Associations of maternal ozone exposures during pregnancy with maternal blood pressure and risk of hypertensive disorders of pregnancy: A birth cohort study in Guangzhou, China.

Although studies have assessed the associations of maternal exposure to ozone (O) during pregnancy with blood pressure and the risk of hypertensive disorders of pregnancy (HDP), the results were inconsistent. Furthermore, no studies have been conducted in China where the ambient O concentration continuedly increased. The present study aimed to estimate the effects of maternal exposure to O during pregnancy on the HDP risk, systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP).

An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.

Liver cell death has an essential role in nonalcoholic steatohepatitis (NASH). The activity of the energy sensor adenosine monophosphate (AMP)-activated protein kinase (AMPK) is repressed in NASH. Liver-specific AMPK knockout aggravated liver damage in mouse NASH models.

A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis.

Pathological activation of TGF-β signaling is universal in fibrosis. Aberrant TGF-β signaling in conjunction with transdifferentiation of hepatic stellate cells (HSCs) into fibrogenic myofibroblasts plays a central role in liver fibrosis. Here we report that the DNA demethylase TET3 is anomalously upregulated in fibrotic livers in both humans and mice.

Associations of rs2300782 , rs2292239 and rs10491034 with Diabetic Retinopathy Among Chinese Hui Population.

Diabetic retinopathy (DR) is considered a main cause for vision loss in diabetes. To our knowledge, there were no studies on the association of genetic variants with DR in Chinese Hui nationality. In our research, 34 single nucleotide polymorphisms (SNPs) that were reported to be associated with DR in other ethnics were genotyped in 123 subjects with DR and 12 subjects without DR among Chinese Hui population using MassARRAY system.

Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform.

Precise control of hepatic glucose production (HGP) is pivotal to maintain systemic glucose homeostasis. HNF4α functions to stimulate transcription of key gluconeogenic genes. HNF4α harbors two promoters (P2 and P1) thought to be primarily active in fetal and adult livers, respectively.

Fructose levels are elevated in women with polycystic ovary syndrome with obesity and hyperinsulinemia.

Study Question: Are fructose levels altered in women with polycystic ovary syndrome (PCOS)?

Summary Answer: Elevated serum fructose levels are associated with PCOS in Chinese Han women with overweight/obesity and hyperinsulinemia, and fructose levels are higher in follicular fluids from PCOS patients than from control subjects.

What Is Known Already: Both fructose levels and PCOS are closely linked to obesity and insulin resistance. However, the relationship between fructose and PCOS remains largely unknown.

Association of treRNA with lymphatic metastasis and poor prognosis in colorectal cancer.

Background: There is an emerging concept that long noncoding RNAs (lncRNAs) are involved in tumorigenesis and could be used as biomarkers. However, the clinical significance of human translational regulatory lncRNA (treRNA) in CRC is largely unknown. The purpose of the study was to examine the value of treRNA as a biomarker in colorectal cancer patients.

[Intestinal dysfunction of spinal cord injury treated with moxibustion: a randomized controlled trial].

Objective: To compare the clinical effect on intestinal dysfunction of spinal cord injury (SCI) between the comprehensive therapy of moxibustion (moxibustion for opening the governor vessel and regulating the spirit) and rehabilitation training and the simple treatment with rehabilitation training.

Methods: A total of 60 patients with intestinal dysfunction of SCI were randomized into a comprehensive therapy group and a rehabilitation group, 30 cases in each one (3 cases were dropped out in each group). On the base of the routine western medicine treatment and rehabilitation training, the bowel training and rectal function training were provided, once a day in the rehabilitation group.

HuR stabilizes mRNA via interacting with its exon 11 in a mutant HTT-dependent manner.

Huntington's Disease (HD) is a monogenetic neurodegenerative disorder mainly caused by the cytotoxicity of the mutant HTT protein (mHTT) encoded by the mutant gene. Lowering mRNA has been extensively studied as a potential therapeutic strategy, but how its level is regulated endogenously has been unclear. Here we report that the RNA-binding protein (RBP) HuR interacts with and stabilizes mRNA in an mHTT-dependent manner.

