Publications by authors named "Sun Kyung Yoon"
Article Synopsis
- This study assessed long-term immunity in adults who received the BA.4/5 bivalent COVID-19 vaccine, focusing on both antibody and T-cell responses.
- Participants showed significant increases in anti-binding domain IgG and neutralizing antibodies (NAb) against certain Omicron variants by 9 months post-vaccination.
- The T-cell responses were robust and cross-reactive for both previously infected and SARS-CoV-2-naïve individuals, although there was minimal increase after vaccination.
Article Synopsis
- - Researchers developed a new transient overexpression vector to quickly produce large amounts of antigen proteins needed for vaccine evaluation against infectious diseases, moving beyond just using the CMV promoter.
- - The constructed vector, which included a combination of transcriptional and translational enhancers, demonstrated significantly higher efficiency, yielding about 27 times more enhanced green fluorescent protein compared to a control vector.
- - The highest protein expression was achieved using the vector with the human elongation factor 1-alpha (EF-1a) promoter, likely due to the combined effects of the CMV enhancer improving transcription and the synergistic action of both promoters.
Article Synopsis
- * Methods: A clinical trial was conducted with 154 healthy adults who received either both vaccines at the same time or separately, with follow-ups for adverse events and immune response assessments over six months.
- * Results: While the combined vaccine group showed slightly lower overall antibody response rates for some coronavirus strains compared to the separate vaccine group, it produced a stronger neutralizing antibody response against the Omicron variant, with mostly mild side effects reported in both groups.
Article Synopsis
- Bivalent COVID-19 vaccines targeting Omicron subvariants BA.1 and BA.4/BA.5 were studied to evaluate their effectiveness in producing neutralizing antibodies (Nabs) after vaccination.
- The study involved 21 participants and found that those previously infected with BA.1/BA.2 or BA.5 had significantly higher levels of Nabs compared to non-infected individuals following the booster shot.
- Both bivalent vaccine formulations demonstrated similar immunogenicity, but even with the booster, the neutralizing activity against newer Omicron strains (BQ.1.1, BN.1, and XBB.1) was still deemed insufficient for adequate protection.
Article Synopsis
- The CoV2-001 phase I trial tested the GLS-5310 DNA vaccine for safety and immune response over 48 weeks with 45 participants who had not previously been vaccinated.* -
- Participants received two doses of the vaccine, administered intradermally at varying doses and intervals, and the vaccine was found to be well-tolerated with no serious side effects.* -
- The results showed high antibody and T cell responses, with 95.5% of participants producing anti-spike antibodies and 97.8% showing T cell responses, highlighting the vaccine's strong immunogenicity compared to other vaccines.*
Objective: Quantitative electroencephalography (qEEG) has been increasingly used to evaluate patients with attention deficit hyperactivity disorder (ADHD). The aim of this study was to assess the correlation between qEEG data and symptom severity in patients with ADHD.
Methods: Fifteen patients with ADHD and 20 healthy controls (HCs) were recruited.
Effects of propofol and etomidate on hydrogen peroxide-induced oxidative damage in hepatocyte.
Korean J Anesthesiol
September 2009
Background: The present investigation was undertaken to evaluate the protective effect of propofol and etomidate against hydrogen peroxide (H2O2) induced oxidative damage in human hepatic SNU761 cells by measuring lactate dehydrogenase (LDH).
Methods: The cell line of human hepatocellular carcinoma was grown for 24 hours in dissociated cell culture. They were divided into eight groups: negative control (NC) group with no drug administration, positive control (PC) group with H2O2 250 micrometer and other groups pretreated with propofol (P; 1, 10, 50 micrometer) or etomidate (ET; 1, 10, 50 micrometer) followed H2O2 administration.
Percutaneous device closure of atrial septal defect (ASD) has proven to be safe and effective, and become a widely accepted option to the surgical repair. However, the embolization of Amplatzer septal occluder (ASO) occurs in about 0.55% to 3.
View Article and Find Full Text PDFPrevalence of Campylobacter in raw chicken meat and human stools and subsequent antibiotic resistance profiles of the pathogenic isolates obtained from 2000 through 2002 were investigated. Campylobacter jejuni and Campylobacter coli were isolated from 570 of the 923 raw chicken meat samples collected from traditional markets, large retail stores, or department stores in Korea, resulting in the isolation rate of 61.8%.
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