Correction: Li et al. Preliminary Evaluation of Protective Efficacy of Inactivated Senecavirus A on Pigs. 2021, , 157.

In the original publication, there was a mistake in Figure 1B(b,c) as published [...

End-to-end multi-scale residual network with parallel attention mechanism for fault diagnosis under noise and small samples.

When the fault diagnosis datasets contains noise disturbances, small samples, compound faults, and mixed conditions, the feature extraction capability of the neural network will face significant challenges. This paper proposes an end-to-end multi-scale residual network with parallel attention mechanism to address the above complex problems. Firstly, the adaptive mixing pooling method is employed to facilitate the model's ability to retain effective feature information present within the timing signal.

Epidemiologic Investigation and Genetic Variation Analysis of PRRSV, PCV2, and PCV3 in Guangdong Province, China from 2020 to 2022.

Recently, the emergence of HP-PRRSV (Highly Pathogenic porcine reproductive and respiratory syndrome virus) and the exacerbation of mixed infections of PRRSV and PCV have resulted in significant economic losses for the Chinese pig industry. This study collected a total of 226 samples suspected of infection with the aforementioned viruses from diverse pig farms in seven urban districts of central and northern Guangdong Province between 2020 and 2022. The positive rates of PRRSV, PCV2, and PCV3 in the samples were 33.

Application of bone perforation in the surgery of medication-related osteonecrosis of the jaw in stage Ⅱ.

Objectives: This study aimed to explore the effect of surgery combined with bone perforation for treating stage Ⅱ medication-related osteonecrosis of the jaw (MRONJ).

Methods: A total of 21 patients with stage Ⅱ mandibular MRONJ who underwent surgical treatment from June 2020 to June 2023 were included in this study. Retrospective analysis was conducted on their clinical data, including gender, age, primary disease, drug name and administration method, pre-surgery drug cessation, and prognosis.

A review of the pollution signatures of polycyclic aromatic hydrocarbons in the sediments of the East China Sea.

Marine sediments serve as crucial reservoirs for polycyclic aromatic hydrocarbons (PAHs), and their PAH signatures offer valuable historical pollution records. This article provides a comprehensive review of the pollution status of 16 priority PAHs in more than 1000 sediments from the East China Sea (ECS). It focuses on the PAH sources, spatiotemporal distributions, driving factors, and ecological risks, with information derived from peer-reviewed papers published between 2003 and 2023.

Colon microbiota and metabolite potential impact on tail fat deposition of Altay sheep.

Unlabelled: Tail fat deposition of Altay sheep not only increased the cost of feeding but also reduced the economic value of meat. Currently, because artificial tail removal and gene modification methods cannot solve this problem, it is maybe to consider reducing tail fat deposition from the path of intestinal microbiota and metabolite. We measured body weight and tail fat weight, collected the serum for hormone detection by enzyme-linked immunosorbent assay, and collected colon contents to 16S rRNA sequence and liquid chromotography with mass spectrometry detection to obtain colon microbiota and metabolite information, from 12 3-month-old and 6-month-old Altay sheep.

A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM.

Osteoarthritis (OA) is characterized by progressive and irreversible damage to the articular cartilage and a consecutive inflammatory response. However, the majority of clinical drugs for OA treatment only alleviate symptoms without addressing the fundamental pathology. To mitigate this issue, we developed an inflammation-responsive carrier and encapsulated bioactive material, namely, LDH@TAGel.

IL-36 antagonism blunts the proliferation and migration of oral squamous cell carcinoma cells.

IL-36 is known to mediate inflammation and fibrosis. Nevertheless, IL-36 signalling axis has also been implicated in cancer, although understanding of exact contribution of IL-36 to cancer progression is very limited, partly due to existence of multiple IL-36 ligands with agonistic and antagonistic function. Here we explored the role of IL-36 in oral squamous cell carcinoma (OSCC).

Preliminary view of the distribution and spread of the plasmid-mediated resistance genes in .

. Various plasmid-mediated resistance genes have been reported in , but little is known about their global distribution features, evolution pattern and spread..

Characterization and Assessment of Sheep-Origin Probiotic Bacillus licheniformis B63 Strain for Potential Use in Intestinal Health and Disease.

Bacterial diarrhea causes serious losses for the sheep industry. Antibiotic resistance acquired by diarrheal bacteria is still a hurdle in the care of animal health. Thus, it is urgent to develop effective alternatives to antibiotics for controlling bacterial diarrhea.

Prognostic impact of muscle invasion in buccal mucosa squamous cell carcinoma.

Objective: The objective of the study was to assess the prognostic value of muscle invasion (MI), a key histopathological feature of tumor aggressiveness, and construct a superior prognostic prediction model combining the current TNM staging system.

Materials And Methods: MI was analyzed in the whole-slide images from a total of 301 patients with primary buccal mucosa squamous cell carcinoma (BMSCC). Survival times of patients with/without MI were evaluated by Kaplan-Meier analysis.

Changes in condylar position and morphology after mandibular reconstruction by vascularized fibular free flap with condyle preservation.

Objects: Changes in condylar position and morphology after mandibular reconstruction are important to aesthetic and functional rehabilitation. We evaluated changes in condylar position and morphology at different stages after mandibular reconstruction using vascularized fibular free flap with condyle preservation.

