Plant Extracts as a Source of Natural Products with Potential Antimalarial Effects: An Update from 2018 to 2022.

Malaria kills more than 500,000 people yearly, mainly affecting Africa and Southeast Asia. The disease is caused by the protozoan parasite from the genus , with and being the main species that cause the disease in humans. Although substantial progress has been observed in malaria research in the last years, the threat of the spread of parasites persists.

Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against and .

Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very distinct microorganisms such as and , including pyruvate dehydrogenase (PDH) and -ketoglutarate dehydrogenase (KDH). In this mini review, we revisit the recent literature regarding LA metabolism in and , by covering the lipoate ligase proteins in both microorganisms, the role of lipoate ligase proteins and insights for possible inhibitors of lipoate ligases.

Live and Let Dye: Visualizing the Cellular Compartments of the Malaria Parasite Plasmodium falciparum.

Malaria remains one of the deadliest diseases worldwide and it is caused by the protozoan parasite Plasmodium spp. Parasite visualization is an important tool for the correct detection of malarial cases but also to understand its biology. Advances in visualization techniques promote new insights into the complex life cycle and biology of Plasmodium parasites.