Publications by authors named "Sun T"
Physical reservoir-based reservoir computing (RC) systems for intelligent perception have recently gained attention because they require fewer computing resources. However, the system remains limited in infrared (IR) machine vision, including materials and physical reservoir expression power. Inspired by biological visual perception systems, the study proposes a near-infrared (NIR) retinomorphic device that simultaneously perceives and encodes narrow IR spectral information (at ≈980 nm).
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- * In a study, CAP was found to induce ferroptosis, significantly reducing the growth and spread of squamous cell carcinoma cells.
- * The mechanism involves CAP generating reactive oxygen species (ROS) that damage DNA, activate specific cellular pathways, and decrease protective protein levels, leading to cell death and indicating CAP's potential in cancer therapy.
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- * The review examines recent advancements in the extraction, purification, and structural analysis of FPs, along with their bioactivities and relationships between structure and function.
- * Understanding the composition and characteristics of FPs, such as their monosaccharide makeup and molecular weight, is crucial for developing new bioactive compounds for health, food, and medical applications.
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- Polymyxins are being tested as a treatment for ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Gram-negative bacteria (CR-GNB) using different administration methods, especially focusing on intravenous combined with aerosolised delivery.
- A review analyzed 11 studies and found that combining intravenous and aerosolised polymyxins significantly reduced all-cause mortality and improved rates of clinical improvement and microbial eradication compared to using only intravenous polymyxins.
- However, there were no notable differences in clinical cure rates or nephrotoxicity between the two treatment methods, suggesting that aerosolised polymyxins could be a beneficial addition for patients with CR-GNB VAP.
Peptidyl arginine deiminase 4 (PAD4)-mediated neutrophil extracellular traps (NETs) play a crucial role in the pathogenesis of ulcerative colitis (UC). The cGAS-STING intracellular DNA-sensing pathway has been recognized as a pivotal mediator of inflammation. This study aimed to explore how NETs contribute to intestinal inflammation and barrier dysfunction in UC, focusing on the cGAS-STING pathway.
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- * Researchers analyzed data from two databases, employing multiple methods to assess causality and check for biases, revealing 28 metabolites that affect the risk of these conditions.
- * Among these metabolites, 8 decrease and 14 increase the risk of lower back pain or sciatica, while no reverse causal associations were found, and further analysis identified 11 significant metabolic pathways linked to the health conditions.
With the rapid development of science and technology, stealth and anti-corrosion activities in oceans have attracted widespread attention. This study successfully prepares CoFeO@SiO with a core-shell structure. This core-shell structure endows the CoFeO@SiO with good impedance matching and interfacial polarization.
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- - The MONARCH plus study found that adding abemaciclib to endocrine therapy significantly improved progression-free survival (PFS) and objective response rate (ORR) in postmenopausal women with HR+/HER2- advanced breast cancer.
- - In the study, cohort A (no prior systemic therapy) showed a median PFS of 28.27 months for abemaciclib users compared to 14.73 months for those on placebo, while cohort B (progression on prior therapy) showed 11.41 months vs. 5.59 months, respectively.
- - Although abemaciclib was associated with some adverse events, they were manageable, and it demonstrated a trend toward overall survival (OS
Background: Endovascular interventions for peripheral artery disease have increased in prevalence over time given the inherent benefits of minimally invasive approaches. Although it is essential that vascular surgery graduates are facile with endovascular techniques, the results of the BEST-CLI (Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia) trial highlight the equivalent importance of ensuring trainee competence in open skills.
View Article and Find Full Text PDFBackground And Purpose: The triglyceride-glucose (TyG) index, a novel reliable biomarker for IR that incorporates blood glucose and triglyceride, is linked to intracranial atherosclerotic stenosis (ICAS). In this study, we aimed to further investigate the association between the TyG index and the outcomes of ICAS patients following extracranial-to-intracranial (EC-IC) bypass grafting.
Methods: 489 ICAS patients who underwent EC-IC bypass between Jan 2009 and Jan 2022 at our hospital were retrospectively collected.
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- The research looked at using special viruses called bacteriophages to fight bacteria in development engineering stuff.
- They tested two types of bacteriophages (T4 and M13) with different cell setups to see if they could help with infections without harming the cells.
- The study found that these bacteriophages could stick to tiny particles and survive many tests, showing they can be a safe way to reduce bacterial contamination.
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- Pulmonary infections from respiratory syncytial virus (RSV) remain a significant health risk for infants and the elderly, and current treatments are limited to symptom management.
- This study investigates the potential of Leaf (FSL), which has shown anti-RSV properties, by evaluating its active components and mechanisms using a mouse model of RSV infection.
- Results indicate that the active component Phillyrin in FSL effectively reduces RSV replication and controls associated inflammatory responses, improving overall pathological conditions in infected mice.
Background: The phase 2 PERMEATE study has shown the antitumor activity and safety of pyrotinib plus capecitabine in patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer and brain metastases. In this report, survival results were updated with extended follow-up.
Methods: Between January 29, 2019 and July 10, 2020, adult patients with HER2-positive metastatic breast cancer who had radiotherapy-naïve brain metastases (cohort A, n = 59) or progressive disease after radiotherapy (cohort B, n = 19) were enrolled and received pyrotinib (400 mg once daily) and capecitabine (1000 mg/m twice daily on days 1-14 of each 21-day cycle) until disease progression or unacceptable toxicity.
