Pervasive RNA-binding protein enrichment on TAD boundaries regulates TAD organization.

Mammalian genome is hierarchically organized by CTCF and cohesin through loop extrusion mechanism to facilitate the organization of topologically associating domains (TADs). Mounting evidence suggests additional factors/mechanisms exist to orchestrate TAD formation and maintenance. In this study, we investigate the potential role of RNA-binding proteins (RBPs) in TAD organization.

Disorder-order transition-induced unusual bandgap bowing effect of tin-lead mixed perovskites.

Owing to the predominant merit of tunable bandgaps, tin-lead mixed perovskites have shown great potentials in realizing near-infrared optoelectronics and are receiving increasing attention. However, despite the merit, there is still a lack of fundamental understanding of the bandgap variation as a function of Sn/Pb ratio, mainly because the films are easy to segregate in terms of both composition and phase. Here, we report a fully stoichiometric synthesis of monocrystalline FAPbSnI nanocrystals as well as their atomic-scale imaging.

Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

Design of an Active-Passive Composite Impedance Controller for a Soft Robotic Arm Under Contact Constraints.

The inherent passive impedance characteristics of soft robotic arms provide excellent environmental adaptability. When a soft robotic arm interacts with its surroundings, its passive impedance responds swiftly, preventing rigid collisions that could damage the arm and ensuring high safety. However, during the movement of the soft robotic arm, these passive impedance properties are uncontrollable, making it impossible to achieve precise impedance control in constrained environments by relying solely on passive mechanisms.

Unraveling EEG correlates of unimanual finger movements: insights from non-repetitive flexion and extension tasks.

Background: The loss of finger control in individuals with neuromuscular disorders significantly impacts their quality of life. Electroencephalography (EEG)-based brain-computer interfaces that actuate neuroprostheses directly via decoded motor intentions can help restore lost finger mobility. However, the extent to which finger movements exhibit distinct and decodable EEG correlates remains unresolved.

Piezoelectric hydrogels for accelerating healing of diverse wound types.

The skin, as the body's largest organ, plays a crucial role in protecting against mechanical forces and infections, maintaining fluid balance, and regulating body temperature. Therefore, skin wounds can significantly threaten human health and cause a heavy economic burden on society. Recently, bioelectric fields and electrical stimulation (ES) have been recognized as a promising pathway for modulating tissue engineering and regeneration of wounded skin.

Full Mouth Rehabilitation for a Patient with Angle's Class II Division 2 Associated Deep Overbite and Worn Dentition - Case Report With 2-Year Follow-Up and Literature Review.

Some of the critical clinical challenges encountered in the treatment of adult patients with deep overbite and worn dentition include correction of deep overbite, establishment of an appropriate occlusal vertical dimension (OVD), and maintenance of long-term occlusal stability. Although Angle's Class II division 2-associated deep anterior overbite is common in orthodontic treatment, simple prosthodontic treatment with great improvement of deep anterior overbite and worn dentition is infrequently reported. A 51-year-old man with Class II Division 2 malocclusion presented with hypo-divergent facial pattern, reduced lower facial height, and protuberant lips.

Defect Detection and 3D Reconstruction of Complex Urban Underground Pipeline Scenes for Sewer Robots.

Detecting defects in complex urban sewer scenes is crucial for urban underground structure health monitoring. However, most image-based sewer defect detection models are complex, have high resource consumption, and fail to provide detailed damage information. To increase defect detection efficiency, visualize pipelines, and enable deployment on edge devices, this paper proposes a computer vision-based robotic defect detection framework for sewers.

Discordance in biomarker expression between primary breast cancers and loco-regional recurrences: a comprehensive analysis of 112 cases.

Background: Breast cancer is a complex disease encompassing multiple phenotypic and genetic subtypes. The biomarker status of primary and recurrent lesions may be dissimilar, and changes in biomarker status may inform clinical decision-making. The expression of biomarkers between primary breast cancers and loco-regional recurrences lacked large sample studies.

HER2-Targeted Affibody Molecule 99mTc-ABH2 for Imaging HER2 Expression in Breast Cancer.

Purpose: Accuracy in in vivo assessment of human epidermal growth factor receptor type 2 (HER2) status is crucial for predicting the response to HER2-targeted therapies in breast cancer. This study assessed the safety, feasibility, and diagnostic accuracy of 99mTc-ABH2, a reengineered affibody molecule with radionuclide labeling, for HER2 expression in breast cancer using SPECT/CT imaging, compared with 18F-FDG PET/CT.

Patients And Methods: Thirty-six patients suspected of primary breast cancer were enrolled in this prospective, single-center study from March to July in 2023.

Association of psoriasis disease with physical activity and exercise: systematic review and meta-analysis.

Introduction: Psoriasis (Pso) is an inflammatory autoimmune skin disease. High BMI, and elevated body fat and body weight is associated with risk of Pso development. People with Pso have lower physical activity than people without Pso, so they are at higher risk for comorbidities and underlying disease.

T2-LiCoO: A Durable, High-Capacity, High-Rate Cathode Material for Lithium-Ion Batteries.

Efficient utilization of resources is crucial for the sustainable development of the lithium-ion battery industry. Although the traditional R m space group LiCoO can provide a current advanced discharge capacity of 215-220 mAh g⁻¹ at an upper cut-off voltage of 4.6 V (relative to Li⁺/Li), it still falls far short of its theoretical specific capacity of 273 mAh g⁻¹, and exhibits structural instability and labile oxygen loss, leading to rapid capacity degradation.

pH-responsive hydrogel with gambogic acid and calcium nanowires for promoting mitochondrial apoptosis in osteosarcoma.

