Publications by authors named "Sun Shin"
Objectives: The aim of this study was to evaluate the combined effect of dual-focus soft contact lenses (CLs) and 0.05% atropine in the control of myopia.
Methods: A retrospective study was conducted on 142 myopic children aged 7 to 13 years.
Article Synopsis
- The study investigates the relationship between preserved ratio impaired spirometry (PRISm) and mortality rates in individuals over 40 years old who underwent health screenings from 2003 to 2020.
- Participants were divided into three groups based on lung function: normal, PRISm with normal forced vital capacity (FVC), and PRISm with low FVC.
- Results show that individuals with PRISm, especially those with low FVC, have a significantly higher risk of death compared to those with normal lung function.
Article Synopsis
- * The study involved 1,526 COPD patients who began MVPA and 4,516 who did not, revealing significant decreases in future inhaled corticosteroid (ICS) usage (HR 0.83) and severe exacerbations (HR 0.81) for those who engaged in MVPA over a median follow-up of 3 years.
- * Results were consistent across various demographics, suggesting that adding MVPA to their treatment could enhance health outcomes for
Neoadjuvant chemotherapy combined with bevacizumab is used to treat colorectal cancer (CRC) patients by targeting tumor and vascular cells. However, it is known that other cells in the tumor microenvironment (TME) also change in response to this treatment. To investigate the changes in TME subpopulations in response to neoadjuvant FOLFOX6 plus bevacizumab, we studied pre- and post-treatment CRC tissues in four patients using single-cell RNA sequencing (scRNA-seq).
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- There is uncertainty about how long to monitor pure ground-glass nodules (pGGNs) found on low dose CT scans, and longer studies are needed to determine optimal follow-up times.
- This retrospective study analyzed 135 pGGNs in 89 patients over a median follow-up of 193 months, revealing that 17% increased in size, with some growing even after 10 years.
- The results indicate that among pGGNs stable for 10 years, 3.9% eventually grew, suggesting that a follow-up period longer than 10 years may be necessary to confirm the stability of these nodules.
Aim: This study was conducted to develop an electrocardiogram education program that incorporates an HTML webpage and blended learning methods to enhance electrocardiogram interpretation skills. Through continual and efficient education, the program aims to assist nurses in providing appropriate care and treatment to patients.
Design: Pre-post design study.
Objectives: This study was performed to investigate the detection rate of EGFR T790M mutation by repeated rebiopsy, to identify the clinical factors related to repeated rebiopsy, and to assess survival outcomes according to the methods and numbers of repeated rebiopsies in patients with lung adenocarcinoma who received sequential osimertinib after failure of previous 1st or 2nd generation EGFR-tyrosine kinase inhibitors.
Methods: This retrospective study included patients with advanced-stage lung adenocarcinoma who were confirmed to have EGFR T790M mutation and to have received osimertinib from January 2020 to February 2021 at Samsung Medical Center. The presence of T790M mutation was assessed based on either plasma circulating tumor DNA (ctDNA) or tissue specimens.
Background: The Global Initiative for Chronic Obstructive Lung Disease 2023 revision proposed that chronic obstructive pulmonary disease (COPD) has various etiologies including infections (COPD-I), such as tuberculosis and human immunodeficiency virus. While nontuberculous mycobacterial pulmonary disease (NTM-PD) and pulmonary tuberculosis share similar clinical manifestations, research on COPD development during longitudinal follow-up in patients with NTM-PD is limited. In this study, we aimed to evaluate the incidence and risk of COPD development in patients with NTM-PD.
View Article and Find Full Text PDFBackground: Whether the ratio of forced expiratory volume in 1 s to forced vital capacity (FEV/FVC) can be used as a biomarker to predict the risk of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is unclear.
Methods: To investigate the predictive role of FEV/FVC for AECOPD, we analyzed data from an observational and multicenter cohort study of 2043 patients with COPD in KOREA. Exposures were post-bronchodilator FEV/FVC and/or percentage predicted FEV (FEV%pred).
Article Synopsis
- There is limited knowledge on how emphysema and small airway disease impact the progression of COPD, even when analyzing data from two separate patient groups.
- Using chest CT scans, researchers divided COPD patients with low levels of emphysema (less than 10%) into two groups (low and high PRM) and looked for changes in emphysema over time.
- Results showed that patients with high PRM experienced more significant increases in emphysema compared to those with low PRM, suggesting that small airway disease might occur before emphysema in early COPD patients.
Article Synopsis
- * Researchers analyzed data from major databases and implemented sequencing techniques to identify 366 specific methylation markers for lung cancer detection.
- * They created a targeted sequencing panel that demonstrated an accuracy of 81.5% in distinguishing lung cancer from healthy samples, reaching impressive sensitivity levels in detecting cancer at low tumor fractions.
Background/aim: Although the importance of low-dose computed tomography (LDCT) screening is increasingly emphasized and implemented, many lung cancers continue to be incidentally detected during routine medical practices, and data on incidentally detected lung cancer (IDLC) remain scarce. This study aimed to investigate the clinical characteristics and prognosis of IDLCs by comparing them with screening-detected lung cancers (SDLCs).
Patients And Methods: In this retrospective study, subjects with cT1 (≤3 cm) pulmonary nodules detected on baseline computed tomography (CT), later pathologically confirmed as primary lung cancer in 2015, were included.
Introduction: Examining the equity of health care and financial burden in households of deceased individuals in urban and rural areas is crucial for understanding the risks to both national and individual household finances. However, there is a lack of research on catastrophic health expenditure (CHE) in these households, specifically in urban and rural contexts. This study aims to identify the ability to pay and equity of CHE for both households of deceased individuals in urban and in rural areas.
