Synergistic effects of fluid shear stress and adhesion morphology on the apoptosis and osteogenesis of mesenchymal stem cells.

Mechanical microenvironments, such as characteristics defining mechanical environments and fluid flow play an important role in steering the fate of mesenchymal stem cells (MSCs). However, the synergistic effect of adhesion morphology and fluid flow on the biological behavior of MSCs is seldom investigated. In this article, 0.

ILF2 Contributes to Hyperproliferation of Keratinocytes and Skin Inflammation in a KLHDC7B-DT-Dependent Manner in Psoriasis.

The extensive involvement of interleukin enhancer binding factor 2 (ILF2) in RNA stability and the inflammatory response is well documented. Aberrant long noncoding RNA (lncRNA) expression contributes to the pathogenesis of psoriasis. However, little is known about the role of ILF2 in psoriasis.

Fabrication of Janus-type nanocomposites from cellulose nanocrystals for self-healing hydrogels' flexible sensors.

Janus bio-nanomaterials have great application potential in functional solid surfactants, probes and flexible sensors. In this manuscript, the sustainable Janus cellulose nanocrystals-type (CNCs-type) nanomaterials were prepared by Pickering emulsion template method. The asymmetric functionalism of Janus nanorods was realized by asymmetrically grafting polypyrrole (PPy) and polydopamine (PDA) onto different sides of CNCs (Janus CNCs-PPy /PDA (JCNs)).

The Regulation of Lymph Node Pre-Metastatic Niche Formation in Head and Neck Squamous Cell Carcinoma.

In many distinct forms of malignancies, there is a close relationship between lymph node (LN) metastases and further dissemination to distant organs, and this is a critical prognostic factor. At the beginning of the process, the original tumor secretes soluble substances or releases extracellular vesicles (EVs) that are carried through lymphatic channels to draining (sentinel) LN. The tumor-derived factors then drive LN remodeling.

Construction of an individualized clinical prognostic index based on ubiquitination-associated lncRNA in clear cell renal cell carcinoma patients.

Background: ccRCC is considered as the main subtype of RCC, which accounted for sixth deadliest cancer worldwide. Recently, ubiquitination has been reported to be closely involved in the progression of tumore. The purpose of this study was to identify the ubiquitination-associated genes and co-expressed lncRNAs on the prognosis of clear cell renal cell carcinoma (ccRCC) patients.

Efficient degradation of antibiotics over Co(II)-doped BiMoO nanohybrid via the synergy of peroxymonosulfate activation and photocatalytic reaction under visible irradiation.

Developing efficient photocatalysts based on the peroxymonosulfate (PMS) activation for effective degradation of threatening antibiotic contamination under visible light is still a challenging subject. Herein, a Co-doped BiMoO (CBMO) spherical crystals were synthesized via a facile hydrothermal method and used to degrade artificial antibiotic wastewater via PMS activation under visible light. The obtained 3 wt% Co-doped BMoO (3CBMO) can effectively remove 98.

Analysis and Comparison of Gut Microbiome in Young Detection Dogs.

The detection dogs are well-known for their excellent capabilities to sense different kinds of smells, which can play an important role in completing various searching and rescuing missions. The recent studies have demonstrated that the excellent olfactory function of detection dogs might be related with the gut microbes the bidirectional communications between the gastrointestinal tract and the brain. In this study, the gut microbial communities of three types of breeds of detection dogs (Springer Spaniel, Labrador Retriever, and German Shepherd) were studied and compared.

Role of raising domestic animals in decreasing the risk of dementia occurrence in Chinese older adults: Evidence of a 10-year prospective cohort study.

This study explored the causal relationship between raising domestic animals and the risk of dementia occurrence. A 10-year cohort study was carried out drawing the data from Chinese Longitudinal Health Longevity Survey (CLHLS) 2008-2018. The Cox regression model was applied to analyze the association between raising domestic animals and the risk of developing dementia.

Surface modification of phosphogypsum and application in polyolefin composites.

