Publications by authors named "Sun Young Nam"

Aims: Osteoarthritis (OA) is a chronic joint disorder marked by cartilage breakdown, bone alterations, and inflammation, leading to significant pain and disability. Current therapeutic strategies, ranging from lifestyle interventions to pharmacological and surgical treatments, offer limited efficacy and are often accompanied by side effects. This study investigates the potential of Polydioxanone (PDO), a biocompatible synthetic polymer, as a novel intra-articular (IA) viscosupplement in OA.

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Introduction: Wound healing is a complex process involving multiple stages, including inflammation, proliferation, and remodeling. Effective wound management strategies are essential for accelerating healing and improving outcomes. The CELLADEEP patch, incorporating iontophoresis therapy and microneedle technology, was evaluated for its potential to enhance the wound healing process.

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  • Electrosurgical electrodes are commonly used in surgeries, and this study assessed their efficacy and safety in minimizing thermal injuries in animal organs during minimally invasive procedures.
  • The study involved testing the AE40-300 (LIPO) and AE20-80 (LIFT) electrodes on tissue from minipigs, focusing on thermal spread and temperature changes.
  • Results showed that these electrodes produced lower surgical temperatures and smaller areas of thermal injury compared to older devices, suggesting they are safer for clinical use.
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Background: Microneedles are tiny needles, typically ranging from tens to hundreds of micrometers in length, used in various medical procedures and treatments. The tested medical device named "CELLADEEP Patch" a dissolvable microneedle therapy system (MTS), made of hyaluronic acid and collagen. And the iontophoresis technique is also applied in the system.

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  • * Over 12 days, hair follicle characteristics were measured, revealing that the combination of these treatments notably enhanced hair elongation and preserved hair bulb diameter, indicating potential for continuous hair growth.
  • * The findings suggest that these formulations could effectively promote hair growth while lowering the transition to the catagen stage, presenting promising alternatives for hair loss treatments comparable to conventional products.
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  • Human skin has special materials that help cells work, but they can sometimes cause the body to react badly, so a process called decellularization is used to make them safer.
  • Acellular dermal matrices (ADMs) are important for healing tissues and are used in surgeries to make things look better and reduce risks.
  • A study on a new type of ADM made with supercritical carbon dioxide showed it was safe and helped reduce inflammation and improve healing in rat models, which means it has great potential for use in medical treatments.
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The study aimed to explore the impact of a novel near-infrared LED (nNIR) with an extended spectrum on skin enhancement and hair growth. Various LED sources, including White and nNIRs, were compared across multiple parameters: cytotoxicity, adenosine triphosphate (ATP) synthesis, reactive oxygen species (ROS) reduction, skin thickness, collagen synthesis, collagenase expression, and hair follicle growth. Experiments were conducted on human skin cells and animal models.

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  • The Royal Oji Complex (ROC) is being studied for its effectiveness on the skin of children aged 0 to 3 years old, using keratinocytes from this age group and focusing on natural ingredients.
  • The study measured the impact of different ROC concentrations (0.1, 1, and 10 ppm) on essential genes for skin health and hydration, such as HAS3, IVL, LOR, and CLD1, using advanced techniques like qRT-PCR and ELISA.
  • Results showed that ROC significantly boosted HAS3 gene expression, suggesting benefits for skin hydration, while other genes responded differently at varying concentrations, indicating ROC's complex influence on young children's skin health.
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  • - The study focused on the ULTRACOL200 injectable filler, which uses polydioxanone (PDO) to promote collagen production and improve skin appearance, aiming to assess its effectiveness compared to other fillers.
  • - 31 participants aged 20 to 59 received injections of ULTRACOL200, and their skin texture and volume were measured at three different times: before treatment, 4 weeks after the first treatment, and 4 weeks after a second treatment.
  • - Results showed significant improvements in skin texture and reduced wrinkles, with participants reporting satisfaction after the treatments, highlighting the potential of PDO-based fillers for skin enhancement.
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Recipient site preparation using external volume expansion (EVE) increases graft survival in large-volume fat grafting. To improve patient compliance with using the device, we tested a new cyclic high negative-pressure (CHNP) mode that involves 1 h/day at -55 mm Hg, cycled between 1-second negative-pressure activation, followed by a 2-second deactivation period in an animal model. A miniaturized EVE device was applied to 30 8-week-old male Sprague-Dawley rats.

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Tissue engineering scaffolds are often made from the decellularization of tissues. The decellularization of tissues caused by prolonged contact with aqueous detergents might harm the microstructure and leave cytotoxic residues. In this research, we developed a new technique to use supercritical carbon dioxide (Sc-CO)-based decellularization for porcine nerve tissue.

