The treatment of bone defects remains a great clinical challenge. With the development of science and technology, bone tissue engineering technology has emerged, which can mimic the structure and function of natural bone tissues and create solutions for repairing or replacing human bone tissues based on biocompatible materials, cells and bioactive factors. Hydrogels are favoured by researchers due to their high water content, degradability and good biocompatibility.
View Article and Find Full Text PDFDuring ovary development, the dormant primordial follicles (PF) are stimulated and begin to develop into primary follicles (PrF), a process called follicle activation. Only activated follicles can continue to grow and release the eggs in the future, making the female animal fertile. The molecular events during PF activation are not fully understood.
View Article and Find Full Text PDFJ Fungi (Basel)
November 2024
species are known to produce various secondary metabolites with polyketide structures, including Monacolins, pigments, and citrinin. This study investigates the effects of 5-azacytidine on M1 and RP2. The dry weight, red, yellow, and orange pigment values, and Monacolin K yield of both strains were measured, and their hyphae observed through electron microscopy.
View Article and Find Full Text PDFRecently, halide perovskites have been recognized for their thermochromic characteristics, showing significant potential in information encryption applications. However, the limited luminescence color gamut hinders the encryption of complex multicolor information. Herein, for the first time, multicolor thermochromic perovskites with luminescence covering the entire visible spectrum have been designed.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
Liver metastasis is the primary factor contributing to unfavorable prognosis in colorectal cancer (CRC). Although N-glycosylation is implicated in metastasis, there is a notable paucity of comprehensive studies addressing the N-glycosylation proteomics associated with liver metastasis in CRC. In this study, N-glycosylated proteins and N-glycosylation sites of differential expression between primary lesions and paired liver metastatic lesions are identified.
View Article and Find Full Text PDFTo investigate the impact of preoperative serum follicle-stimulating hormone (FSH) levels on the probability of testicular sperm retrieval, we conducted a study of nonobstructive azoospermic (NOA) men with different testicular volumes (TVs) who underwent microdissection testicular sperm extraction (micro-TESE). A total of 177 NOA patients undergoing micro-TESE for the first time from April 2019 to November 2022 in Shenzhen Zhongshan Obstetrics and Gynecology Hospital (formerly Shenzhen Zhongshan Urology Hospital, Shenzhen, China) were retrospectively reviewed. The subjects were divided into four groups based on average TV quartiles.
View Article and Find Full Text PDFPolynuclear Au(I) cluster photocatalysts, known for their high activity and stability, hold substantial potential in organic synthetic chemistry. This study synthesized two Au(I) supramolecular cluster catalysts with different nuclearities: a tetranuclear cluster, C1 ([(dppmAu2)2L1]•PF6-), and a hexadecanuclear cluster, C2 [(dppmAu2)6(Au4)(L1)4]•4PF6-, through a multicomponent stepwise self-assembly approach. Both cluster structures feature aurophilicity interaction motifs that endow them with exceptional photocatalytic performance, exhibiting optical band gaps of 2.
View Article and Find Full Text PDFThe purine metabolism is crucial for cellular function and is a conserved metabolic network from prokaryotes to humans. While extensively studied in microorganisms like yeast and bacteria, the impact of perturbing dietary intermediates from the purine biosynthesis on animal development and growth remains poorly understood. We utilized Caenorhabditis elegans as the metazoan model to investigate the mechanisms underlying this deficiency.
View Article and Find Full Text PDFBackground: Acute kidney injury (AKI) is common in patients with community-acquired pneumonia (CAP) and is associated with increased morbidity and mortality.
Objective: This study aimed to establish and validate predictive models for AKI in hospitalized patients with CAP based on machine learning algorithms.
Methods: We trained and externally validated 5 machine learning algorithms, including logistic regression, support vector machine, random forest, extreme gradient boosting, and deep forest (DF).
Ischemic stroke represents a highly perilous cerebrovascular disorder, involving a variety of complex pathophysiological mechanisms. OIP5 antisense RNA 1 (OIP5-AS1) is a long non-coding RNA (LncRNA) that has been shown to play a pivotal role in a variety of disease systems. However, there are relatively few studies on ischemic stroke.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
December 2024
Lithium-sulfur batteries (LSBs) are among the most promising next-generation energy storage technologies. However, a slow Li-S reaction kinetics at the LSB cathode limit their energy and power densities. To address these challenges, this study introduces an anionic-doped transition metal chalcogenide as an effective catalyst to accelerate the Li-S reaction.