Small and lightweight laser retro-reflector arrays for lunar landers.

A set of small and lightweight laser retro-reflector arrays (LRAs) was fabricated and tested for use on lunar landers under NASA's Commercial Lunar Payload Service program. Each array contains eight 1.27-cm-diameter corner cube retro-reflectors mounted on a dome-shaped aluminum structure.

The long non-coding RNA HCG18 promotes the growth and invasion of colorectal cancer cells through sponging miR-1271 and upregulating MTDH/Wnt/β-catenin.

Long non-coding RNAs (lncRNAs) have recently emerged as key regulators of the occurrence and progression of various human cancers, including colorectal cancer. However, the regulatory mechanism of lncRNAs in the tumorigenesis of colorectal cancer remains poorly understood. In this study, we aimed to elucidate the potential role of lncRNA HCG18 in colorectal cancer.

Optimal regulation of N/P in horizontal sub-surface flow constructed wetland through quantitative phosphorus removal by steel slag fed.

High concentration of nitrogen and phosphorus and imbalance of N/P can lead to the formation of water and the malignant proliferation of toxic microalgae. This study put forward the advanced nutrient removal with the regulation of effluent N/P as the core in order to restrain the eutrophication and growth of poisonous algae. According to the preliminary study and review, the optimal N/P for non-toxic green algae was 50:1.

Cu- and Fe-Codoped Ni Porous Networks as an Active Electrocatalyst for Hydrogen Evolution in Alkaline Medium.

Highly active catalysts from the earth-abundant metals are essential to materialize the low-cost production of hydrogen through water splitting. Herein, nickel porous networks codoped with Cu and Fe prepared by thermal reduction of presynthesized Cu, Fe-codoped Ni(OH) nanowires are reported. The sample consists of nanoparticles of ∼80 nm, which form highly porous network clusters of ∼1 μm with a pore size of 10-100 nm.

Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis.

Oxidized phospholipids (OxPLs), which arise due to oxidative stress, are proinflammatory and proatherogenic, but their roles in non-alcoholic steatohepatitis (NASH) are unknown. Here, we show that OxPLs accumulate in human and mouse NASH. Using a transgenic mouse that expresses a functional single-chain variable fragment of E06, a natural antibody that neutralizes OxPLs, we demonstrate the causal role of OxPLs in NASH.

Associations of ambient temperature exposure during pregnancy with the risk of miscarriage and the modification effects of greenness in Guangdong, China.

Miscarriage is one of the commonest complications of pregnancy. Although previous studies suggested that environmental factors were important causes of miscarriage, evidence is still inadequate. Here, we examined the association of maternal exposure to temperature with the risk of miscarriage and further assessed the modifying effects of surrounding residential greenness.

Amorphous Fe-Ni-P-B-O Nanocages as Efficient Electrocatalysts for Oxygen Evolution Reaction.

Electrocatalysts are one of the most important parts for oxygen evolution reaction (OER) to overcome the sluggish kinetics. Herein, amorphous Fe-Ni-P-B-O (FNPBO) nanocages as efficient OER catalysts are synthesized by a simple low-cost and scalable method at room temperature. The samples are chemically stable, in clear contrast to reported unstable or even pyrophoric boride samples.

Elevated Serum Mannose Levels as a Marker of Polycystic Ovary Syndrome.

Recent reports have highlighted the role of monosaccharide biosynthesis in the pathogenesis of polycystic ovary syndrome (PCOS), suggesting that these processes may serve as a biomarker in PCOS. Mannose is the main monosaccharide for protein glycosylation in mammals; however, the correlation between mannose and PCOS remains largely unknown. A total of 132 Chinese Han women were recruited at Shengjing Hospital of China Medical University.

Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds.