Phosphogypsum (PG) is one of solid wastes with large amount of yield and serious pollution, which has attracted wide attention. The aim of this study is to investigate filling performance of PG on polypropylene (PP) or high-density polyethylene (HDPE) matrix. In this work, PG was calcined initially to improve whiteness and fix impurities.

Metabolic characterization of hypertrophic cardiomyopathy in human heart.

Hypertrophic cardiomyopathy (HCM) is a common inherited cardiovascular disease with heterogeneous clinical presentations, governed by multiple molecular mechanisms. Metabolic perturbations underlie most cardiovascular diseases; however, the metabolic alterations and their function in HCM are unknown. Here, we describe the metabolome and lipidome of heart and plasma samples from individuals with and without HCM.

Extremely high levels of central nervous system involvement in miliary tuberculosis.

Background: Miliary tuberculosis (TB) is one of the severest manifestations of TB that can be lethal when concomitant with the central nervous system (CNS) involvement. Bacteriological, biochemical and radiological methods for find CNS comorbidity in miliary TB was evaluated in this study.

Methods: Consecutive miliary TB adults were retrospectively enrolled from two designated TB hospitals in China.

Finite element analysis on mechanical state on the osteoclasts under gradient fluid shear stress.

Mechanical loading, such as fluid shear stress (FSS), is regarded as the main factor that regulates the biological responses of bone cells. Our previous studies have demonstrated that the RAW264.7 osteoclast precursors migrate toward the low-FSS region under the gradient FSS field by a cone-and-plate flow chamber, in which the FSS in the outer region is larger than that in the inner region along the radial direction.

Rapid Differential Detection of Japanese Encephalitis Virus and Getah Virus in Pigs or Mosquitos by a Duplex TaqMan Real-Time RT-PCR Assay.

Both JEV (Japanese encephalitis virus) and GETV (Getah virus) pose huge threats to the safety of animals and public health. Pigs and mosquitoes play a primary role in JEV and GETV transmission. However, there is no way to quickly distinguish between JEV and GETV.

Visible Light-Driven Selective Reduction of CO by Acetylene-Bridged Cobalt Porphyrin Conjugated Polymers.

Photocatalytic conversion of CO into renewable fuels with high efficiency and selectivity is desirable for solar energy utilization, but remains a great challenge. Herein, cobalt(II)-porphyrin functionalized conjugated polymers with acetylene bridging units, assembled through the Sonogashira cross coupling reaction, as heterogeneous catalysts for CO photoreduction were presented. Experimental investigations and density functional theory calculations demonstrated the crucial roles of Co centers in porphyrin units for CO activation and conversion, while excessive acetylene group prompted the competing hydrogen evolution reaction and reduced the selectivity.

Long-term neurological outcomes of children with neuroblastoma with opsoclonus-myoclonus syndrome.

Background: Neuroblastoma with opsoclonus-myoclonus syndrome (OMS-NB) is a rare disease in children. Few studies of long-term outcome of children with OMS-NB were conducted. This study aimed to review the rate of recovery of neurological symptoms and the long-term neurological outcomes of children with OMS-NB.

A nomogram to assist blastocyst selection in vitrified-warmed embryo transfer cycles.

Aim: The purpose of the study was to establish a mathematical model to help rank the order of blastocysts and assist selection of which blastocysts to warm in vitrified-thawed embryo transfer cycles.

Design: A total of 2862 women who underwent first vitrified-thawed single blastocyst transfer (SBT) between July 2015 and July 2019 were retrospectively recruited and randomized into a training set (n = 2289) and testing set (n = 573). Least absolute shrinkage and selection operator (LASSO) regression was used to screen the factors critical to live birth (LB).

Dynamic changes of macrophage activation in mice infected with Trichinella spiralis.

Trichinellosis is a serious food-borne parasitic zoonosis worldwide. Different host macrophage subsets play various roles during helminth infection; however, the dynamic changes in macrophage subsets following Trichinella spiralis infection have not been reported. Here, flow cytometry and immunofluorescence were used to assess macrophage activation in mesenteric lymph nodes (MLN), spleen, intestine, and muscle from T.

Functional carbon nanodots improve soil quality and tomato tolerance in saline-alkali soils.

