Publications by authors named "Sun Mi Choi"
Article Synopsis
- - The study evaluated the safety and effectiveness of Fybro, a generic antifibrotic medication for idiopathic pulmonary fibrosis (IPF), with a focus on its real-world performance over 6-12 months.
- - Out of 359 patients enrolled, a large majority (71.9%) experienced adverse events, with decreased appetite being the most common issue; however, lung function decline rates did not vary significantly across different dosages of Fybro.
- - The findings suggest that using higher-dose Fybro tablets can enhance patient adherence to medication regimens, proposing that fewer pills daily may lead to better treatment compliance.
Article Synopsis
- Lymphangioleiomyomatosis (LAM) is a rare disorder marked by the growth of abnormal smooth muscle-like cells, and the effectiveness of serum VEGF-D as a diagnostic tool in Korean patients needs evaluation.
- This study collected serum samples from 40 LAM patients and 24 controls to measure VEGF-D levels and analyze its diagnostic potential using ROC curve analysis.
- Results indicated that serum VEGF-D levels were significantly elevated in LAM patients, showing strong predictive value for diagnosis, making it a potentially useful biomarker for this condition in the Korean population.
We have examined whether the copper reduction slag (CRS) generated after recovering valuable metals from copper slag (CS) by reduction process can be used as supplementary cementitious materials (SCMs). According to the test results, the Cu secondary slag with low Fe, Cu, and heavy metal contents had a suitable oxide composition for using as a SCM. CRS showed better grinding efficiency than that of ground blast furnace slag (GGBS).
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- The study highlights the high mortality rate of patients on the lung transplant waitlist in Korea, necessitating fair allocation policies due to a shortage of donors.
- Researchers simulated the Eurotransplant lung allocation score (ET-LAS) using data from the Korean Organ Transplantation Registry (KOTRY) to evaluate the current urgency-based system.
- Findings suggest that the existing allocation criteria may not effectively prioritize patients based on urgency, particularly for those not in the highest urgency status, indicating a need for policy revision.
The progression of idiopathic pulmonary fibrosis (IPF) is assessed through serial monitoring of forced vital capacity (FVC). Currently, data regarding the clinical significance of longitudinal changes in diffusing capacity for carbon monoxide (DLCO) is lacking. We investigated the prognostic implications of a 1-year decline in DLCO in 319 patients newly diagnosed with IPF at a tertiary hospital between January 2010 and December 2020.
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- * A study using South Korea's National Health Insurance database included 10,568 newly diagnosed IPF patients and revealed that statin use was linked to a significantly lower risk of developing IPF compared to a matched control group.
- * Additionally, statin use at diagnosis was associated with better survival rates in IPF patients, pointing to the need for more in-depth future studies to fully understand statin therapy's potential benefits in IPF treatment.
Purpose To investigate quantitative CT (QCT) measurement variability in interstitial lung disease (ILD) on the basis of two same-day CT scans. Materials and Methods Participants with ILD were enrolled in this multicenter prospective study between March and October 2022. Participants underwent two same-day CT scans at an interval of a few minutes.
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- A deep learning-based prognostic model (DLPM) was developed and validated to predict survival in patients with idiopathic pulmonary fibrosis (IPF) using chest radiographs from multiple datasets.
- The model demonstrated equal or superior performance compared to traditional forced vital capacity (FVC) measurements in predicting 3-year survival rates across different external test cohorts.
- The modified gender-age-physiology index (GAP-CR), which incorporates the DLPM, also outperformed the original GAP index in predicting survival in most test cohorts, highlighting the model's clinical relevance.
Article Synopsis
- - The study aimed to compare the effects of high-dose (pulse) corticosteroids versus standard-dose corticosteroids on survival in patients with acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF).
- - Researchers analyzed data from 238 patients treated with corticosteroids, finding that the pulse regimen did not significantly improve survival rates at both 3 and 12 months compared to the non-pulse regimen.
- - The conclusion emphasizes that there was no difference in survival outcomes between the two dosing strategies, highlighting the need for more comprehensive studies to determine the best initial corticosteroid dose for AE-IPF treatment.
This corrects the article on p. e294 in vol. 37, PMID: 36281485.
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- Recent reports indicate that pneumonitis may be a rare complication following SARS-CoV-2 vaccinations, with this study aiming to clarify its clinical features and outcomes.
- A nationwide survey identified 49 cases of vaccine-associated pneumonitis, with most patients being male and a median age of 66 years; symptoms typically manifested within 5 days post-vaccination.
- Although many patients saw improvement with corticosteroid treatment, 20% experienced worsening symptoms, and there was an observed mortality rate of 17%.