Materials And Methods: A total of 23 patients who underwent mandibular reconstruction with fibular flap were included in this retrospective study.

Soluble Expression of Antimicrobial Peptide BSN-37 from Escherichia coli by SUMO Fusion Technology.

Antimicrobial peptides (AMPs) are a kind of small molecular peptide that an organism produces to resist the invasion of foreign microorganisms. AMP BSN-37 is a bovine AMP that exhibits high antibacterial activity. In this paper, the optimized gene AMP BSN-37 was cloned into pCold-SUMO for fusion expression by recombinant DNA technology.

Evolutionary dynamics and adaptive analysis of Seneca Valley virus.

Over the past 20 years, the Seneca Valley virus (SVV) has emerged in various countries and regions around the world. Infected pigs display symptoms similar to foot-and-mouth disease and other vesicular diseases, causing severe economic losses to affected countries. In recent years, the number of SVV infections has been increasing in Brazil, China, and the United States.

Development and Comparative Analysis of an Early Prediction Model for Acute Kidney Injury within 72-Hours Post-ICU Admission Using Evidence from the MIMIC-III Database.

Background: Prompt recognition of patients predisposed to acute kidney injury (AKI) within 72 hours of intensive care unit (ICU) admission holds significant clinical importance as it can considerably lower mortality rates. However, existing AKI prediction models often require complex data collection yet yield only moderate performance. This study aims to develop a straightforward and efficient AKI prediction model, providing ICU physicians with a powerful tool to expedite the detection of AKI patients.

Oral tongue squamous cell carcinoma diagnosis from tissue metabolic profiling.

Objective: Disease metabolomes have been studied for identifying diagnostic and predictive biomarkers of pathology. Oral tongue squamous cell carcinoma (OTSCC) is one of the most prevalent subtypes of head and neck squamous cell carcinoma, yet the profile and diagnostic value of its tissue metabolite are unclear.

Subjects And Methods: Tumor tissue samples and matched normal mucosal tissue samples were collected from 40 OTSCC patients.

Kinetically Controlled Star Copolymer Self-Assembly for Rapid Fabrication of Nanoparticles with High Encapsulation Capacity.

Rapid and scalable self-assembly of an amphiphilic 21-arm star copolymer, (polystyrene-block-polyethylene glycol) [(PS-b-PEG) ] in aqueous solution has been performed by reverse solvent exchange procedure. Transmission electron microscope (TEM) and nanoparticle tracking analysis (NTA) reveal the formation of nanoparticles with narrow size distribution. Further investigation indicates a kinetically controlled self-assembly mechanism of the copolymers, in which the star topology of the amphiphilic copolymer and deep quenching condition by reverse solvent exchange are key to accelerate intrachain contraction of the copolymer during phase separation.

Multiperspective quantitative tumor-stroma ratio reveals histological areas associated with poor outcomes in oral squamous cell carcinoma.

Aims: Different regions of oral squamous cell carcinoma (OSCC) have particular histopathological characteristics, and the individual histological characteristics of the tumors are poorly understood. Therefore, calculating the proportion of tumor cells in different regions that allow assessment of the prognostic outcomes for OSCC patients would be of great clinical significance.

Methods And Results: We established an open-source software-based analytic pipeline that defines the inner tumor and invasive tumor front (ITF) in pancytokeratin-stained whole slide images (WSIs) and quantifies the tumor-stroma ratio (TSR) within the two regions.

Recombinant Antimicrobial Peptide OaBac5mini Alleviates Inflammation in Pullorum Disease Chicks by Modulating TLR4/MyD88/NF-κB Pathway.

Pullorum disease (PD), caused by Pullorum (. Pullorum), is a serious threat to the poultry industry worldwide. Antimicrobial peptides (AMPs) have drawn extensive attention as new-generation antibiotics because of their broad antimicrobial spectrum, low resistance, and low cytotoxicity.

Reinforcing supramolecular hyaluronan hydrogels via kinetically interlocking multiple-units strategy.

Supramolecular hydrogels exhibit promising potential in biological and clinical fields due to their special dynamic properties. However, most existing supramolecular hydrogels suffer from poor mechanical strength, which severely limits their applications. Here in this study, the Kinetically Interlocking Multiple-Units (KIMU) strategy was applied to the hyaluronan networks by introducing different supramolecular interaction motifs in an organized and alternative manner.

Characteristics of antimicrobial peptide OaBac5mini and its bactericidal mechanism against .

Introduction: Antimicrobial peptides (AMPs) play an important role in defending against the attack of pathogenic microorganisms. Among them, the proline-rich antibacterial peptides (PrAMPs) have been attracting close attention due to their simple structure, strong antibacterial activity, and low cell toxicity. OaBac5mini is an active fragment of the sheep-derived OaBac5 belonging to the PrAMPs family.

Evaluation of the efficacy of the antimicrobial peptide HJH-3 in chickens infected with Pullorum.

As a promising substitute for antibiotics, increasing attention has been given to the clinical application of antimicrobial peptides (AMPs). In this study, the mode of action of the HJH-3 against Pullorum was investigated. The structure and properties of HJH-3 were examined , and minimum inhibitory concentrations (MICs) were determined to evaluate its antimicrobial spectrum.