Publications by authors named "Sun Mok Ha"
The Kir4.1 channel, an inwardly rectifying potassium ion (K) channel, is located in the hair cells of the organ of Corti as well as the intermediate cells of the stria vascularis. The Kir4.
View Article and Find Full Text PDFBackground: We previously showed that aging accelerates after 3 months of exposure to hypoxia and environmental change but not genetic modifications. Here, we aimed to simply induce early-onset age-related hearing loss within a short period based on our previous method.
Methods: We randomly divided 16 C57BL/6 mice into four groups that were maintained under conditions of normoxia and hypoxia with or without injected D-galactose for 2 months.
Background: Ototoxicity currently has no available treatment other than medication withdrawal as soon as toxicity is suspected. The human inner ear organs have little potential for regeneration; thus, ototoxicity-induced hair cell injury is deemed permanent. Dexamethasone (Dexa) is a synthetic steroid analog that has significant potential for otoprotection in the treatment of various inner ear diseases; however, its low absorption into the inner ear prevents significant recovery of function.
View Article and Find Full Text PDFAtmospheric particulate matter (PM) contains different components that can elicit varying adverse health effects in humans and animals. Studies on PM toxicity and its underlying mechanisms in the middle ear are limited, and they generally use a PM standard. However, as PM composition varies temporally and geographically, it is crucial to identify the toxic PM constituents according to season and region and investigate their associated health effects.
View Article and Find Full Text PDFArticle Synopsis
- Early detection of inner ear cell damage is crucial for preserving hearing, but current methods only identify problems after hearing loss has occurred.
- This study focuses on assessing circulating microRNA levels as a potential early indicator for idiopathic sudden sensorineural hearing loss (ISSNHL) by comparing 21 patients to 24 healthy individuals.
- Analysis showed that five specific circulating microRNAs had significantly different expression levels between the two groups, leading to a promising sensitivity of 80.95% and specificity of 87.50% for detecting ISSNHL.
Rationale: Epithelial-myoepithelial carcinoma is an extremely rare, malignant neoplasm that occurs most frequently in the major salivary glands and accounts for approximately 1% of all salivary gland neoplasms. Few reports have described the presence of epithelial-myoepithelial carcinoma in the sinonasal region; hence, the treatment guideline and prognosis remain unclear.
Patient Concerns: We reported a case of a 75-year-old woman with complaint of nasal obstruction and frequent epistaxis for 3 years.