Recent advances in green solvents-based liquid-phase microextraction techniques for chromatographic analysis of active components in traditional Chinese medicine.

Traditional Chinese medicine (TCM) is a treasure of China and a crucial part of traditional medicine in the world, particularly in many oriental countries. TCM is the core and basis of traditional medicine in clinical practice for numerous diseases, and performs important function in nutraceuticals and dietary supplements. However, it is extremely difficult to extract each active ingredient from TCM to elucidate the mechanism of TCM clinical efficacy due to numerous compounds in TCM, especially trace compounds.

Modified G-CSF/ATG-Based Haploidentical Transplantation Protocol in Pediatric Primary Hemophagocytic Lymphohistiocytosis: A Long-Term Follow-Up Single-Center Experience.

Background: Primary hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by immune dysregulation. Hematopoietic stem cell transplantation (HSCT) represents the only option for long-term cure for primary HLH. However, only around 25% of patients have a fully HLA-matched donor.

Bioaugmentation strategies in co-composting anaerobically digested food waste with agricultural by-products: Enhancing fertilizer quality and microbial communities.

Effective management of urban solid waste is critical for achieving sustainable development goals. One key aspect of this challenge is the recycling of anaerobically digested residues from anaerobic digestion of food waste, which plays a pivotal role in promoting sustainability. However, there is a gap in understanding the feasibility and effectiveness of converting these digested residues into valuable fertilizers through composting.

In-line tempering eliminates the domain boundary in perovskite single crystals for high-energy resolution ionizing radiation detectors.

Metal halide perovskite single crystals (SCs) emerge as a promising candidate for ionizing radiation detection. The realization of top-performing radiation detectors typically relies on careful crystal selection from broad candidate groups, as residual strain remains unavoidable during the SC growth process, which often leads to the formation of ferroelastic domains with varied orientations. Here, we introduce an in-line tempering strategy to alleviate microstrain and homogenize the domain orientation across methylammonium lead iodide (MAPbI) perovskite SCs.

Efficacy of forefoot scrubbing with bristled brush during foot and ankle surgery.

Background: The utility of forefoot cleaning using bristled brush has been proposed by previous studies but has not been tested in any study. The aim of the current study is to investigate the antiseptic efficacy of additional forefoot scrubbing with bristled brush after a standard 2-step preparation with alcohol and chlorhexidine in foot and ankle surgery.

Methods: One hundred patients underwent foot and ankle surgery by one orthopedic surgeon were included and categorized into one of two groups of different skin preparation procedure before surgery.

Oncolytic senecavirus A in tumor immunotherapy: Mechanisms, progress, and future directions.

Oncolytic virotherapy has emerged as a promising immunotherapy strategy against cancer. As the first picornavirus tested in humans for its oncolytic potential, Senecavirus A (SVA) possesses several advantageous features, including its small size, rapid replication, and ability to penetrate the vascular system of solid tumors, allowing for the specific targeting and lysis of tumor cells. Additionally, SVA does not integrate into the host genome, thus avoiding potential genomic damage, and it lacks oncogenes or other virulence genes.

Construction of poly (styrene-divinylbenzene)@tris(4-aminophenyl)amine-p-phthalaldehyde-triethylenetetramine core-shell microspheres for the preparation of ion chromatography stationary phase.

Core-shell composite microspheres are increasingly favored for the development of stationary phases due to their ability to integrate the monodispersity of inner core with the functional versatility of outer shell. In this study, poly(styrene-divinylbenzene)@(tris(4-aminophenyl)amine-p-phthalaldehyde-triethylenetetramine) (PS-DVB@TAPA-PPA-TETA) core-shell composite microspheres were constructed via an amine-aldehyde condensation reaction. The resultant microspheres were subsequently quaternized using the residual amine groups of TETA in the shell to create an effective anion-exchange stationary phase.

Active restoration efforts drive community succession and assembly in a desert during the past 53 years.

Regreening efforts in deserts have been implemented globally to combat land degradation and desert expansion, but how they affect above- and belowground community succession and assembly processes remains unknown. Here, we examined variations in plant and soil microbial community attributes along a 53-year restoration chronosequence following the establishment of straw checkerboard barriers (SCBs) in the Tengger Desert of China. This approach is a combination of fixing shifting sand and adding organic material (straw) simultaneously to expedite vegetation restoration by enhancing the success of plant establishment.