High salinity and alkalinity of saline-alkali soil lead to soil deterioration, the subsequent osmotic stress and ion toxicity inhibited crops growth and productivity. In this research, 8 mg kg and 16 mg kg functional carbon nanodots (FCNs) can alleviate the adverse effects of saline-alkali on tomato plant at both seedling and harvest stages, thanks to their up-regulation effects on soil properties and plant physiological processes. On one hand, FCNs stimulate the plant potential of tolerance to saline-alkali and disease resistance through triggering the defense response of antioxidant system, enhancing the osmotic adjustment, promoting the nutrient uptake, transportation and utilization, and up-regulating the photosynthesis, thereby improve tomato growth and productivity in saline-alkali soils.

CircOAS3 Regulates Keratinocyte Proliferation and Psoriatic Inflammation by Interacting with Hsc70 via the JNK/STAT3/NF-κB Signaling Pathway.

Psoriasis is a chronic inflammatory disease of the skin with a very complex pathogenesis. Circular RNAs (circRNAs) play important regulatory roles in many diseases, including psoriasis. In this study, we found that circOAS3 expression was significantly upregulated in both psoriatic tissues and M5-induced keratinocytes.

Enhancing S-nitrosoglutathione reductase decreases S-nitrosylation of Drp1 and reduces neuronal apoptosis in experimental subarachnoid hemorrhage both in vivo and in vitro.

Subarachnoid hemorrhage (SAH) is a hemorrhagic stroke with a high mortality and disability rate. Nitric oxide (NO) can promote blood supply through vasodilation, leading to protein S-nitrosylation. However, the function of S-nitrosylation in neurons after SAH remains unclear.

Focusing on the Subsequent Coulombic Efficiencies of SiO: Initial High-Temperature Charge after Over-Capacity Prelithiation for High-Efficiency SiO-Based Full-Cell Battery.

SiO-based anode materials are considered to be promising and have been gradually commercialized due to their high specific capacity as well as the acceptable volume change during lithiation/delithiation and preferable cycling stability compared to that of Si. Nevertheless, their inherently low Coulombic efficiency hinders the large-scale application. Up to now, researchers have paid much attention to the initial Coulombic efficiency and developed a series of effective prelithiation strategies.

CircEIF5 contributes to hyperproliferation and inflammation of keratinocytes in psoriasis via p-NFκB and p-STAT3 signalling pathway.

Psoriasis is a chronic, immune-mediated skin disease accompanied by hyperproliferation and inflammation of keratinocytes. Circular RNAs (circRNAs) as new players regulating the development of psoriasis have been reported in recent years. However, its mechanism has not yet been fully revealed.

Upcycling Waste Pine nut Shell Membrane for Highly Efficient Separation of Crude Oil-in-Water Emulsion.

Discharge of oily sewage and frequent oil spills have caused serious harm to human production, life, and ecological environment. Due to the presence of a large number of surfactants in water, these oil-water mixtures are easy to form oil-in-water emulsion, which is difficult to separate by traditional methods. At the same time, the water-soluble pollutants such as dyes and heavy metal ions in oily wastewater also cause great harm to the human body and the environment.

Targeting the Pulmonary Microbiota to Fight against Respiratory Diseases.

The mucosal immune system of the respiratory tract possesses an effective "defense barrier" against the invading pathogenic microorganisms; therefore, the lungs of healthy organisms are considered to be sterile for a long time according to the strong pathogens-eliminating ability. The emergence of next-generation sequencing technology has accelerated the studies about the microbial communities and immune regulating functions of lung microbiota during the past two decades. The acquisition and maturation of respiratory microbiota during childhood are mainly determined by the birth mode, diet structure, environmental exposure and antibiotic usage.

Financial inclusion and its influence on renewable energy consumption-environmental performance: the role of ICTs in China.

Financial inclusion means that individuals and businesses can easily avail financial goods and services at an affordable cost. It is widely recognized that financial inclusion can help preserve the environment by increasing the consumption of renewable energy sources. Hence, our basic aim is to investigate whether financial inclusion has any effect on renewable energy consumption and environmental quality in China.