ERAP1 Gene Variants and Haplotypes Associated With Psoriasis Vulgaris of Han Chinese in Inner Mongolia.

Background: This study aimed to investigate the association between genetic variants of ERAP1 (OMIM: 606832) and psoriasis vulgaris (PsV) susceptibility in Inner Mongolia Han nationality.

Methods: For primary screening, the subjects included 142 PsV cases and 100 healthy controls without psoriasis. The 27 exons of ERAP1 gene were sequenced to screen significant genetic variants.

[Research Advances in the Treatment of Eltrombopag for Adult Patients with Primary Immune Thrombocytopenia--Review].

Primary immune thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia, and T cell immune dysfunction plays an important role in the formation of ITP. As a thrombopoietin receptor agonist (TPO- RA), eltrombopag can not only directly stimulate megakaryocytes to produce platelets, but also play an immunomodulatory role by inducing regulatory T cell generation and reducing proinflammatory factors. As a second-line treatment drug for adult ITP, eltrombopag is increasingly widely used in clinical practice.

MCA Parallel Anatomic Scanning MR Imaging-Guided Recanalization of a Chronic Occluded MCA by Endovascular Treatment.

Basi-parallel anatomic scanning has been widely used for assessing the vascular morphology of vertebral basilar arteries. Previous studies have demonstrated its efficacy in evaluating the morphology of the MCA, which we refer to as MCA parallel anatomic scanning MR imaging (MCPAS). In this study, we present our experience with the application of MCPAS in patients with MCA occlusion.

Antiproliferative effects of isoalantolactone in human liver cancer cells are mediated through caspase-dependent apoptosis, ROS generation, suppression of cell migration and invasion and targeting Ras/Raf/MEK signalling pathway.

The main objective of this study was to evaluate the in vitro antiproliferative effects of isoalantolactone against liver cancer cells (Hep-G2) and also monitor its mechanism of action. The MTT assay was involved in proliferation assessments and phase contrast microscopy was used to check cellular morphology. Acridine orange/ethidium bromide staining along with western blotting was used to evaluate proapoptotic effects of isoalantolactone.

Deep investigation on different effects of Cl in transformation of reactive species in Fe(II)/NHOH/PDS and Fe(II)/NHOH/HO systems.

Hydroxylamine (NHOH) has been verified to efficiently strengthen pollutants oxidation in Fe(II)/peroxydisulfate (PDS) and Fe(II)/HO systems. However, the different effects of hydroxylamine salts types were rarely recognized. Herein, the effects of two commonly used hydroxylamine salts (i.

[UHPLC-Q-Exactive Orbitrap MS/MS-based rapid identification of chemical components in substance benchmark of Kaixin San].

Ultra-performance liquid chromatography-quadrupole-electrostatic field Orbitrap mass spectrometry(UHPLC-Q-Exactive Orbitrap MS/MS) was used for rapid identification of the chemical components in Kaixin San substance benchmark. The gradient elution was performed through a Waters ACQUITY~(TM) BEH C_(18) column(2.1 mm×150 mm, 1.

Formation of iodinated aromatic DBPs at different molar ratios of chlorine and nitrogen in iodide-containing water.

Variations in iodinated aromatic disinfection byproducts (DBPs) in the presence of I and organic compounds as a function of reaction time in different molar ratios (MRs) of HOCl:NH-N were investigated. Up to 17 kinds of iodinated aromatic DBPs were identified in the breakpoint chlorination of iodide (I)/organic (phenol, bisphenol S (BPS) and p-nitrophenol (p-NP)) systems, and the possible pathways for the formation of iodinated aromatic DBPs were proposed. The reaction pathways include HOCl/HOI electrophilic substitution and oxidation, while the dominant iodinated DBPs were quantified.

KIF22 promotes progress of esophageal squamous cell carcinoma cells and is negatively regulated by miR-122.

Esophageal squamous cell carcinoma (ESCC) increases at fast rate of all cancer types in China, which urges the investigations of its potential mechanism. In this research, a highly expressed kinesin superfamily protein 22 (KIF22) was founded both in ESCC tissues and cancer cell lines. The following experiments pointed out that down-regulation of KIF22 remarkably restrained the malignant progression of ESCC cells.

[Reaserch Advances on Induction of Fetal Hemoglobin (HbF) by Drugs in the Treatment of β-Thalassemia--Review].

β-thalassaemias are inherited hemoglobin disorders caused by defects in the β-globin gene. In recent years, researches have re-mentioned the therapeutic significance of drug-induced fetal hemoglobin (HbF), which can reduce the imbalance of α and β chains and improve the severity of anemia by increasing the expression of γ chain. Drug trials, such as hydroxyurea, thalidomide and desitabine have shown elevated hemoglobin, decreased blood transfusion dependence, and reduced symptoms other than anemia after treatment.

Dabigatran-induced chronic progressive immune hemolytic anemia: A case report.

Dabigatran is an orally active direct thrombin inhibitor, initially approved by FDA for the prophylaxis of stroke and systemic embolism in the setting of non-valvular atrial fibrillation (NVAF). Major bleeding is its most common adverse event which is of great concern. However, other types of adverse events such as esophagitis, esophageal ulcer, exanthem and pustular eruptions were reported increasingly in recent years.

Pathological response and serum VEGF changes during chemoradiotherapy for esophageal carcinoma.

The aim of this study was to observe pathological response and change in serum vascular endothelial growth factor (VEGF) in esophageal carcinoma (EC) during chemoradiotherapy (CRT).Eighty-nine patients diagnosed with EC were treated with radiotherapy at the Department of Radiotherapy of the Second People's Hospital of Changzhou between May 2008 and December 2014, including 65 patients with CRT. Gastroscopy and pathological examination were conducted 4 weeks afterwards.