Calcium (Ca) overload therapy gained significant attention in oncology. However, its therapeutic efficacy remained limited due to insufficient Ca accumulation at the tumor site and suboptimal intracellular Ca influx. In this study, gambogic acid (GA), a natural phenolic compound known to promote Ca influx, was encapsulated within an enzyme-triggered, pH-responsive hydrogel (GM@Lip@CHP-Gel) containing Ca hydrogen phosphate nanowires (CHP) to achieve a synergistic approach for bone tumor therapy.

Unconventional Thermal Rectification in Assemblies of Supertetrahedral T-Type SnInSe Clusters.

Going beyond the conventional design paradigm with atoms as building blocks, we propose the concept of cluster-assembled thermal rectifiers comprising metal chalcogenide supertetrahedral clusters. Different from the experimentally reported T and T, for the first time we assemble T-SnInSe clusters into a stable T framework without needing extra ions, based on which the thermal rectification (TR) effect is explored using machine-learning molecular dynamics and the mode-resolved phonon Boltzmann transport equation. The tetrahedron-shaped cluster assembly serves as a novel TR switch, where the open state shows an outstanding TR efficiency (∼40%) arising from the asymmetric lateral confinement due to not only the phonon particle behavior but also the phonon wave nature.

Using SiO-Supported MnO@FeO Composite to Catalytically Decompose Waste Drilling Fluids Through Fenton-like Oxidation.

Waste drilling fluids produced from oil extraction can cause serious harm to the ecological environment; thus, the treatment of waste drilling fluids is urgent and important to ensure the sustainability and development of the oil extraction. In this work, we used the Fenton-like reaction method to degrade waste drilling fluids with SiO-supported MnO@FeO composite material as a catalyst in the presence of HO. During the Fenton-like reaction process, the MnO@FeO interface exhibits exceptional activity by facilitating the production of ·OH species with high activity and strong oxidizing properties, which degrade the organic substances in the waste drilling fluids into smaller inorganic molecules, thereby reducing its COD value.

The role of ferritinophagy and ferroptosis in Alzheimer's disease.

Iron is a crucial mineral element within human cells, serving as a pivotal cofactor for diverse biological enzymes. Ferritin plays a crucial role in maintaining iron homeostasis within the body through its ability to sequester and release iron. Ferritinophagy is a selective autophagic process in cells that specifically facilitates the degradation of ferritin and subsequent release of free iron, thereby regulating intracellular iron homeostasis.

Local Recurrence and Survival Outcomes of Multifocal/Multicentric Breast Cancer After Breast Conserving Therapy: A systematic Review and Meta-Analysis.

Background: The appropriateness of BCT for MF/MCBC is debated, with concerns about higher recurrence rates. This study aims to provide an updated systematic review and meta-analysis of LR and survival outcomes for MF/MCBC patients undergoing BCT.

Methods: PubMed, Web of Science, Embase, and the Cochrane Library were searched up to May 2024.

Cage-Based 3D Tetrahexagonal Boron Nitride Crystal with Excellent Terahertz Light Absorption.

In recent findings, a new classification of 1D and 2D tetrahexagonal boron nitrides (-BN) consisting of square and hexagonal rings has been documented. These materials exhibit impressive properties such as the tunable band gap, strong optical absorption, suitable sign-tunable Poisson's ratio, and high ideal strength, making them promising for applications in nano- and opto-electronic industries. Stimulated by these studies, we have designed a cage-based three-dimensional tetrahexagonal boron nitride (3D -BN) structure, which demonstrates excellent thermal, dynamic, and mechanical stability, including exceptional cohesive and formation energies of 6.

Effect of temperature on the radon release characteristics of red clay.

Bricks and tiles crafted from fired red clay are extensively utilized in everyday construction activities. However, red clay inherently contains radon gas, a radioactive substance that could potentially endanger human health. Hence, investigating the radon emission patterns of red clay post high-temperature treatment holds significant importance.

Polyethylene microplastic pollution changes the electrical resistance and thermal conductivity of loess soil.

While plastics provide convenience, they also endanger the safety of the natural environment. Microplastic pollution caused by plastic aging has become an urgent concern in public places. In order to study the effects of microplastics on soil physical properties, the electrical resistance and thermal conductivity of soils containing different polyethylene and moisture content were tested.

Screening Na-Excess Cation-Disordered Rocksalt Cathodes with High Performance.

The practical application of Na-ion cathode materials is currently restricted by their low energy density and sluggish dynamics, while the cation-disordered rocksalt (DRX) structures offer a possible solution to the challenge. In this study, among the 24 candidates containing elements, we use mixing temperature as a descriptor to screen the synthesizable Na-excess DRX, and we have identified NaMnMoO as the most promising candidate that exhibits a Na percolating fraction of 53%, which is higher than that of LiMnTiO (35%) proposed in the previous study due to the larger lattice constant in Na-excess DRX cathodes. More importantly, NaMnMoO is predicted to have a capacity of 228 mAh/g with an energy density of 552 Wh/kg derived from percolation theory and cluster-expansion Monte Carlo simulations, which is higher than that of NaNbMnO and NaMnTiO synthesized recently.