anti-folate agent which is one of the most frequently used chemotherapy agents for non-squamous non-small cell lung cancer (NSCLC) patients. However, clinical response to pemetrexed chemotherapy and survival outcome of patients varies significantly. We evaluated whether the genetic variants in miRNA target sites may affect the treatment outcome of pemetrexed chemotherapy in lung adenocarcinoma patients.
View Article and Find Full Text PDFArticle Synopsis
- This study explored how genetic variations in specific areas related to histone modification affect the effectiveness of PEM chemotherapy in lung adenocarcinoma patients.
- Researchers analyzed 279 single nucleotide polymorphisms (SNPs) in 314 patients and found that 18 SNPs influenced chemotherapy response, while 28 impacted overall survival.
- Notably, the SNP rs549794A>G was linked to poorer chemotherapy response and worse survival outcomes, with implications highlighting the role of the RPS3 gene in chemotherapy resistance.
Article Synopsis
- This study examined how genetic variations in the LKB1/AMPK/mTOR pathway affect treatment outcomes for non-small cell lung cancer (NSCLC) patients receiving chemotherapy.
- It involved 379 patients treated with first-line paclitaxel-cisplatin chemotherapy, focusing on 19 specific genetic variants.
- Two variants, AKT1 rs2494750G>C and TSC1 rs2809244C>A, were found to predict better chemotherapy response and overall survival, particularly in patients with adenocarcinoma.