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  • This study looks at using a silicone patch with zirconium-based metal-organic frameworks (Zr-MOF-808) to reduce hypertrophic scars (HS), which are raised scars formed due to excessive healing.
  • In an experiment with rabbits, the researchers applied different treatments, including a Zr-MOF-808 silicone patch to see its effects compared to no treatment and a regular silicone patch.
  • Results showed that the Zr-MOF-808 patch significantly reduced scar thickness and collagen density, leading to smoother and less noticeable scars, indicating its potential for improving wound healing.
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  • Lymphedema is a tissue swelling disease caused by fluid buildup in the lymphatic system, and early detection is crucial but challenging due to reliance on expensive diagnostic methods and subtle initial symptoms.* -
  • The study proposed using new data types like blood tests and therapy records to improve predictive models for lymphedema, rather than just depending on patient-reported symptoms, which can be unreliable.* -
  • Researchers collected data from 2137 patients and utilized various machine learning algorithms, achieving promising results, particularly with the random forest model, and created a web application to help doctors quickly screen for lymphedema.*
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The regulation of proinflammatory mediators has been explored to promote natural healing without abnormal inflammation or autoimmune response induced by their overproduction. However, most efforts to control these mediators have relied on pharmacological substances that are directly engaged in biological cycles. It is believed that functional porous materials removing target mediators provide a new way to promote the healing process using their adsorption mechanisms.

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A versatile hydrogel was developed for enhancing bioactive wound healing by introducing the amphiphilic GHK peptide (GHK-C16) into a photo-crosslinkable tyramine-modified hyaluronic acid (HA-Ty). GHK-C16 self-assembled into GHK nanofibers (GHK NF) in HA-Ty solution, which underwent in situ gelation after the wound area was filled with precursor solution. Blue light irradiation (460-490 nm), with riboflavin phosphate as a photoinitiator, was used to trigger crosslinking, which enhanced the stability of the highly degradable hyaluronic acid and enabled sustained release of the nanostructured GHK derivatives.

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When considering surgery for patients with breast cancer-related lymphedema (BCRL), it is crucial to determine which surgery will be most effective for the patient and establish the indications for each surgery. Our study retrospectively compared the results of preoperative noncontrast MR lymphangiography (NMRL) performed on the lymphedematous limb of patients before surgery, with the aim of analyzing whether preoperative NMRL can be used as a criterion for determining the type of surgery. From January 2020 to June 2022, a total of 138 patients with lymphedema underwent surgery at Seoul National University Bundang Hospital.

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Background: This study aimed to discuss several surgical approaches for advanced-stage breast cancer-related lymphedema and compared their treatment outcomes.

Methods: The patients who underwent surgery with International Society of Lymphology stage III lymphedema were included in this study. The three surgical methods used here were (1) suction-assisted lipectomy with lymphovenous anastomosis, (2) autologous breast reconstruction with muscle-sparing transverse rectus abdominis muscle flap combined with inguinal lymph node transfer, and (3) vascularized lymph node transfer with free omental flap.

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Background/aim: Chitosan-based functional materials have attracted considerable attention worldwide for applications in wound healing, especially in skin wound healing, due to their efficiency in hemostasis, anti-bacterial, and skin regeneration. Various chitosan-based products have been developed for skin wound healing applications, but most of these face limitations in either efficacy or cost-effectiveness. Therefore, there is a need to develop a unique material that can handle all of these concerns and be utilized for acute and chronic wounds.

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Aims: The objective of this study is to provide a reliable strategy for the diagnosis of sarcopenia based on a complementary combination of biomarkers from various approaches.

Material And Methods: A total of 30 C57BL/6J mice were used for the experiment, in which 15 young mice (YM) at 24 weeks old and 15 aged mice (AM) at 88 weeks old. Extracted features-based digital biomarkers from the electromyography activity of tibialis anterior muscles were evaluated by using receiver operating characteristic analysis.

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Allotransplantation, performed using an acellular dermal matrix (ADM), plays a significant role in the cultivation of constituted and damaged organs in clinical. Herein, we fabricated an innovative ADM for allografting derived from decellularized human skin by utilizing the supercritical fluid of carbon dioxide to eliminate immunogenic components. By using histological staining, the ADM product demonstrated the successful removal of cellular constituents without exerting any harmful influence on the extracellular matrix.

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Background/aim: Silicone implants are widely used biomaterials in surgeries owing to their physiological inertness and low toxicity. However, capsular contracture is a severe complication caused by the insertion of breast implants, which can endanger the health of patients. In this study, twelve different silicone breast implants were tested to determine which could lead to a lower incidence of capsular contracture.

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Wound healing is a recovering process of damaged tissues by replacing dysfunctional injured cellular structures. Natural compounds for wound treatment have been widely used for centuries. Numerous published works provided reviews of natural compounds for wound healing applications, which separated the approaches based on different categories such as characteristics, bioactivities, and modes of action.

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Lymphedema is a progressive disease caused by lymphatic flow blockage in the lymphatic pathway. Primary (hereditary) lymphedema is caused by genetic mutations without secondary causes. We performed clinical profiling on Korean primary lymphedema patients based on their phenotypes using lymphoscintigraphy and made genetic diagnoses using a next-generation sequencing panel consisting of 60 genes known to be related to primary lymphedema and vascular anomalies.

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Background/aim: Hypertrophic scars (HS) are the result of pathological wound healing characterized by a red, raised scar formation. The goal of this research was development of a new method for treatment of HS formation.

Materials And Methods: A tranilast-loaded microneedle (TMN) was developed and applied in a rabbit ear model to treat an induced HS.

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Background/aim: The skin plays an important role in protecting the body from mechanical damage, microbial infection, ultraviolet radiation, and extreme temperatures. Many products as well as ongoing studies have focused on skin injury and repair; however, unlimited challenges are still being faced. Furthermore, the drugs that are currently on the market are not adequate to meet the increasing medical needs.

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