Vestibular function analysis of sudden sensorineural hearing loss with dizziness.

Background: A considerable number of patients with sudden sensorineural hearing loss (SSNHL) have been reported to have dizziness.

Objective: To analyze vestibular functions and identify the clinical characteristics of SSNHL with dizzinessMETHODS:71 patients with SSNHL who complained of dizziness were investigated retrospectively. The patients underwent vestibular function tests consisting of video-nystagmography, video head impulse test and vestibular evoked myogenic potentials.

Comparing the Suppression Head Impulse Paradigm and the Head Impulse Paradigm in Vestibular Neuritis.

Objective: To compare the results of suppression head impulse paradigm (SHIMP) and head impulse paradigm (HIMP) in acute vestibular neuritis (AVN).

Study Design: Retrospective study.

Setting: Tertiary otology clinic.

Does the Width of the Bony Cochlear Nerve Canal Predict the Outcomes of Cochlear Implantation?

A narrow bony cochlear nerve canal (BCNC) is associated with sensorineural hearing loss necessitating cochlear implantation (CI). This study evaluated the implications of BCNC width for post-CI outcomes. A total of 56 children who had received CIs were included.

Incus footplate assembly: Indication and surgical outcome.

Objectives/hypothesis: To review surgical findings and hearing outcomes of incus footplate assembly (IFA) for the patients with conductive hearing loss due to missing stapes superstructure with a mobile stapes footplate.

Study Design: Retrospective case review and survey.

Methods: Pre- and postoperative audiometric data and intraoperative findings were reviewed.

Cochlear Implantation in Patients With CHARGE Syndrome.

Objective: To determine the optimal surgical approach for cochlear implantation (CI) preoperatively based on the spatial relation of a displaced facial nerve (FN) and middle ear structures and to analyze clinical outcomes of CHARGE syndrome.

Methods: Facial nerve displacement and associated deviation of inner ear structures were analyzed in 13 patients (17 ears) with CHARGE syndrome who underwent CI. Surgical accessibility through the facial recess was assessed based on anatomical landmarks.

Optimal use of CT imaging in pediatric congenital cholesteatoma.

Objective: This study aimed to determine the radiation dose of temporal bone computed tomography (TBCT) to detect pediatric congenital cholesteatoma (CC), and suggests strategy for lowering perioperative radiation dose.

Methods: Fifty-three CC patients followed up for more than 12 months after surgery. Perioperative clinical findings and the effective radiation dose (ERD) of TBCT were investigated.

Diverse clinical and laboratory manifestations of bilateral vestibulopathy.

Objectives/hypothesis: To identify the clinical and laboratory characteristics of bilateral vestibulopathy (BVP) on the video head impulse test (vHIT).

Study Design: Retrospective chart analysis.

Methods: During 23 months, 1,789 patients with dizziness underwent vHIT in our tertiary referral hospital.

Long-term functional and behavioral-emotional outcomes in children with early cochlear implants: Parental testimonies.

Objectives: (1) To assess the long-term effects of cochlear implantation (CI) on speech perception and school life, and (2) to evaluate behavioral and emotional development, including social skills, post-implantation.

Methods: We telephoned caregivers and asked them a standardized questionnaire. We used the data to explore the daily lives (including school life) of children who had undergone CI before the age of 4 years and who had used the device for >10 years.

Corrigendum: Determinants of Conductive Hearing Loss in Tympanic Membrane Perforation: Correction of the Sixth Author Name.

[This corrects the article on p. 92 in vol. 8, PMID: 26045905.

Clinical observations and molecular variables of patients with hearing loss and incomplete partition type III.

Objectives/hypothesis: To analyze the clinical manifestations and genetic features of patients with hearing loss (HL) and incomplete partition (IP) type III malformation, and to evaluate speech performance after cochlear implantation (CI) in these patients.

Study Design: Individual retrospective cohort study.

Methods: Of 206 probands with inner ear malformations (IEMs), we constructed a homogeneous cohort of 11 genetically documented IP type III (DFNX2).

Factors Contributing to Speech Performance in Elderly Cochlear Implanted Patients: An FDG-PET Study: A Preliminary Study.

Objective: The purpose was to evaluate brain plasticity that contributes to speech performance after cochlear implantation (CI) in postlingual elderly (>60 years) patients.

Materials And Methods: Fifteen elderly postlingual deaf patients who underwent preoperative brain fluorodeoxyglucose positron emission tomography (FDG-PET) and were followed-up for more than 1 year after CI were included. The mean age of these patients was 64.

Facial nerve stimulation in the narrow bony cochlear nerve canal after cochlear implantation.

Objectives/hypothesis: To evaluate the correlation between a narrow bony cochlear nerve canal (BCNC) and facial nerve stimulation (FNS) after cochlear implantation (CI) and their underlying mechanisms and to predict the risk of FNS preoperatively.

Study Design: Retrospective cohort study.

Methods: A total of 64 pediatric cases that underwent CI were included.

Determinants of conductive hearing loss in tympanic membrane perforation.

Objectives: Tympanic membrane perforations are common, but there have been few studies of the factors determining the extent of the resulting conductive hearing loss. The aims of this study were to determine whether the size of tympanic membrane perforation, pneumatization of middle ear & mastoid cavity, and location of perforation were correlated with air-bone gap (ABG) of patients.