View Article and Find Full Text PDFObjective: To investigate whether anti-centromere antibody (ACA) is associated with embryonic development and clinical outcomes in patients undergoing IVF/ICSI treatment.
Materials And Methods: Women who underwent fresh or frozen embryo transfer cycles at a reproductive center between January 1, 2017 and January 1, 2023, were retrospectively studied. Women were divided into ACA- group and ACA+ group according to ACA levels.
After recovering from COVID-19, many patients experience "long COVID" symptoms. Existing research has predominantly focused on moderate to severe cases, with limited studies examining mild cases and recurrent infections. The circulating low-molecular-weight (LMW) peptidome, involving lipid metabolism, coagulation, and immune pathways, is crucial for understanding COVID-19's long-term effects.
View Article and Find Full Text PDFOsteoarticular degeneration (OAD) is an important issue. Excessive fluoride can damage osteoarticular health. Besides, personal susceptibility (including genetic factors, physiological characteristics, and lifestyle) also contributes to osteoarticular development significantly.
View Article and Find Full Text PDF() is an important zoonotic pathogen which induces both acute and chronic toxoplasmosis. Timely diagnosis of is crucial for effective disease management. Here, we present a pioneering approach using europium (III)-chelated nanoparticles (EuNPs) in a rapid lateral flow immunochromatographic test strip (ICTS) for detecting antibodies in serum samples.
View Article and Find Full Text PDFThin endometrium (TE) has been widely recognized as a critical cause of infertility. However, the pathogenesis of TE remains unclear, and satisfactory treatment options are still urgently needed. Several animal models of TE have been developed, but the mouse model involving abdominal surgery and injection of 95% ethanol presents a formidable challenge due to the high mortality rate and risk of intrauterine adhesions if not performed correctly.
View Article and Find Full Text PDFCell Biol Toxicol
November 2024
Background: The present study investigated the function of G protein-coupled receptor kinase 2 (GRK2) in acute liver injury (ALI) by cisplatin, and investigated the protective effect of pharmacological inhibition of GRK2.
Methods: ALI models were generated in global adult hemizygous (ALI-Grk2) mice and wild-type (WT) mice. Liver biochemistry parameters and histopathology were used to evaluate the severity of ALI and the protective effect of pharmacological inhibition of GRK2.
Background: Target identification and hit identification can be transformed through the application of biomedical knowledge analysis, AI-driven virtual screening and robotic cloud lab systems. However there are few prospective studies that evaluate the efficacy of such integrated approaches.
Results: We synergistically integrate our in-house-developed target evaluation (SpectraView) and deep-learning-driven virtual screening (HydraScreen) tools with an automated robotic cloud lab designed explicitly for ultra-high-throughput screening, enabling us to validate these platforms experimentally.
To establish a predictive model for clinical pregnancy outcomes following the transfer of a single fresh blastocyst in vitro fertilization (IVF). 615 patients (492 in training set and 123 in test set) who underwent the first single and fresh blastocyst transfer in the first IVF or intracytoplasmic sperm injection cycle performed in fertility centre of Shenzhen Zhongshan Obstetrics & Gynecology Hospital from July 2015 to June 2021 were enrolled in this study. Conventional method such as logistic regression (LR), individual machine learning methods including naive bayesian (NB), K-nearest neighbours (K-NN), support vector machine (SVM), decision tree (DT), and ensemble learning methods including random forest (RF), XGBoost, LightGBM, Voting were used to establish the clinical pregnancy outcome prediction model, and the efficacy among different models was compared.
View Article and Find Full Text PDFObjective: to investigate the clinical value of vitamin K testing in children with vitamin D deficiency rickets. Methods: fifty children with vitamin D deficiency rickets admitted to our hospital from March 2021 to March 2022 were recruited as the case group using convenience sampling; and an additional 50 children without bone health diseases during the same period of health checkup were selected as the control group. The relevant indexes between the two groups were compared.
View Article and Find Full Text PDFThe electron transfer process (ETP) is able to avoid the redox cycling of catalysts by capturing electrons from contaminants directly. However, the ETP usually leads to the formation of oligomers and the reduction of oxidants to anions. Herein, the charge-confined Fe single-atom catalyst (Fe/SCN) with Fe-NS configuration was designed to achieve ETP-mediated contaminant activation of the oxidant by limiting the number of electrons gained by the oxidant to generate O.
View Article and Find Full Text PDFBiomed Pharmacother
November 2024
Autoimmune diseases encompass over 80 distinct types, affecting approximately 7.6-9.4 % of the population globally.
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