Accumulation of mutant proteins is a major cause of many diseases (collectively called proteopathies), and lowering the level of these proteins can be useful for treatment of these diseases. We hypothesized that compounds that interact with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3) and the disease-causing protein may target the latter for autophagic clearance. Mutant huntingtin protein (mHTT) contains an expanded polyglutamine (polyQ) tract and causes Huntington's disease, an incurable neurodegenerative disorder.

Increased expression of TET3 predicts unfavorable prognosis in patients with ovarian cancer-a bioinformatics integrative analysis.

Ovarian carcinoma is a lethal gynecological malignancy. Women with ovarian cancer (OC) are highly recurrent and typically diagnosed at late stage. Ten-eleven translocation protein 3 (TET3) belongs to the family of ten-eleven translocations (TETs) which induce DNA demethylation and gene regulation in epigenetic level by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC).

Highly efficient antifogging and antibacterial food packaging film fabricated by novel quaternary ammonium chitosan composite.

In this work, a multifunctional food packaging composite coating with transparent, biodegradable, antifogging and antibacterial properties was designed and fabricated by quaternary ammonium salt modified chitosan (HACC) and poly (vinyl alcohol) (PVA) via a facile and environment-friendly solution casting method. A simple quaternization modification enabled the coating simultaneously to achieve excellent antifogging and antibacterial functions. The excellent antifogging property of the HACC/PVA composite coating was attributed to the strong water absorbency of quaternary ammonium chitosan and PVA.

Correlation of Blood FoxP3+ Regulatory T Cells and Disease Activity of Atopic Dermatitis.

Objectives: To investigate CD4+CD25+FoxP3+ T regulatory cells (Tregs) in the peripheral blood of patients with atopic dermatitis (AD) and its correlation with disease severity.

Methods: Blood samples from 79 AD patients before and after four-week conventional treatment were collected. Cell counts of CD4+CD25+FoxP3+Tregs, CD4+CD25+FoxP3-T effector cells (Teffs), and CD4+IL-10+Tregs were analyzed by flow cytometry.

A Network Pharmacology Approach to Explore the Mechanisms of Qishen Granules in Heart Failure.

This study aimed to investigate the intrinsic mechanisms of Qishen granules (QSG) in the treatment of HF, and to provide new evidence and insights for its clinical application. Information on QSG ingredients was collected from Traditional Chinese medicine systems pharmacology (TCMSP), TCM@Taiwan, TCMID, and Batman, and input into SwissTargetPrediction to identify the compound targets. HF-related targets were detected from Therapeutic Target Database (TTD), Disgenet-Gene, Drugbank database, and Online Mendelian Inheritance in Man (OMIM) database.

Reinforced Laryngeal Mask in Pediatric Laparoscopic Surgery.

Objective: To determine the frequency of reflux and aspiration in children subjected to reinforced laryngeal mask during laparoscopic surgery in the Trendelenburg position, and evaluate its feasibility.

Study Design: A descriptive study.

Place And Duration Of Study: Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, from January 2017 to May 2018.

Long Non-coding RNA LINC01420 Contributes to Pancreatic Cancer Progression Through Targeting KRAS Proto-oncogene.

Background: Long non-coding RNAs (lncRNAs) have been increasingly uncovered to participate in multiple human cancers, including pancreatic cancer (PC). However, the underlying mechanisms of most of the lncRNAs have not been fully understood yet.

Aims: In this study, we probed the role and latent mechanism of LINC01420 in PC.

Highly Efficient and Stable Hydrogen Production in All pH Range by Two-Dimensional Structured Metal-Doped Tungsten Semicarbides.

Transition-metal-doped tungsten semicarbide nanosheets (M-doped WC NSs, M=Fe, Co, and Ni) have been synthesized through carburization of the mixture of tungsten trioxide, polyvinylpyrrolidone, and metal dopant. The nanosheets grow directly on the W mesh and have the lateral dimension of several hundreds of nm to a few m with a thickness of few tens nm. It is demonstrated that the M-doped WC NSs exhibit superior electrocatalytic activity for hydrogen evolution reaction (HER).