Methods: Forty-two patients who underwent tympanoplasty type I or myringoplasty were included and preoperative audiometry were analyzed.

Auditory brainstem responses to CE-Chirp® stimuli for normal ears and those with sensorineural hearing loss.

Objective: Evaluation of the characteristic differences between click-and CE-Chirp-evoked auditory brainstem responses (ABRs) in normal hearing and sensorineural hearing loss.

Design: A prospective study. Ears with normal hearing and with sensorineural hearing loss were evaluated.

Targeted Exome Sequencing of Deafness Genes After Failure of Auditory Phenotype-Driven Candidate Gene Screening.

Objective: To demonstrate the efficacy and advantages of targeted exome sequencing (TES) of known deafness genes in cases with failed or misleading auditory phenotype-driven candidate gene screening.

Study Design: Prospective cohort survey.

Setting: Otolaryngology department of a tertiary referral hospital.

Assessing the effects of tinnitus retraining therapy in patients lost to follow-up: a telephone survey.

Objective: To evaluate the efficacy of tinnitus retraining therapy (TRT), especially in patients who did not revisit the clinic after starting the program, and to determine the current status of patients who were lost to follow-up.

Study Design: Telephone survey.

Setting: Tertiary referral center.

Long-term outcome of cochlear implant in patients with chronic otitis media: one-stage surgery is equivalent to two-stage surgery.

This study compared long-term speech performance after cochlear implantation (CI) between surgical strategies in patients with chronic otitis media (COM). Thirty patients with available open-set sentence scores measured more than 2 yr postoperatively were included: 17 who received one-stage surgeries (One-stage group), and the other 13 underwent two-stage surgeries (Two-stage group). Preoperative inflammatory status, intraoperative procedures, postoperative outcomes were compared.

Effect of aided hearing in the nonimplanted ear on bimodal hearing.

Objective: This study was designed to evaluate the binaural effects from bimodal hearing according to the aided hearing threshold in the nonimplanted ear.

Materials And Methods: Subjects included 17 individuals who continued to use a hearing aid (HA) in the nonimplanted ear for more than 6 months postoperatively. Speech perception and sound localization were tested with unilateral cochlear implantation (CI) and bimodal hearing with and without background noise.

Malleostapedotomy revisited: the advantages of malleus neck-anchoring malleostapedotomy.

Objective: To extend our preliminary study by comparing the hearing outcomes of handle-malleostapedotomy (handle-MS; connecting the prosthesis to the malleus handle) and neck-MS (connecting the prosthesis to the malleus neck) in a larger case series.

Patients: Thirty-five patients who underwent MS at Seoul National University Hospital from January 1983 to December 2013.

Intervention: Review of pre- and postoperative audiometric data, intraoperative findings.

De novo large genomic deletions involving POU3F4 in incomplete partition type III inner ear anomaly in East Asian populations and implications for genetic counseling.

Objective: The aim of this study was to understand the prevalence and molecular genetic etiology of incomplete partition type III (IP type III) anomaly in Koreans. We also attempted to verify the prevalence of genomic deletions in the DFNX2 locus and to look for association between inheritance patterns and mutation type in East Asian IP type III subjects.

Study Design: Retrospective case review.

A novel mutation of TMPRSS3 related to milder auditory phenotype in Korean postlingual deafness: a possible future implication for a personalized auditory rehabilitation.

Unlabelled: Appropriate customized auditory rehabilitation for hearing impaired subjects requires prediction of residual hearing and progression of hearing loss. Mutations in TMPRSS3 encoding a transmembrane serine protease were reported to be associated with two different autosomal recessive nonsyndromic hearing loss (arNSHL) phenotypes, DFNB8 and DFNB10, in terms of residual hearing that may mandate different rehabilitation. We aimed to reveal the genetic contribution of TMPRSS3 mutations among Korean populations and to correlate the clinical phenotype with TMPRSS3 genotypes.

Effects of congruent and incongruent visual cues on speech perception and brain activity in cochlear implant users.

While deafness-induced plasticity has been investigated in the visual and auditory domains, not much is known about language processing in audiovisual multimodal environments for patients with restored hearing via cochlear implant (CI) devices. Here, we examined the effect of agreeing or conflicting visual inputs on auditory processing in deaf patients equipped with degraded artificial hearing. Ten post-lingually deafened CI users with good performance, along with matched control subjects, underwent H 2 (15) O-positron emission tomography scans while carrying out a behavioral task requiring the extraction of speech information from unimodal auditory stimuli, bimodal audiovisual congruent stimuli, and incongruent stimuli.

Prevalence of p.V37I variant of GJB2 in mild or moderate hearing loss in a pediatric population and the interpretation of its pathogenicity.

A p.V37I variant of GJB2 has been reported from subjects with moderate or slight hearing loss especially in East Asian populations. This study aimed to estimate the prevalence of the p.

Clinical characteristics of patients with narrow bony cochlear nerve canal: is the bilateral case just a duplicate of the unilateral case?

Objectives/hypothesis: To evaluate whether there is a genetic contribution to the development of narrow bony cochlear nerve canal and analyze the differences between unilateral and bilateral narrow bony cochlear nerve canal.

Study Design: Retrospective review.

Methods: Patients diagnosed with unilateral (n=44) or bilateral (n=13) sensorineural hearing loss with narrow bony cochlear nerve canals from October 2004 to July 2011 were evaluated.