Immunostimulatory activity of sea buckthorn polysaccharides via TLR2/4-mediated MAPK and NF-κB signaling pathways in vitro and in vivo.

SP0.1-1, derived from Sea buckthorn (Hippophae rhamnoides L.), has been discovered to exhibit unique antioxidant activity.

Enhancing Motor Imagery Classification with Residual Graph Convolutional Networks and Multi-Feature Fusion.

Stroke, an abrupt cerebrovascular ailment resulting in brain tissue damage, has prompted the adoption of motor imagery (MI)-based brain-computer interface (BCI) systems in stroke rehabilitation. However, analyzing electroencephalogram (EEG) signals from stroke patients poses challenges. To address the issues of low accuracy and efficiency in EEG classification, particularly involving MI, the study proposes a residual graph convolutional network (M-ResGCN) framework based on the modified -transform (MST), and introduces the self-attention mechanism into residual graph convolutional network (ResGCN).

A multi-feature fusion graph attention network for decoding motor imagery intention in spinal cord injury patients.

Electroencephalogram (EEG) signals exhibit multi-domain features, and electrode distributions follow non-Euclidean topology. To fully resolve the EEG signals, this study proposes a Temporal-Frequency-Spatial multi-domain feature fusion Graph Attention Network (TFSGAT) for motor imagery (MI) intention recognition in spinal cord injury (SCI) patients. The proposed model uses phase-locked value (PLV) to extract spatial phase connectivity information between EEG channels and continuous wavelet transform to extract valid EEG information in the time-frequency domain.

cGAS regulates metabolic reprogramming independently of STING pathway in colorectal cancer.

Background: Cyclic GMP-AMP synthase (cGAS) is widely acknowledged for detecting cytosolic chromatin fragments and triggering innate immune responses through the production of the second messenger cGAMP, which subsequently activates the adaptor protein STING. However, the role of cGAS in regulating metabolic reprogramming independently of STING activation has not yet been explored.

Methods: Gene set enrichment pathway analysis (GSEA) based on TCGA transcriptomics, combined with Seahorse metabolic analysis of CRC cell lines and human normal colonic mucosa cell line FHC, was performed to profile the metabolic features in CRC.

A mini review of polysaccharides from Zanthoxylum bungeanum maxim: Their extraction, purification, structural characteristics, bioactivity and potential applications.

Zanthoxylum bungeanum Maxim (Z. bungeanum), commonly known as Sichuan pepper or Chinese prickly ash, is a deciduous shrub in the Rutaceae family, with a lengthy history of use as a food ingredient and traditional medicine in China. Z.

Review of polysaccharides from Citrus medica L. var. sarcodactylis. (Fingered citron): Their extraction, purification, structural characteristics, bioactivity and potential applications.

Citrus medica L. var. sarcodactylis.

A tissue bandage for pelvic ganglia injury.

Neurogenic bladder often occurs after pelvic ganglia injury. Its symptoms, like severe urinary retention and incontinence, have a significant impact on individuals' quality of life. Unfortunately, there are currently no effective treatments available for this type of injury.

POM-Based Hydrogels for Efficient Synergistic Chemodynamic/Low-Temperature Photothermal Antibacterial Therapy.

Bacterial infection of wound surfaces has posed a significant threat to human health and represents a formidable challenge in the clinical treatment. In this study, a novel antimicrobial hydrogel utilizing POM is synthesized as the primary component, with gelatin and sodium alginate as the structural framework. The resultant hydrogel demonstrates exceptional mechanical properties and viscoelasticity attributed to the hydrogen-bonded cross-linking between POM and gelatin, as well as the ionic cross-linking between sodium alginate and Ca.

Fu brick tea polysaccharides: A state-of-the-art mini-review on extraction, purification, characteristics, bioactivities and applications.

Fu brick tea (FBT), a post-fermented dark tea, is highly esteemed for its abundant nutritional and medicinal values. Fu brick polysaccharides (FBTPs) are acidic heteropolysaccharides primarily composed of galactose and galacturonic acid, which are crucial components of FBT. FBTPs exhibit multiple bioactivities, including immunomodulatory, antioxidant, anti-inflammatory, regulatory effects on intestinal microbiota, anti-obesity, among others.