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- Terahertz devices are crucial for terahertz technology but face challenges due to natural materials' poor response in the terahertz band, leading to limited performance.
- A new metamaterial device using vanadium dioxide (VO) has been developed, consisting of an Au layer, SiO layer, and VO layer, showing high reflective and absorptive capabilities at different temperatures.
- The study utilizes models to analyze phase transitions, conductivity, and absorption mechanisms, demonstrating that the device can be used effectively in applications like energy collection and electromagnetic stealth.
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- The study addresses the lack of understanding and research on essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (pre-PMF) in individuals under 18, calling attention to diagnostic and treatment issues.
- A large cohort analysis revealed immunophenotypic abnormalities as new clonal markers in childhood ET and pre-PMF, alongside unique mutational profiles compared to adults.
- Key findings show that venous thrombosis and specific immunophenotypic abnormalities are risk factors for disease progression, with significant differences in treatment practices and outcomes between childhood and adult cases.
Conventional welding methods encounter significant challenges, including poor weldability, low joint strength, and the formation of brittle intermetallic compounds, primarily due to the substantial disparities in the physical and chemical properties of aluminum and iron. To mitigate these issues, the vaporizing foil actuator welding (VFAW) process has emerged as a highly promising solid-phase welding technology, particularly suitable for joining dissimilar metals with pronounced differences in properties, such as aluminum alloys and stainless steels. The present study provides an innovative quantitative analysis of the interfacial impact energy conversion mechanisms within the VFAW process.
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- Bacterial zoonoses pose a significant threat to public health and the financial stability of societies, with limited options for diagnosis and treatment.*
- Mammalian miRNAs play crucial roles in managing bacterial infections by regulating gene expression through mechanisms like translational inhibition and degrading target genes.*
- Exogenous miRNAs from traditional Chinese medicine plants show promise as therapeutic agents, illustrating how plant-derived components can influence immune responses and bacterial disease management in mammals.*
Metamaterial absorbers show great potential in many scientific and technological applications by virtue of their sub-wavelength and easy-to-adjust structure, with bandwidth as an important standard to measure the performance of the absorbers. In this study, our team designed a new broadband absorber, which consists of an indium arsenide (InAs) disk at the top, a zinc selenide (ZnSe)-chromium (Cr) stacked disk in the middle and a metal film at the bottom. Simulation results show that the absorber has remarkable absorptivity properties in the mid-long infrared band.
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- Scientists used special data from a detector to look for rare particle decays of a type called the D_{s}^{+} decay, focusing on how it might change into other particles like kaons or pions.
- They found strong evidence for the decay D_{s}^{+}→π^{+}ϕ and also discovered a new decay D_{s}^{+}→ρ^{+}ϕ, both involving particles that decay into pairs of electrons.
- However, they didn't find strong signals for three other types of decays they were looking for, and set limits on how often those changes could happen.
Maternal inheritance of mitochondrial DNA (mtDNA) is a widespread phenomenon in eukaryotes. Our earlier research indicated that sperm mtDNA is removed prior to fertilization in mice, and Endonuclease G (ENDOG) orchestrates the degradation of sperm mitochondria in Caenorhabditis elegans. However, the mechanisms underlying sperm mtDNA disposal in mammals remain poorly understood.
View Article and Find Full Text PDFIntroduction: Breast cancer (BC) is a prevailing malignancy among women, and its inconspicuous development contributes significantly to mortality. The RNA N6-methyladenosine (mA) modification represents an emerging mechanism for gene expression regulation, with the active involvement of the YTH N6-methyladenosine RNA binding protein 3 (YTHDF3) in tumor progression across multiple cancer types. Nonetheless, its precise function in breast cancer necessitates further investigation.
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- - A new species from the genus Kükenthal, 1919 was discovered in shallow waters around the Nanji Islands in the East China Sea using a combination of morphological and molecular methods.
- - The new species is similar to one described by Williams & Vennam in 2001, but it has distinct differences in sclerite composition and colony color.
- - Molecular analysis indicated this new species belongs to a monophyletic group that includes other related species, showing a close evolutionary relationship with them.
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- Scientists found two new types of fungi living in the soil and feeding on certain caterpillars.
- One type has white structures and smooth oval spores, while the other is dark brown with different shaped cells and spores.
- They studied the DNA and mitochondrial genes of these fungi, learning that their gene lengths vary, which helps understand their diversity and relationships better.
Advances in the mechanism of CDK4/6 inhibitor resistance in HR+/HER2- breast cancer.
Ther Adv Med Oncol
September 2024
Among women, breast cancer is the most prevalent form of a malignant tumour. Among the subtypes of breast cancer, hormone receptor (HR) positive and human epidermal growth factor receptor (HER2) negative kinds make up the biggest proportion. The advent of cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors, which are dependent on cell cycle proteins, has greatly enhanced the prognosis of patients with advanced HR+/HER2- breast cancer.
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- Trastuzumab emtansine (T-DM1) is a targeted cancer therapy for HER2-positive breast cancer that effectively delivers a drug to tumor cells, but it can cause thrombocytopenia, leading to treatment discontinuation.
- A study explores using PLGA nanoparticles to carry T-DM1, which might reduce the side effects while maintaining its efficacy against tumors.
- The nanoparticle delivery system significantly decreases the negative impact on blood cell production and enhances the overall safety and effectiveness of T-DM1 for patients with HER2-positive breast cancer.