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease that has no cure. Although mesenchymal stem cells (MSCs) have been reported to ameliorate lung inflammation and fibrosis in mouse models, their mechanisms of action remain unknown. Therefore, we aimed to determine the changes in various immune cells, especially macrophages and monocytes, involved in the effects of MSC treatment on pulmonary fibrosis.
View Article and Find Full Text PDFBackground: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease (ILD) with variable and heterogeneous clinical course. The GAP (gender, age, and physiology) model had been used to predict mortality in patients with IPF, but does not contain exercise capacity. Therefore, our aim in this study was to develop new prognostic scoring system in the Korea IPF Cohort (KICO) registry.
View Article and Find Full Text PDFBackground: Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure, fatal infectious complications have been reported. However, adequate preventive strategies have not been determined. We aimed to investigate the effect of chlorhexidine mouthrinse on the prevention of microbial contamination during EBUS-TBNA.
View Article and Find Full Text PDFBackground: Antifibrotic therapy can slow disease progression (DP) in patients with idiopathic pulmonary fibrosis (IPF). However, the prognostic biomarkers for DP in patients with IPF receiving antifibrotic therapy have not been identified. Therefore, we aimed to evaluate the prognostic efficacy of serum Krebs von den Lungen-6 (KL-6) for DP in patients with IPF receiving antifibrotic therapy.
View Article and Find Full Text PDFBackground: Nutritional status is associated with mortality. The modified Nutrition Risk in the Critically Ill (mNUTRIC) score is one of the most commonly used nutritional risk assessment tools in intensive care units (ICUs). The purpose of this study was to compare the mortality predictive ability of the mNUTRIC score to that of the mNUTRIC-S2 score, which uses the Simplified Acute Physiology Score (SAPS) II instead of the Acute Physiology and Chronic Health Evaluation (APACHE) II.
View Article and Find Full Text PDFBackground: Delayed intubation is associated with poor prognosis in patients with respiratory failure. However, the effect of delayed intubation in patients with idiopathic pulmonary fibrosis (IPF) remains unknown. This study aimed to analyze whether timing of intubation after high-concentration oxygen therapy was associated with worse clinical outcomes in IPF patients.
View Article and Find Full Text PDFLong-term sequelae refer to persistent symptoms or signs for >6 months after SARS-CoV-2 infection. The most common symptoms of sequelae are fatigue and neuropsychiatric symptoms (concentration difficulty, amnesia, cognitive dysfunction, anxiety, and depression). However, approved treatments have not been fully established.
View Article and Find Full Text PDFBackground: The demand for lung transplants continues to increase in Korea, and donor shortages and waitlist mortality are critical issues. This study aimed to evaluate the factors that affect waitlist outcomes from the time of registration for lung transplantation in Korea.
Methods: Data were obtained from the Korean Network for Organ Sharing for lung-only registrations between September 7, 2009, and December 31, 2020.
Saam Acupuncture for Treating Functional Dyspepsia: A Feasibility Randomized Controlled Trial.
Evid Based Complement Alternat Med
June 2022
Objective: Functional dyspepsia (FD) is a common gastrointestinal disorder that significantly affects sufferers' quality of life and increases the economic burden on society. Saam acupuncture, a form of traditional Korean acupuncture, is frequently used to treat FD in Korean medicine clinical settings. This study aimed to evaluate the feasibility and preliminary effectiveness and safety of Saam acupuncture for treating FD.
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- * A new pipeline was developed that improves the analysis of mixed samples, exhibiting a low average error rate of 0.78% in combined reference reads, allowing for clearer results in clustering cell types.
- * The pipeline effectively identifies various cell types in cancer tissues and addresses challenges like misalignment, multi-mapping errors, and false positives from ambient RNA, making it a valuable tool for single-cell data analysis in research.
Article Synopsis
- Acute exacerbation significantly impacts the prognosis of patients with interstitial lung disease (ILD), prompting a study to identify the best prognostic biomarker among hospitalized patients.
- The study analyzed clinical data from 96 patients, revealing that factors like higher lactate dehydrogenase, elevated C-reactive protein, and a significant increase in Krebs von den Lungen-6 levels correlate with worse survival outcomes.
- The findings suggest that monitoring changes in KL-6 along with baseline CRP levels and P/F ratio can effectively predict in-hospital mortality for patients experiencing acute exacerbation of ILD.
Background: Lung transplantation (LT) is the gold standard for various end-stage chronic lung diseases and could be a salvage therapeutic option in acute respiratory distress syndrome (ARDS). However, LT is uncertain in patients with coronavirus disease 2019 (COVID-19)-related ARDS who failed to recover despite optimal management including extracorporeal membrane oxygenation (ECMO). This study aims to describe the pooled experience of LT for patients with severe COVID-19-related ARDS in Korea.
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