Down-regulation of circPVRL3 promotes the proliferation and migration of gastric cancer cells.

Circular RNA (circRNA) is a key regulator in the development and progression of various types of carcinomas. However, its role in gastric cancer (GC) tumorigenesis is not well understood. The present study aimed to investigate the expression profile and potential modulation of circRNAs on GC carcinogenesis.

[Effects of cold-shock on the growth and flower bud differentiation of tomato seedlings under high temperature stress].

In order to explore the effects of cold-shock on the growth and flower bud differentiation of tomato seedlings under high temperature, tomato seedlings were subjected to cold-shock treat- ments every day with 10 °C for 10 minutes in. an artificial climate chamber. Tomato seedlings were treated with cold-shock at the first true leaf stage and the treatment lasted for 15 days.

[Mechanism of dwarfing effect of tomato (Solanum lycopersicon) seedlings induced by cold-shock treatment under high temperature stress].

To explore the dwarfing mechanism of tomato seedlings induced by cold-shock treatment followed by high temperature, tomato seedlings were subjected to cold-shock treatment once a day at 8:00 with temperature of 5, 10 and 15 °C for 10, 20 and 30 min, respectively, and ethylene production rate was measured. Plant height, ethylene production and gibberellin (GA3) content of the seedlings treated with T10 °C D10 min (cold-shock with 10 °C for 10 min), coupled with utilization of growth regulators, were also evaluated. The results showed that the release of ethylene was increased with the decrease of cold-shock temperature and extension of treatment time.

A case of tumor-like inflammatory demyelinating disease with progressive brain and spinal cord involvement.

Context: Tumor-like inflammatory demyelinating disease (TIDD) usually occurs in the brain and rarely occurs in the spinal cord. TIDD appears to be very similar to tumors such as gliomas on imaging, which may lead to incorrect or delayed diagnosis and treatment.

Case Report: Because of headache and incoherent speech, a 24-year-old Chinese male presented to our hospital with a two-week history of respiratory infections.

[Effects of cold-shock on tomato seedlings under high temperature stress].

High temperature stress (HTS) is one of the major limiting factors that affect the quality of intensively cultured seedlings in protected facilitates during hot season. Increasing the cross adaptive response of plant induced by temperature stress is an effective way to improve plant stress resistance. In order to explore the alleviating effect of cold-shock intensity on tomato seedlings under HTS, tomato seedlings were subjected to cold-shock treatments every day with 5 °C, 10 °C, and 15 °C for 10 min, 20 min, and 30 min, respectively, in an artificial climate chamber.

Pathologic response during chemo-radiotherapy and variation of serum VEGF levels could predict effects of chemo-radiotherapy in patients with esophageal cancer.

Background: To investigate the relationship between pathologic tumor response to concurrent chemo- radiotherapy and variation of serum VEGF in patients with esophageal cancer.

Materials And Methods: Forty six patients with esophageal cancer who were treated with concurrent chemo-radiotherapy were enrolled. Endoscopic and pathologic examination was conducted before and four weeks afterwards.

Radiobiological characteristics of cancer stem cells from esophageal cancer cell lines.

Aim: To study the cancer stem cell population in esophageal cancer cell lines KYSE-150 and TE-1 and identify whether the resulting stem-like spheroid cells display cancer stem cells and radiation resistance characteristics.

Methods: A serum-free medium (SFM) suspension was used to culture esophageal cancer stem cell lines and enrich the esophageal stem-like spheres. A reverse transcription polymerase chain reaction assay was used to detect stem cell gene expression in the spheroid cells.

Clinical trial of thalidomide combined with radiotherapy in patients with esophageal cancer.

Aim: To investigate the short-term efficacy and tolerability of radiotherapy plus thalidomide in patients with esophageal cancer (EC).

Methods: Serum samples from 86 EC patients were collected before, during, and after radiotherapy, and the vascular endothelial growth factor (VEGF) level was examined by ELISA. According to the change in serum VEGF level during radiotherapy, the patients were divided into two groups: in the drug group, VEGF level was increased or remained unchanged, and thalidomide was administered up to the end of radiotherapy; in the non-drug group, VEGF level was decreased and radiotherapy was given alone.

WWOX induces apoptosis and inhibits proliferation of human hepatoma cell line SMMC-7721.

Aim: To investigate the effects of the WWOX gene on the human hepatic carcinoma cell line SMMC-7721.

Methods: Full-length WWOX cDNA was amplified from normal human liver tissues. Full-length cDNA was subcloned into pEGFP-N1, a eukaryotic expression vector.

Elastic response and length change of single DNA molecules induced by a combination of cisplatin and transplatin.

Magnetic tweezers were employed to investigate the interactions between DNA and cisplatin (transplatin). Cisplatin shortened DNA and reduced its persistence length more significantly than transplatin due to the formation of many more diadducts than those formed by transplatin. Interestingly, the presence of transplatin could enhance the ability of cisplatin in shortening DNA.

[Effects of bortezomib alone or combined with arsenic trioxide on the apoptosis of Jurkat cells and expression of livin mRNA].

This study was aimed to investigate the effect of bortezomib alone or combined with arsenic trioxide on the apoptosis of Jurkat cells and expression of livin mRNA. The Jurkat cells were cultured and treated with different concentrations of bortezomib, arsenic trioxide or their combination for 24 hours. Then, the expression of livin mRNA was detected by RT-PCR, the cell proliferation was analyzed with MTT assay and flow cytometry.