View Article and Find Full Text PDFBackground: Accelerated lung function decline is characteristic of COPD. However, the association between blood eosinophil counts and lung function decline, accounting for current smoking status, in young individuals without prevalent lung disease is not fully understood.
Methods: This is a cohort study of 629 784 Korean adults without COPD or a history of asthma at baseline who participated in health screening examinations including spirometry and differential white blood cell counts.
Purpose: To determine subjective symptoms and medical history of patients with intermittent exotropia in a large study population.
Methods: The Korean Intermittent Exotropia Multicenter Study (KIEMS) is a nationwide, observational, cross-sectional, multicenter study conducted by the Korean Association for Pediatric Ophthalmology and Strabismus including 5,385 patients with intermittent exotropia. Subjective symptoms and medical history of patients with intermittent exotropia were extracted by a comprehensive survey based on a self-administered questionnaire according to the study protocol of the KIEMS.
Article Synopsis
- - This study looks at how changes in body mass index (BMI) affect health outcomes in over 116,000 patients diagnosed with chronic obstructive pulmonary disease (COPD) between 2014 and 2019.
- - It found that significant BMI loss (>5%) was linked to a higher risk of all-cause mortality (1.70 times more likely) compared to those who maintained their BMI, while a small increase (>5%) in BMI also posed some risk (1.13 times more likely).
- - Overall, weight loss was particularly detrimental for underweight COPD patients, indicating that tracking BMI changes could be crucial for managing their health effectively.
Background: The effects of smoking reduction on the incidence of lung cancer in patients with chronic obstructive pulmonary disease (COPD) are not well known. This study aimed to investigate the effects of changes in smoking habits after COPD diagnosis on lung cancer development in patients who smoked less than 30 pack-years.
Methods: This nationwide retrospective cohort study included 16,832 patients with COPD who smoked less than 30 pack-years at the time of COPD diagnosis.
Article Synopsis
- Aerobic moderate-to-vigorous physical activity (MVPA), combined with resistance training (RT), may positively impact sleep and reduce respiratory symptoms in men with chronic obstructive pulmonary disease (COPD).
- A study analyzed data from over 61,000 individuals, focusing on 794 men with airflow limitations who engaged in MVPA, finding that those who also did RT reported fewer sleep problems, chronic cough, and sputum production.
- The benefits of adding RT to MVPA were more significant in men with a forced expiratory volume (FEV) of less than 80% of the predicted value, indicating a stronger effect on health for those with greater airflow limitations.
Many studies have demonstrated the mechanisms of progression to castration-resistant prostate cancer (CRPC) and novel strategies for its treatment. Despite these advances, the molecular mechanisms underlying the progression to CRPC remain unclear, and currently, no effective treatments for CRPC are available. Here, we characterized the key genes involved in CRPC progression to gain insight into potential therapeutic targets.
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- The study investigates the effectiveness of hypofractionated proton beam therapy (PBT) for early-stage lung cancer in patients who cannot undergo surgery, analyzing data from 27 patients diagnosed with inoperable non-small cell lung cancer (NSCLC).
- Results showed a 73.5% local control rate after two years, with better outcomes for smaller tumors, while about 48% of the patients experienced disease progression.
- The treatment was generally safe with minimal severe side effects, but quality of life issues like increased breathlessness were noted post-treatment, indicating room for improvement in managing symptoms.
Background: Fractional exhaled nitric oxide (FeNO) is known to useful biomarker for detecting eosinophilic airway inflammation. However, there is a lack of evidence regarding the role of FeNO in chronic obstructive pulmonary disease (COPD). We aimed to assess whether elevated FeNO and its impact on treatment change into an inhaled corticosteroid (ICS)-containing regimen and association with acute exacerbation (AE) in patients with COPD.
View Article and Find Full Text PDFBackground: Although PD-1 blockade is effective for treating several types of cancer, the efficacy of this agent in glioblastoma is largely limited. To overcome non-responders and the immunosuppressive tumor microenvironment, combinational immunotherapeutic strategies with anti-PD-1 need to be considered. Here, we developed IL-12-secreting mesenchymal stem cells (MSC_IL-12) with glioblastoma tropism and evaluated the therapeutic effects of anti-PD-1, MSC_IL-12, and their combination against glioblastoma.
View Article and Find Full Text PDFBackground: Patients with chronic obstructive pulmonary disease (COPD) have a high risk of developing lung cancer. Due to the high rates of complications from invasive diagnostic procedures in this population, detecting circulating tumor DNA (ctDNA) as a non-invasive method might be useful. However, clinical characteristics that are predictive of ctDNA mutation detection remain incompletely understood.
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- Lung cancer diagnostic guidelines recommend invasive mediastinal nodal staging (IMNS), but its effectiveness on survival in non-small cell lung cancer (NSCLC) patients without lymph node metastasis (rN0) remains unclear.
- A study compared long-term survival rates between NSCLC patients who underwent IMNS and those who did not, using data from the Samsung Medical Centre from 2008 to 2016.
- Results showed no significant survival difference; both groups had similar 5-year overall survival rates (73.9% for IMNS vs. 71.7% for non-IMNS) and recurrence-free survival rates, despite a 7.2% incidence of unexpected metastasis in the IMNS group.
Article Synopsis
- Preserved ratio impaired spirometry (PRISm) is linked to higher risk of cardiovascular disease (CVD) and mortality, but its direct causal relationship with CVD isn't fully established.
- A study examined 11,420 participants aged 40 and older, assessing their coronary artery calcium (CAC) scores based on the presence of PRISm and reduced forced vital capacity (FVC).
- Results showed that participants with PRISm experienced a significant increase in CAC progression over five years, especially pronounced in those with low FVC.